Publications by authors named "Sylvain A Jacques"

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Novel library synthesis of 3,4-disubstituted pyridin-2(1)-ones via cleavage of pyridine-2-oxy-7-azabenzotriazole ethers under ionic hydrogenation conditions at room temperature.
Romain Pierre, Anne Brethon, Sylvain A Jacques, Aurélie Blond, Sandrine Chambon

Beilstein J Org Chem· January 2021

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Inhibition of the NAD salvage pathway in schistosomes impairs metabolism, reproduction, and parasite survival.
Michael D Schultz, Tulin Dadali, Sylvain A Jacques, Hélène Muller-Steffner, Jeremy B Foote

PLoS Pathog· May 2020

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Efficient Inhibition of SmNACE by Coordination Complexes Is Abolished by S. mansoni Sequestration of Metal.
Hélène Muller-Steffner, Sylvain A Jacques, Isabelle Kuhn, Michael D Schultz, Davide Botta

ACS Chem Biol· July 2017

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Corrigendum: MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.
Helge Gad, Tobias Koolmeister, Ann-Sofie Jemth, Saeed Eshtad, Sylvain A Jacques, Marie-Caroline Jacques-Cordonnier

Nature· April 2017

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Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities.
Kumar Sanjiv, Anna Hagenkort, José Manuel Calderón-Montaño, Tobias Koolmeister, Philip M Reaper, Sylvain A Jacques

Cell Rep· December 2016

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From solution to in-cell study of the chemical reactivity of acid sensitive functional groups: a rational approach towards improved cleavable linkers for biospecific endosomal release.
Sylvain A Jacques, Geoffray Leriche, Michel Mosser, Marc Nothisen, Christian D Muller

Org Biomol Chem· June 2016

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Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1.
Sabin Llona-Minguez, Andreas Höglund, Sylvain A Jacques, Lars Johansson, José Manuel Calderón-Montaño

J Med Chem· February 2016

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Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities.
Kumar Sanjiv, Anna Hagenkort, José Manuel Calderón-Montaño, Tobias Koolmeister, Philip M Reaper, Sylvain A Jacques

Cell Rep· January 2016

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Spiro Diorthoester (SpiDo), a Human Plasma Stable Acid-Sensitive Cleavable Linker for Lysosomal Release.
Geoffray Leriche, Marc Nothisen, Nadège Baumlin, Christian D Muller, Dominique Bagnard, Sylvain A Jacques

Bioconjug Chem· August 2015

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Vinylic MIDA Boronates: New Building Blocks for the Synthesis of Aza-Heterocycles.
Sabin Llona-Minguez, Matthieu Desroses, Artin Ghassemian, Sylvain A Jacques, Lars Eriksson

Chemistry· May 2015

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Discovery of Potent Inhibitors of Schistosoma mansoni NAD⁺ Catabolizing Enzyme.
Sylvain A Jacques, Isabelle Kuhn, Oleksandr Koniev, Francis Schuber, Frances E Lund

J Med Chem· April 2015

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Chemical strategies for development of ATR inhibitors.
Sabin Llona-Minguez, Andreas Höglund, Sylvain A Jacques, Tobias Koolmeister, Thomas Helleday

Expert Rev Mol Med· May 2014

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MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.
Helge Gad, Tobias Koolmeister, Ann-Sofie Jemth, Saeed Eshtad, Sylvain A Jacques, Marie-Caroline Jacques-Cordonnier

Nature· April 2014

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