Publications by authors named "Tangyang Ji"

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Design, synthesis and bioevaluation of novel combretastatin A-4 based derivatives as potent tubulin/HDAC6 dual-target inhibitors for cancer therapy.
Zhongkai Zou, Tangyang Ji, Yanting Zhang, Jianfan Cai, Yukang Lin

Eur J Med Chem· February 2026

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Structure-Guided Discovery of Novel -(Substituted Thiazol-2-yl)--(4-Substituted phenyl)pyrimidine-2,4-Diamines as Potent CDK2 and CDK9 Dual Inhibitors with High Oral Bioavailability.
Bei Zhang, Yanhong Li, Yukang Lin, Ting Wang, Lin Chen, Jianfan Cai, Tangyang Ji, Jingkao Chen

J Med Chem· January 2025

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Down-regulation of ESRP2 inhibits breast cancer cell proliferation via inhibiting cyclinD1.
Caiping He, Yuting Chen, Ximin Zhang, Huancun Feng, Yuzhen Rao, Tangyang Ji

Sci Rep· November 2024

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Design, synthesis, and biological evaluation of N-(pyridin-3-yl)pyrimidin-4-amine analogues as novel cyclin-dependent kinase 2 inhibitors for cancer therapy.
Wen-Bin Zeng, Tang-Yang Ji, Yan-Ting Zhang, Yu-Feng Ma, Rou Li

Bioorg Chem· February 2024

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Synthesis and biological evaluation of novel 5-substituted/unsubstituted triazolothiadiazines as tubulin depolymerizing and vascular disrupting agents with promising antitumor activity.
Xian-Sen Huo, Ji Tang-Yang, Wen-Bin Zeng, Xie-Er Jian, Xuan-Xuan Ma

Drug Dev Res· August 2023

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Discovery of novel 6-p-tolyl-3-(3,4,5-trimethoxybenzyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine derivative as a potent tubulin inhibitor with promising in vivo antitumor activity.
Tangyang Ji, Xieer Jian, Lin Chen, Wenbin Zeng, Xiansen Huo

Eur J Med Chem· August 2023

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Rational design, synthesis and biological evaluation of novel 2-(substituted amino)-[1,2,4]triazolo[1,5-a]pyrimidines as novel tubulin polymerization inhibitors.
Lin Chen, Tang-Yang Ji, Xian-Sen Huo, Zhi-Yu Zeng, Wei-Xuan Ye

Eur J Med Chem· December 2022

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Efficient synthesis and evaluation of novel 6-arylamino-[1,2,4]triazolo[4,3-a]pyridine derivatives as antiproliferative agents.
Man-Yu Lin, Tang-Yang Ji, Miao Zheng, Yan-Yan Chen, Shi-Yi Xu

Bioorg Med Chem Lett· November 2022

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