Publications by authors named "Takeo Funakoshi"

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5-HT receptor stimulation in the medial prefrontal cortex mediates the antidepressant effects of mGlu2/3 receptor antagonist in mice.
Kenichi Fukumoto, Michihiko Iijima, Takeo Funakoshi, Shigeyuki Chaki

Neuropharmacology· July 2018

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Role of 5-HT1A Receptor Stimulation in the Medial Prefrontal Cortex in the Sustained Antidepressant Effects of Ketamine.
Kenichi Fukumoto, Michihiko Iijima, Takeo Funakoshi, Shigeyuki Chaki

Int J Neuropsychopharmacol· April 2018

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Antidepressant/anxiolytic potential and adverse effect liabilities of melanin-concentrating hormone receptor 1 antagonists in animal models.
Shigeyuki Chaki, Toshiharu Shimazaki, Mariko Nishiguchi, Takeo Funakoshi, Michihiko Iijima

Pharmacol Biochem Behav· August 2015

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Dopamine receptor agonists reverse behavioral abnormalities of alpha-synuclein transgenic mouse, a new model of Parkinson's disease.
Masaki Wakamatsu, Shingo Iwata, Takeo Funakoshi, Makoto Yoshimoto

J Neurosci Res· February 2008

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Identification of 4-amino-2-cyclohexylaminoquinazolines as metabolically stable melanin-concentrating hormone receptor 1 antagonists.
Kosuke Kanuma, Katsunori Omodera, Mariko Nishiguchi, Takeo Funakoshi, Shigeyuki Chaki

Bioorg Med Chem· May 2006

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MCL0042: a nonpeptidic MC4 receptor antagonist and serotonin reuptake inhibitor with anxiolytic- and antidepressant-like activity.
Shigeyuki Chaki, Yuichi Oshida, Shin-Ichi Ogawa, Takeo Funakoshi, Toshiharu Shimazaki

Pharmacol Biochem Behav· December 2005

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Lead optimization of 4-(dimethylamino)quinazolines, potent and selective antagonists for the melanin-concentrating hormone receptor 1.
Kosuke Kanuma, Katsunori Omodera, Mariko Nishiguchi, Takeo Funakoshi, Shigeyuki Chaki

Bioorg Med Chem Lett· September 2005

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Anxiolytic- and antidepressant-like profile of ATC0065 and ATC0175: nonpeptidic and orally active melanin-concentrating hormone receptor 1 antagonists.
Shigeyuki Chaki, Takeo Funakoshi, Shiho Hirota-Okuno, Mariko Nishiguchi, Toshiharu Shimazaki

J Pharmacol Exp Ther· May 2005

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Discovery of 4-(dimethylamino)quinazolines as potent and selective antagonists for the melanin-concentrating hormone receptor 1.
Kosuke Kanuma, Katsunori Omodera, Mariko Nishiguchi, Takeo Funakoshi, Shigeyuki Chaki

Bioorg Med Chem Lett· May 2005

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Involvement of the melanocortin MC4 receptor in stress-related behavior in rodents.
Shigeyuki Chaki, Shin-ichi Ogawa, Yoshihisa Toda, Takeo Funakoshi, Shigeru Okuyama

Eur J Pharmacol· August 2003

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Anxiolytic-like and antidepressant-like activities of MCL0129 (1-[(S)-2-(4-fluorophenyl)-2-(4-isopropylpiperadin-1-yl)ethyl]-4-[4-(2-methoxynaphthalen-1-yl)butyl]piperazine), a novel and potent nonpeptide antagonist of the melanocortin-4 receptor.
Shigeyuki Chaki, Shiho Hirota, Takeo Funakoshi, Yoshiko Suzuki, Sayoko Suetake

J Pharmacol Exp Ther· February 2003

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In vitro and in vivo pharmacological profile of 4-(4-fluorobenzylidene)-1-[2-[5-(4-fluorophenyl)-1H-pyrazol-4-yl] ethyl] piperidine (NRA0161).
Yoshiko Suzuki, Takeo Funakoshi, Shigeyuki Chaki, Naoya Kawashima, Shin Ogawa

Life Sci· October 2002

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In vitro and in vivo pharmacological profile of 5-[2-[4-(6-fluoro-1H-indole-3-yl)piperidin-1-yl]ethyl]-4-(4-fluorophenyl)thiazole-2-carboxylic acid amide (NRA0562), a novel and putative atypical antipsychotic.
Takeo Funakoshi, Shigeyuki Chaki, Naoya Kawashima, Yoshiko Suzuki, Ryoko Yoshikawa

Life Sci· August 2002

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Antipsychotic profile of 5-[2-[4-(6-fluoro-1H-indole-3-yl)piperidin-1-yl]ethyl]-4-(4-fluorophenyl)thiazole-2-carboxylic acid amide (NRA0562) in rats.
Kazuaki Takamori, Takeo Funakoshi, Shiho Hirota, Shigeyuki Chaki, Kazuya Kameo

Life Sci· July 2002

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