Publications by authors named "Tetsuo Obitsu"

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Discovery of Novel Seven-Membered Prostacyclin Analogues as Potent and Selective Prostaglandin FP and EP3 Dual Agonists.
Isamu Sugimoto, Tohru Kambe, Tomotaka Okino, Tetsuo Obitsu, Nobukazu Ohta

ACS Med Chem Lett· January 2017

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Pyrrolo[1,2-b]pyridazines, pyrrolo[2,1-f]triazin-4(3H)-ones, and related compounds as novel corticotropin-releasing factor 1 (CRF₁) receptor antagonists.
Tetsuji Saito, Tetsuo Obitsu, Hiroshi Kohno, Isamu Sugimoto, Takeshi Matsushita

Bioorg Med Chem· January 2012

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Pyrazolo[1,5-a]pyrimidines, triazolo[1,5-a]pyrimidines and their tricyclic derivatives as corticotropin-releasing factor 1 (CRF₁) receptor antagonists.
Tetsuji Saito, Tetsuo Obitsu, Chiaki Minamoto, Tsuneyuki Sugiura, Naoya Matsumura

Bioorg Med Chem· October 2011

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6,7-Dihydro-5H-cyclopenta[d]pyrazolo[1,5-a]pyrimidines and their derivatives as novel corticotropin-releasing factor 1 receptor antagonists.
Tetsuji Saito, Tetsuo Obitsu, Takashi Kondo, Toshiaki Matsui, Yuuki Nagao

Bioorg Med Chem· September 2011

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3-(2-Aminocarbonylphenyl)propanoic acid analogs as potent and selective EP3 receptor antagonists. Part 3: Synthesis, metabolic stability, and biological evaluation of optically active analogs.
Masaki Asada, Tetsuo Obitsu, Atsushi Kinoshita, Toshihiko Nagase, Tadahiro Yoshida

Bioorg Med Chem· May 2010

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Discovery of novel N-acylsulfonamide analogs as potent and selective EP3 receptor antagonists.
Masaki Asada, Tetsuo Obitsu, Atsushi Kinoshita, Yoshihiko Nakai, Toshihiko Nagase

Bioorg Med Chem Lett· April 2010

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3-(2-Aminocarbonylphenyl)propanoic acid analogs as potent and selective EP3 receptor antagonists. part 2: optimization of the side chains to improve in vitro and in vivo potencies.
Masaki Asada, Maki Iwahashi, Tetsuo Obitsu, Atsushi Kinoshita, Yoshihiko Nakai

Bioorg Med Chem· February 2010

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3-(2-Aminocarbonylphenyl)propanoic acid analogs as potent and selective EP3 receptor antagonists. Part 1: discovery and exploration of the carboxyamide side chain.
Masaki Asada, Tetsuo Obitsu, Toshihiko Nagase, Motoyuki Tanaka, Yoshiyuki Yamaura

Bioorg Med Chem· January 2010

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Discovery of a series of acrylic acids and their derivatives as chemical leads for selective EP3 receptor antagonists.
Masaki Asada, Tetsuo Obitsu, Toshihiko Nagase, Isamu Sugimoto, Yoshiyuki Yamaura

Bioorg Med Chem· September 2009

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(-)-(3S)-4-(2-{[4,4-Dimethoxy-6-(benzyloxymethyl)perhydropyran-2-yl]methyl}-1,3-dithian-2-yl)-4-methyl-3-(1,1,2,2-tetramethyl-1-silapropoxy)pentan-1-ol.
Hiroyuki Hosomi, Shigeru Ohba, Ken Ohmori, Tetsuo Obitsu, Yasuyuki Ogawa

Acta Crystallogr C· April 2000

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(+)-3-{(4S,5S)-5-[1,1-Dimethyl-2-(phenylthio)ethyl]-2,2-dimethyl-1,3-dioxolan-4-yl}prop-2-yn-1-ol.
Hiroyuki Hosomi, Shigeru Ohba, Ken Ohmori, Tetsuo Obitsu, Yasuyuki Ogawa

Acta Crystallogr C· April 2000

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