Publications by authors named "Takao Hashiguchi"

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SARS-CoV-2 inhibition through mRNA delivery using engineered extracellular vesicles displaying the spike protein.
Yuna Nakagawa, Yoshimasa Kawaguchi, Hisaaki Hirose, Takao Hashiguchi, Joseph Lee

Biomaterials· February 2026

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An open source for multiplexed, stable and transient flows to advance life sciences using microfluidic control automation.
Junichi Murai, Mahmoud N Abdelmoez, Keisuke Kondo, Kohei Takamuro, Keiji Nozaki, Takao Hashiguchi

Lab Chip· October 2025

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A Short Peptide Inhibitor of Measles Virus Fusion Protein that Exhibits Passive Membrane Permeability.
Ziwei Gao, Jiei Sasaki, Tateki Suzuki, Shinsuke Sando, Takao Hashiguchi

ChemMedChem· September 2025

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OTUD3 prevents ulcerative colitis by inhibiting microbiota-mediated STING activation.
Bo Li, Taiki Sakaguchi, Haruka Tani, Takayoshi Ito, Mari Murakami, Takao Hashiguchi

Sci Immunol· July 2025

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Determinants of susceptibility to SARS-CoV-2 infection in murine ACE2.
Takashi Kondo, Rigel Suzuki, Hisano Yajima, Sachiho Kawahara, Kodai Yamaya, Takao Hashiguchi

J Virol· June 2025

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Discovery of potent measles virus fusion inhibitor peptides structure-guided derivatization.
Ziwei Gao, Jiei Sasaki, Tateki Suzuki, Tomoaki Suzuki, Yuki Miwa, Takao Hashiguchi

RSC Med Chem· April 2025

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Structural and virological identification of neutralizing antibody footprint provides insights into therapeutic antibody design against SARS-CoV-2 variants.
Yuki Anraku, Shunsuke Kita, Taishi Onodera, Akihiko Sato, Takashi Tadokoro, Takao Hashiguchi

Commun Biol· March 2025

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Induction of IGHV3-53 public antibodies with broadly neutralising activity against SARS-CoV-2 including Omicron subvariants in a Delta breakthrough infection case.
Takeo Kuwata, Yu Kaku, Shashwata Biswas, Kaho Matsumoto, Mikiko Shimizu, Takao Hashiguchi

EBioMedicine· December 2024

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X-206 exhibits broad-spectrum anti-β-coronavirus activity, covering SARS-CoV-2 variants and drug-resistant isolates.
Jiei Sasaki, Akihiko Sato, Michihito Sasaki, Iori Okabe, Kota Kodama, Takao Hashiguchi

Antiviral Res· December 2024

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Molecular and structural insights into SARS-CoV-2 evolution: from BA.2 to XBB subvariants.
Hisano Yajima, Tomo Nomai, Kaho Okumura, Katsumi Maenaka, , Takao Hashiguchi

mBio· October 2024

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Structural basis for receptor-binding domain mobility of the spike in SARS-CoV-2 BA.2.86 and JN.1.
Hisano Yajima, Yuki Anraku, Yu Kaku, Kanako Terakado Kimura, Arnon Plianchaisuk, Takao Hashiguchi

Nat Commun· October 2024

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Virological characteristics of the SARS-CoV-2 Omicron EG.5.1 variant.
Shuhei Tsujino, Sayaka Deguchi, Tomo Nomai, Miguel Padilla-Blanco, Arnon Plianchaisuk, Takao Hashiguchi

Microbiol Immunol· September 2024

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Glycan-shielded homodimer structure and dynamical features of the canine distemper virus hemagglutinin relevant for viral entry and efficient vaccination.
Hideo Fukuhara, Kohei Yumoto, Miyuki Sako, Mizuho Kajikawa, Toyoyuki Ose, Takao Hashiguchi

Elife· July 2024

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Rational in silico design identifies two mutations that restore UT28K SARS-CoV-2 monoclonal antibody activity against Omicron BA.1.
Tatsuhiko Ozawa, Yoshiki Ikeda, Liuan Chen, Rigel Suzuki, Atsushi Hoshino, Takao Hashiguchi

Structure· March 2024

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Unveiling the affinity-stability relationship in anti-measles virus antibodies: a computational approach for hotspots prediction.
Rimpa Paul, Keisuke Kasahara, Jiei Sasaki, Jorge Fernández Pérez, Ryo Matsunaga, Takao Hashiguchi

Front Mol Biosci· March 2024

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Virological characteristics of the SARS-CoV-2 Omicron XBB.1.5 variant.
Tomokazu Tamura, Takashi Irie, Sayaka Deguchi, Hisano Yajima, Masumi Tsuda, Takao Hashiguchi

Nat Commun· February 2024

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Author Correction: Immune response and protective efficacy of the SARS-CoV-2 recombinant spike protein vaccine S-268019-b in mice.
Tomoyuki Homma, Noriyo Nagata, Masayuki Hashimoto, Naoko Iwata-Yoshikawa, Naomi M Seki, Takao Hashiguchi

Sci Rep· January 2024

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Heterogeneity and mitochondrial vulnerability configurate the divergent immunoreactivity of human induced microglia-like cells.
Kousuke Yonemoto, Fumihiko Fujii, Ryoji Taira, Masahiro Ohgidani, Katsuhide Eguchi, Takao Hashiguchi

Clin Immunol· October 2023

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Multiple mutations of SARS-CoV-2 Omicron BA.2 variant orchestrate its virological characteristics.
Izumi Kimura, Daichi Yamasoba, Hesham Nasser, Hayato Ito, Jiri Zahradnik, Takao Hashiguchi

J Virol· October 2023

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Structural basis for cross-group recognition of an influenza virus hemagglutinin antibody that targets postfusion stabilized epitope.
Keisuke Tonouchi, Yu Adachi, Tateki Suzuki, Daisuke Kuroda, Ayae Nishiyama, Takao Hashiguchi

PLoS Pathog· August 2023

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Structural delineation and computational design of SARS-CoV-2-neutralizing antibodies against Omicron subvariants.
Saya Moriyama, Yuki Anraku, Shunta Taminishi, Yu Adachi, Daisuke Kuroda, Takao Hashiguchi

Nat Commun· July 2023

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Metagenomics-enabled reverse-genetics assembly and characterization of myotis bat morbillivirus.
Satoshi Ikegame, Jillian C Carmichael, Heather Wells, Robert L Furler O'Brien, Joshua A Acklin, Takao Hashiguchi

Nat Microbiol· June 2023

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Interaction of the Hemagglutinin Stalk Region with Cell Adhesion Molecule (CADM) 1 and CADM2 Mediates the Spread between Neurons and Neuropathogenicity of Measles Virus with a Hyperfusogenic Fusion Protein.
Ryuichi Takemoto, Yuichi Hirai, Shumpei Watanabe, Hidetaka Harada, Tateki Suzuki, Takao Hashiguchi

J Virol· May 2023

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Convergent evolution of SARS-CoV-2 Omicron subvariants leading to the emergence of BQ.1.1 variant.
Jumpei Ito, Rigel Suzuki, Keiya Uriu, Yukari Itakura, Jiri Zahradnik, Takao Hashiguchi

Nat Commun· May 2023

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Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants.
Tomokazu Tamura, Jumpei Ito, Keiya Uriu, Jiri Zahradnik, Izumi Kida, Takao Hashiguchi

Nat Commun· May 2023

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