Publications by authors named "Taiji Asami"

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Discovery of novel indole derivatives as potent and selective inhibitors of proMMP-9 activation.
Rie Nishikawa-Shimono, Motoi Kuwabara, Sho Fujisaki, Daisuke Matsuda, Mayumi Endo, Taiji Asami

Bioorg Med Chem Lett· January 2024

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Discovery of TP0628103: A Highly Potent and Selective MMP-7 Inhibitor with Reduced OATP-Mediated Clearance Designed by Shifting Isoelectric Points.
Yusuke Oka, Kumi Abe-Sato, Hideaki Tabuse, Yoshifumi Yasukawa, Tohru Yahara, Taiji Asami

J Med Chem· January 2024

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Quantitation of Cell Membrane Permeability of Cyclic Peptides by Single-Cell Cytoplasm Mass Spectrometry.
Takayuki Kawai, Yasuhiro Mihara, Makiko Morita, Masahiko Ohkubo, Taiji Asami

Anal Chem· February 2021

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A new class of pentapeptide KISS1 receptor agonists with hypothalamic-pituitary-gonadal axis activation.
Naoki Nishizawa, Taiji Asami, Kimiko Nishibori, Yoshihiro Takatsu, Atsuko Suzuki, Masami Kusaka

Bioorg Med Chem Lett· February 2019

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Antiobesity and emetic effects of a short-length peptide YY analog and its PEGylated and alkylated derivatives.
Ayumu Niida, Yoko Kanematsu-Yamaki, Tomoko Asakawa, Yoshimasa Ishimura, Hisashi Fujita, Taiji Asami

Bioorg Med Chem· February 2018

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Differential effects of selective agonists of neuromedin U1 and U2 receptors in obese and diabetic mice.
Hiroaki Nagai, Tomoko Kaisho, Kotaro Yokoyama, Tomoko Asakawa, Hisashi Fujita, Taiji Asami

Br J Pharmacol· January 2018

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A novel LRP1-binding peptide L57 that crosses the blood brain barrier.
Kotaro Sakamoto, Tokuyuki Shinohara, Yusuke Adachi, Taiji Asami, Tetsuya Ohtaki

Biochem Biophys Rep· December 2017

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Highly potent antiobesity effect of a short-length peptide YY analog in mice.
Naoki Nishizawa, Ayumu Niida, Yusuke Adachi, Yoko Kanematsu-Yamaki, Yasushi Masuda, Taiji Asami

Bioorg Med Chem· October 2017

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A potent neuromedin U receptor 2-selective alkylated peptide.
Naoki Nishizawa, Yoko Kanematsu-Yamaki, Masaaki Funata, Hiroaki Nagai, Ayako Shimizu, Taiji Asami

Bioorg Med Chem Lett· October 2017

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Identification of ligand-selective peptidic ActRIIB-antagonists using phage display technology.
Kotaro Sakamoto, Yoko Kanematsu-Yamaki, Yusuke Kamada, Masahiro Oka, Toshiyuki Ohnishi, Taiji Asami

Biochem Biophys Rep· September 2017

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A potent and selective natriuretic peptide receptor-3 blocker 11-mer peptide created by hybridization of musclin and atrial natriuretic peptide.
Naoki Nishizawa, Goshi Nakamura, Yoko Noguchi, Hideyuki Nakagawa, Ayako Shimizu, Taiji Asami

Bioorg Med Chem Lett· August 2017

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Potent antiobesity effect of a short-length peptide YY-analogue continuously administered in mice.
Naoki Nishizawa, Ayumu Niida, Yusuke Adachi, Yasushi Masuda, Satoshi Kumano, Taiji Asami

Bioorg Med Chem Lett· August 2017

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Potent Body Weight-Lowering Effect of a Neuromedin U Receptor 2-selective PEGylated Peptide.
Yoko Kanematsu-Yamaki, Naoki Nishizawa, Tomoko Kaisho, Hiroaki Nagai, Taisuke Mochida, Taiji Asami

J Med Chem· July 2017

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Potent and selective oxytocin receptor agonists without disulfide bridges.
Yusuke Adachi, Katsuya Sakimura, Yuji Shimizu, Masaharu Nakayama, Yasuko Terao, Taiji Asami

Bioorg Med Chem Lett· June 2017

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Investigation of the structural requirements of K-Ras(G12D) selective inhibitory peptide KRpep-2d using alanine scans and cysteine bridging.
Ayumu Niida, Shigekazu Sasaki, Kazuko Yonemori, Tomoya Sameshima, Masahiro Yaguchi, Taiji Asami

Bioorg Med Chem Lett· June 2017

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Antiobesity Effect of a Short-Length Peptide YY Analogue after Continuous Administration in Mice.
Naoki Nishizawa, Ayumu Niida, Yasushi Masuda, Satoshi Kumano, Kotaro Yokoyama, Taiji Asami

ACS Med Chem Lett· June 2017

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A Short-Length Peptide YY Analogue with Anorectic Effect in Mice.
Naoki Nishizawa, Ayumu Niida, Yasushi Masuda, Satoshi Kumano, Kotaro Yokoyama, Taiji Asami

ACS Omega· May 2017

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Investigation on cellular uptake and pharmacodynamics of DOCK2-inhibitory peptides conjugated with cell-penetrating peptides.
Yusuke Adachi, Kotaro Sakamoto, Tadashi Umemoto, Yasunori Fukuda, Akiyoshi Tani, Taiji Asami

Bioorg Med Chem· April 2017

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A PEGylated analog of short-length Neuromedin U with potent anorectic and anti-obesity effects.
Hiroshi Inooka, Kotaro Sakamoto, Tokuyuki Shinohara, Yasushi Masuda, Michiko Terada, Taiji Asami

Bioorg Med Chem· April 2017

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Novel DOCK2-selective inhibitory peptide that suppresses B-cell line migration.
Kotaro Sakamoto, Yusuke Adachi, Yusaku Komoike, Yusuke Kamada, Ryokichi Koyama, Taiji Asami

Biochem Biophys Res Commun· January 2017

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Generation of a novel artificial TrkB agonist, BM17d99, using T7 phage-displayed random peptide libraries.
Toshiyuki Ohnishi, Kotaro Sakamoto, Asano Asami-Odaka, Kimie Nakamura, Ayako Shimizu, Taiji Asami

Biochem Biophys Res Commun· January 2017

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Discovery of an artificial peptide agonist to the fibroblast growth factor receptor 1c/βKlotho complex from random peptide T7 phage display.
Kotaro Sakamoto, Yayoi Kawata, Yasushi Masuda, Tadashi Umemoto, Takashi Ito, Taiji Asami

Biochem Biophys Res Commun· November 2016

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Design and Synthesis of an Investigational Nonapeptide KISS1 Receptor (KISS1R) Agonist, Ac-d-Tyr-Hydroxyproline (Hyp)-Asn-Thr-Phe-azaGly-Leu-Arg(Me)-Trp-NH (TAK-448), with Highly Potent Testosterone-Suppressive Activity and Excellent Water Solubility.
Naoki Nishizawa, Yoshihiro Takatsu, Satoshi Kumano, Atsushi Kiba, Junko Ban, Masami Kusaka, Taiji Asami

J Med Chem· October 2016

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Effects and therapeutic potentials of kisspeptin analogs: regulation of the hypothalamic-pituitary-gonadal axis.
Hisanori Matsui, Taiji Asami

Neuroendocrinology· February 2015

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Physicochemically and pharmacokinetically stable nonapeptide KISS1 receptor agonists with highly potent testosterone-suppressive activity.
Taiji Asami, Naoki Nishizawa, Hisanori Matsui, Yoshihiro Takatsu, Atsuko Suzuki, Masami Kusaka

J Med Chem· July 2014

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