Publications by authors named "Thomas A Gasiewicz"

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Conditional deletion of Ahr alters gene expression profiles in hematopoietic stem cells.
John A Bennett, Kameshwar P Singh, Stephen L Welle, Lisbeth A Boule, B Paige Lawrence, Thomas A Gasiewicz

PLoS One· April 2019

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Aryl Hydrocarbon Receptor and Stem Cells.
Thomas A Gasiewicz, Kameshwar P Singh, Fanny L Casado

Stem Cells Int· January 2017

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Aryl Hydrocarbon Receptor Deficiency in an Exon 3 Deletion Mouse Model Promotes Hematopoietic Stem Cell Proliferation and Impacts Endosteal Niche Cells.
Zeenath Unnisa, Kameshwar P Singh, Ellen C Henry, Catherine L Donegan, John A Bennett, Thomas A Gasiewicz

Stem Cells Int· July 2016

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Deficiency in Aryl Hydrocarbon Receptor (AHR) Expression throughout Aging Alters Gene Expression Profiles in Murine Long-Term Hematopoietic Stem Cells.
John A Bennett, Kameshwar P Singh, Zeenath Unnisa, Stephen L Welle, Thomas A Gasiewicz

PLoS One· May 2016

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The heat shock protein 90 inhibitor, (-)-epigallocatechin gallate, has anticancer activity in a novel human prostate cancer progression model.
Michael A Moses, Ellen C Henry, William A Ricke, Thomas A Gasiewicz

Cancer Prev Res (Phila)· March 2015

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Towards the discovery of drug-like epigallocatechin gallate analogs as Hsp90 inhibitors.
Rohit Bhat, Amna T Adam, Jungeun Jasmine Lee, Thomas A Gasiewicz, Ellen C Henry

Bioorg Med Chem Lett· May 2014

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The Ah receptor in stem cell cycling, regulation, and quiescence.
Thomas A Gasiewicz, Kameshwar P Singh, J Allen Bennett

Ann N Y Acad Sci· March 2014

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Loss of aryl hydrocarbon receptor promotes gene changes associated with premature hematopoietic stem cell exhaustion and development of a myeloproliferative disorder in aging mice.
Kameshwar P Singh, John A Bennett, Fanny L Casado, Jason L Walrath, Stephen L Welle, Thomas A Gasiewicz

Stem Cells Dev· January 2014

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Aryl hydrocarbon receptor activation in hematopoietic stem/progenitor cells alters cell function and pathway-specific gene modulation reflecting changes in cellular trafficking and migration.
Fanny L Casado, Kameshwar P Singh, Thomas A Gasiewicz

Mol Pharmacol· October 2011

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Aryl hydrocarbon receptor-null allele mice have hematopoietic stem/progenitor cells with abnormal characteristics and functions.
Kameshwar P Singh, Russell W Garrett, Fanny L Casado, Thomas A Gasiewicz

Stem Cells Dev· May 2011

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Neural precursor cell proliferation is disrupted through activation of the aryl hydrocarbon receptor by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Sarah E Latchney, Daniel T Lioy, Ellen C Henry, Thomas A Gasiewicz, Frederick G Strathmann

Stem Cells Dev· February 2011

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Identification of stage-specific gene modulation during early thymocyte development by whole-genome profiling analysis after aryl hydrocarbon receptor activation.
Michael D Laiosa, Jeffrey H Mills, Zhi-Wei Lai, Kameshwar P Singh, Frank A Middleton, Thomas A Gasiewicz

Mol Pharmacol· May 2010

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The aryl hydrocarbon receptor: regulation of hematopoiesis and involvement in the progression of blood diseases.
Fanny L Casado, Kameshwar P Singh, Thomas A Gasiewicz

Blood Cells Mol Dis· April 2010

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The aryl hydrocarbon receptor has an important role in the regulation of hematopoiesis: implications for benzene-induced hematopoietic toxicity.
Thomas A Gasiewicz, Kameshwar P Singh, Fanny L Casado

Chem Biol Interact· March 2010

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TCDD and a putative endogenous AhR ligand, ITE, elicit the same immediate changes in gene expression in mouse lung fibroblasts.
Ellen C Henry, Stephen L Welle, Thomas A Gasiewicz

Toxicol Sci· March 2010

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The aryl hydrocarbon receptor has a normal function in the regulation of hematopoietic and other stem/progenitor cell populations.
Kameshwar P Singh, Fanny L Casado, Lisa A Opanashuk, Thomas A Gasiewicz

Biochem Pharmacol· February 2009

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Treatment of mice with the Ah receptor agonist and human carcinogen dioxin results in altered numbers and function of hematopoietic stem cells.
Kameshwar P Singh, Amber Wyman, Fanny L Casado, Russell W Garrett, Thomas A Gasiewicz

Carcinogenesis· January 2009

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(-)-Epigallocatechin-3-gallate is a novel Hsp90 inhibitor.
Zhengyu Yin, Ellen C Henry, Thomas A Gasiewicz

Biochemistry· January 2009

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Dioxin causes ventral prostate agenesis by disrupting dorsoventral patterning in developing mouse prostate.
Chad M Vezina, Sarah Hicks Allgeier, Robert W Moore, Tien-Min Lin, Jeffrey C Bemis, Thomas A Gasiewicz

Toxicol Sci· December 2008

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The aryl hydrocarbon receptor attenuates tobacco smoke-induced cyclooxygenase-2 and prostaglandin production in lung fibroblasts through regulation of the NF-kappaB family member RelB.
Carolyn J Baglole, Sanjay B Maggirwar, Thomas A Gasiewicz, Thomas H Thatcher, Richard P Phipps

J Biol Chem· October 2008

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Expression and activity of aryl hydrocarbon receptors in development and cancer.
Thomas A Gasiewicz, Ellen C Henry, Loretta L Collins

Crit Rev Eukaryot Gene Expr· August 2008

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2,3,7,8-Tetracholorodibenzo-p-dioxin exposure disrupts granule neuron precursor maturation in the developing mouse cerebellum.
Loretta L Collins, Mary A Williamson, Bryan D Thompson, Daniel P Dever, Thomas A Gasiewicz

Toxicol Sci· May 2008

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Environmental toxicants may modulate osteoblast differentiation by a mechanism involving the aryl hydrocarbon receptor.
Elizabeth P Ryan, Jonathan D Holz, Mary Mulcahey, Tzong-Jen Sheu, Thomas A Gasiewicz

J Bone Miner Res· October 2007

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Aryl hydrocarbon receptor-deficient mice develop heightened inflammatory responses to cigarette smoke and endotoxin associated with rapid loss of the nuclear factor-kappaB component RelB.
Thomas H Thatcher, Sanjay B Maggirwar, Carolyn J Baglole, Heather F Lakatos, Thomas A Gasiewicz

Am J Pathol· March 2007

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TCDD-induced alterations in gene expression profiles of the developing mouse paw do not influence morphological differentiation of this potential target tissue.
Jeffrey C Bemis, Napoleon F Alejandro, Daniel A Nazarenko, Andrew I Brooks, Raymond B Baggs, Thomas A Gasiewicz

Toxicol Sci· January 2007

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