Publications by authors named "Takuma Irie"

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KRAS mutations disrupt interactions between CD8+ T cells and antigen-presenting cells in the tumor microenvironment of biliary tract cancer.
Fumihiro Terasaki, Shogo Kumagai, Akito Fukuda, Yosuke Tanaka, Takuma Irie

Int Immunol· November 2025

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Microbiota-driven antitumour immunity mediated by dendritic cell migration.
Nina Yi-Tzu Lin, Shota Fukuoka, Shohei Koyama, Daisuke Motooka, Dieter M Tourlousse, Takuma Irie

Nature· August 2025

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A phase Ib study of photoimmunotherapy with ASP-1929 in combination with nivolumab for advanced gastric cancer (GE-PIT, EPOC1901).
Tomohiro Kadota, Rika Fujii, Shohei Koyama, Daisuke Kotani, Yusuke Yoda, Takuma Irie

Gastric Cancer· July 2025

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Atezolizumab following definitive chemoradiotherapy in patients with unresectable locally advanced esophageal squamous cell carcinoma - a multicenter phase 2 trial (EPOC1802).
Hideaki Bando, Shogo Kumagai, Daisuke Kotani, Saori Mishima, Takuma Irie

Nat Cancer· March 2025

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Coactivation of innate immune suppressive cells induces acquired resistance against combined TLR agonism and PD-1 blockade.
Hitomi Nishinakamura, Sayoko Shinya, Takuma Irie, Shugo Sakihama, Takeo Naito

Sci Transl Med· February 2025

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BATF epigenetically and transcriptionally controls the activation program of regulatory T cells in human tumors.
Kota Itahashi, Takuma Irie, Junichiro Yuda, Shogo Kumagai, Tokiyoshi Tanegashima

Sci Immunol· October 2022

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Regulatory T-cell development in the tumor microenvironment.
Kota Itahashi, Takuma Irie, Hiroyoshi Nishikawa

Eur J Immunol· August 2022

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Bronchoalveolar lavage fluid reveals factors contributing to the efficacy of PD-1 blockade in lung cancer.
Kentaro Masuhiro, Motohiro Tamiya, Kosuke Fujimoto, Shohei Koyama, Yujiro Naito, Takuma Irie

JCI Insight· May 2022

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Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments.
Shogo Kumagai, Shohei Koyama, Kota Itahashi, Tokiyoshi Tanegashima, Yi-Tzu Lin, Takuma Irie

Cancer Cell· February 2022

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PD-1 blockade therapy promotes infiltration of tumor-attacking exhausted T cell clonotypes.
Joji Nagasaki, Takashi Inozume, Nicolas Sax, Ryo Ariyasu, Masakazu Ishikawa, Takuma Irie

Cell Rep· February 2022

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Depletion of central memory CD8 T cells might impede the antitumor therapeutic effect of Mogamulizumab.
Yuka Maeda, Hisashi Wada, Daisuke Sugiyama, Takuro Saito, Takuma Irie

Nat Commun· December 2021

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Highly immunogenic cancer cells require activation of the WNT pathway for immunological escape.
Yoshiko Takeuchi, Tokiyoshi Tanegashima, Eiichi Sato, Takuma Irie, Atsuo Sai

Sci Immunol· November 2021

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Importance of lymph node immune responses in MSI-H/dMMR colorectal cancer.
Koji Inamori, Yosuke Togashi, Shota Fukuoka, Kiwamu Akagi, Kouetsu Ogasawara, Takuma Irie

JCI Insight· May 2021

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Potentiality of multiple modalities for single-cell analyses to evaluate the tumor microenvironment in clinical specimens.
Yukie Kashima, Yosuke Togashi, Shota Fukuoka, Takahiro Kamada, Takuma Irie

Sci Rep· January 2021

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The PD-1 expression balance between effector and regulatory T cells predicts the clinical efficacy of PD-1 blockade therapies.
Shogo Kumagai, Yosuke Togashi, Takahiro Kamada, Eri Sugiyama, Hitomi Nishinakamura, Takuma Irie

Nat Immunol· November 2020

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Immune Suppression by PD-L2 against Spontaneous and Treatment-Related Antitumor Immunity.
Tokiyoshi Tanegashima, Yosuke Togashi, Koichi Azuma, Akihiko Kawahara, Ko Ideguchi, Takuma Irie

Clin Cancer Res· August 2019

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A new computational method to predict transcriptional activity of a DNA sequence from diverse datasets of massively parallel reporter assays.
Ying Liu, Takuma Irie, Tetsushi Yada, Yutaka Suzuki

Nucleic Acids Res· July 2017

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Analysis of RNA decay factor mediated RNA stability contributions on RNA abundance.
Sho Maekawa, Naoto Imamachi, Takuma Irie, Hidenori Tani, Kyoko Matsumoto

BMC Genomics· March 2015

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BRIC-seq: a genome-wide approach for determining RNA stability in mammalian cells.
Naoto Imamachi, Hidenori Tani, Rena Mizutani, Katsutoshi Imamura, Takuma Irie

Methods· May 2014

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Linear regression models predicting strength of transcriptional activity of promoters.
Tetsushi Yada, Keigo Yoshida, Masao Morita, Takeaki Taniguchi, Takuma Irie

Genome Inform· December 2013

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Identification of hundreds of novel UPF1 target transcripts by direct determination of whole transcriptome stability.
Hidenori Tani, Naoto Imamachi, Kazi Abdus Salam, Rena Mizutani, Kenichi Ijiri, Takuma Irie

RNA Biol· November 2012

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Predicting promoter activities of primary human DNA sequences.
Takuma Irie, Sung-Joon Park, Riu Yamashita, Masahide Seki, Tetsushi Yada

Nucleic Acids Res· June 2011

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Massive transcriptional start site analysis of human genes in hypoxia cells.
Katsuya Tsuchihara, Yutaka Suzuki, Hiroyuki Wakaguri, Takuma Irie, Kousuke Tanimoto

Nucleic Acids Res· April 2009

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Low conservation and species-specific evolution of alternative splicing in humans and mice: comparative genomics analysis using well-annotated full-length cDNAs.
Jun-Ichi Takeda, Yutaka Suzuki, Ryuichi Sakate, Yoshiharu Sato, Masahide Seki, Takuma Irie

Nucleic Acids Res· November 2008

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Distinct class of putative "non-conserved" promoters in humans: comparative studies of alternative promoters of human and mouse genes.
Katsuki Tsuritani, Takuma Irie, Riu Yamashita, Yuta Sakakibara, Hiroyuki Wakaguri

Genome Res· July 2007

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