Publications by authors named "Takuma Iguchi"

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Evaluation of interspecies differences in DS-2087b-induced gastrointestinal toxicity using mouse and monkey intestinal organoids.
Yuji Shirai, Takuma Iguchi, Kazunori Fujimoto, Masako Imaoka, Yuko Hasegawa

Toxicol Lett· December 2025

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Opportunities for microphysiological systems from the view of Japanese industries.
Hitoshi Naraoka, Takuma Iguchi, Kosuke Harada, Toru Usui, Yoshiaki Suwa

Drug Metab Pharmacokinet· February 2025

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Protein overexpression by adeno-associated virus-based gene therapy products in cardiomyocytes induces endoplasmic reticulum stress and myocardial degeneration in mice.
Kyohei Yasuno, Ryo Watanabe, Rumiko Ishida, Keiko Okado, Hirofumi Kondo, Takuma Iguchi

J Toxicol Pathol· October 2024

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En masse organoid phenotyping informs metabolic-associated genetic susceptibility to NASH.
Masaki Kimura, Takuma Iguchi, Kentaro Iwasawa, Andrew Dunn, Wendy L Thompson

Cell· October 2022

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Identification and Therapeutic Targeting of GPR20, Selectively Expressed in Gastrointestinal Stromal Tumors, with DS-6157a, a First-in-Class Antibody-Drug Conjugate.
Kenji Iida, Amr H Abdelhamid Ahmed, Akiko Kawano Nagatsuma, Tomoko Shibutani, Satoru Yasuda, Takuma Iguchi

Cancer Discov· June 2021

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Comprehensive analysis of cardiac function, blood biomarkers and histopathology for milrinone-induced cardiotoxicity in cynomolgus monkeys.
Katsuyoshi Chiba, Tomomichi Ishizaka, Yu Yoshimatsu, Kei Mikamoto, Yu Maeda, Takuma Iguchi

J Pharmacol Toxicol Methods· February 2021

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Outer retinal involvement in N-methyl-D-aspartate-induced inner retinal injury in rabbits assessed by optical coherence tomography.
Junzo Kinoshita, Katsumi Fujita, Kyohei Yasuno, Takami Suzuki, Takuma Iguchi

J Toxicol Sci· September 2020

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Identification of the dog orthologue of human MAS-related G protein coupled receptor X2 (MRGPRX2) essential for drug-induced pseudo-allergic reactions.
Eri Hamamura-Yasuno, Takuma Iguchi, Kazuyoshi Kumagai, Yoshimi Tsuchiya, Kazuhiko Mori

Sci Rep· September 2020

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Fluoroquinolones suppress gluconeogenesis by inhibiting fructose 1,6-bisphosphatase in primary monkey hepatocytes.
Takuma Iguchi, Koichi Goto, Kyoko Watanabe, Kazuyuki Hashimoto, Takami Suzuki

Toxicol In Vitro· June 2020

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A Novel HER3-Targeting Antibody-Drug Conjugate, U3-1402, Exhibits Potent Therapeutic Efficacy through the Delivery of Cytotoxic Payload by Efficient Internalization.
Yuuri Hashimoto, Kumiko Koyama, Yasuki Kamai, Kenji Hirotani, Yusuke Ogitani, Takuma Iguchi

Clin Cancer Res· December 2019

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Establishment of an in vitro cytotoxicity assay platform using primary monkey cardiomyocytes.
Takuma Iguchi, Kazunori Fujimoto, Shinichiro Nakamura, Hiroyuki Kishino, Noriyo Niino

Toxicol In Vitro· February 2019

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Plasma citrulline is a sensitive safety biomarker for small intestinal injury in rats.
Wataru Saitoh, Sanae Takada, Jun Hirao, Makoto Shirai, Takuma Iguchi

Toxicol Lett· October 2018

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Gene expression analysis of Arc mRNA as a neuronal cell activity marker in the hippocampus and amygdala in two-way active avoidance test in rats.
Kyohei Yasuno, Erika Takahashi, Isao Igarashi, Takuma Iguchi, Yoshimi Tsuchiya

J Pharmacol Toxicol Methods· July 2018

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DS-7250, a Diacylglycerol Acyltransferase 1 Inhibitor, Enhances Hepatic Steatosis in Zucker Fatty Rats via Upregulation of Fatty Acid Synthesis.
Kyohei Yasuno, Kazuyoshi Kumagai, Takuma Iguchi, Yoshimi Tsuchiya, Kiyonori Kai

Toxicol Pathol· April 2018

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Comprehensive Analysis of Circulating microRNA Specific to the Liver, Heart, and Skeletal Muscle of Cynomolgus Monkeys.
Takuma Iguchi, Noriyo Niino, Satoshi Tamai, Ken Sakurai, Kazuhiko Mori

Int J Toxicol· March 2018

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UNC569-induced Morphological Changes in Pigment Epithelia and Photoreceptor Cells in the Retina through MerTK Inhibition in Mice.
Ayako Sayama, Keiko Okado, Koichi Nakamura, Tatsuya Kawaguchi, Takuma Iguchi

Toxicol Pathol· February 2018

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Absolute Quantification of Plasma MicroRNA Levels in Cynomolgus Monkeys, Using Quantitative Real-time Reverse Transcription PCR.
Takuma Iguchi, Noriyo Niino, Satoshi Tamai, Ken Sakurai, Kazuhiko Mori

J Vis Exp· February 2018

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Circulating liver-specific microRNAs in cynomolgus monkeys.
Takuma Iguchi, Ken Sakurai, Satoshi Tamai, Kazuhiko Mori

J Toxicol Pathol· January 2018

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A monkey model of acetaminophen-induced hepatotoxicity; phenotypic similarity to human.
Satoshi Tamai, Takuma Iguchi, Noriyo Niino, Kei Mikamoto, Ken Sakurai

J Toxicol Sci· May 2017

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MicroRNA profiles in a monkey testicular injury model induced by testicular hyperthermia.
Ken Sakurai, Kei Mikamoto, Makoto Shirai, Takuma Iguchi, Kazumi Ito

J Appl Toxicol· December 2016

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Wide application of a novel topoisomerase I inhibitor-based drug conjugation technology.
Yusuke Ogitani, Yuki Abe, Takuma Iguchi, Junko Yamaguchi, Tomoko Terauchi

Bioorg Med Chem Lett· October 2016

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Hedgehog signaling through GLI1 and GLI2 is required for epithelial-mesenchymal transition in human trophoblasts.
Chao Tang, Liu Mei, Liyu Pan, Wenyi Xiong, Haibin Zhu, Takuma Iguchi

Biochim Biophys Acta· July 2015

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MicroRNA profiling in ethylene glycol monomethyl ether-induced monkey testicular toxicity model.
Ken Sakurai, Kei Mikamoto, Makoto Shirai, Takuma Iguchi, Kazumi Ito

J Toxicol Sci· June 2015

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Hedgehog signaling stimulates the conversion of cholesterol to steroids.
Chao Tang, Yibin Pan, Huan Luo, Wenyi Xiong, Haibin Zhu, Takuma Iguchi

Cell Signal· March 2015

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Ascorbic acid uptaken by sodium-dependent vitamin C transporter 2 induces βhCG expression through Sp1 and TFAP2A transcription factors in human choriocarcinoma cells.
Lihua Chen, Haibin Zhu, Yibin Pan, Chao Tang, Mai Watanabe, Takuma Iguchi

J Clin Endocrinol Metab· September 2012

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