Publications by authors named "Thomas Cech"

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RNA-induced PRC2 inhibition depends on the sequence of bound RNA.
Jiarui Song, Liqi Yao, Anne R Gooding, Valentin Thron, Wayne O Hemphill, Thomas R Cech

Res Sq· November 2025

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RNA-induced PRC2 inhibition depends on the sequence of bound RNA.
Jiarui Song, Liqi Yao, Anne R Gooding, Valentin Thron, Wayne O Hemphill, Thomas R Cech

bioRxiv· September 2025

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DHX36 modulates stress granule assembly independent of recruitment of mRNAs with G-quadruplex sequence motifs.
Li Yi Cheng, Nina Ripin, Thomas R Cech, Roy Parker

Nucleic Acids Res· September 2025

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Impact of G-tract RNAs and the DHX36 helicase on stress granule composition and formation.
Li Yi Cheng, Nina Ripin, Thomas R Cech, Roy Parker

bioRxiv· June 2025

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Rapid dynamics allow the low-abundance RTEL1 helicase to promote telomere replication.
Guanhui Wu, Erin Taylor, Daniel T Youmans, Nausica Arnoult, Thomas R Cech

Nucleic Acids Res· February 2025

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Telomerase RNA structural heterogeneity in living human cells detected by DMS-MaPseq.
Nicholas M Forino, Jia Zheng Woo, Arthur J Zaug, Arcelia Gonzalez Jimenez, Eva Edelson, Thomas R Cech

Nat Commun· January 2025

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PRC2-RNA interactions: Viewpoint from Tom Cech, Chen Davidovich, and Richard Jenner.
Thomas R Cech, Chen Davidovich, Richard G Jenner

Mol Cell· October 2024

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Telomerase RNA structural heterogeneity in living human cells detected by DMS-MaPseq.
Nicholas M Forino, Jia Zheng Woo, Arthur J Zaug, Arcelia Gonzalez Jimenez, Eva Edelson, Thomas R Cech

bioRxiv· August 2024

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Small molecule telomerase inhibitors are also potent inhibitors of telomeric C-strand synthesis.
Kaitlin Johnson, Julia M Seidel, Thomas R Cech

RNA· August 2024

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Reflections from Nobel laureates in chemistry.
Thomas R Cech, Emmanuelle Charpentier, Aaron Ciechanover, Robert J Lefkowitz, Kurt Wüthrich

Cell Chem Biol· August 2024

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Transcription factors ERα and Sox2 have differing multiphasic DNA- and RNA-binding mechanisms.
Wayne O Hemphill, Halley R Steiner, Jackson R Kominsky, Deborah S Wuttke, Thomas R Cech

RNA· July 2024

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POT1 recruits and regulates CST-Polα/primase at human telomeres.
Sarah W Cai, Hiroyuki Takai, Arthur J Zaug, Teague C Dilgen, Thomas R Cech

Cell· July 2024

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Evaluation of the RNA-dependence of PRC2 binding to chromatin in human pluripotent stem cells.
Yicheng Long, Taeyoung Hwang, Anne R Gooding, Karen J Goodrich, Skylar D Hanson, Thomas R Cech

bioRxiv· May 2024

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Transcription factors ERα and Sox2 have differing multiphasic DNA and RNA binding mechanisms.
Wayne O Hemphill, Halley R Steiner, Jackson R Kominsky, Deborah S Wuttke, Thomas R Cech

bioRxiv· March 2024

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Telomerase misbehaves after a breakup.
Nausica Arnoult, Thomas R Cech

Science· February 2024

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Structural basis for inactivation of PRC2 by G-quadruplex RNA.
Jiarui Song, Anne R Gooding, Wayne O Hemphill, Brittney D Love, Anne Robertson, Thomas R Cech

Science· September 2023

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PRC2 direct transfer from G-quadruplex RNA to dsDNA has implications for RNA-binding chromatin modifiers.
Wayne O Hemphill, Regan Fenske, Anne R Gooding, Thomas R Cech

Proc Natl Acad Sci U S A· June 2023

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, and diversity in rivers, streams and riparian alder ecosystems of Central Europe.
Tamara Corcobado, Thomas L Cech, Andreas Daxer, Henrieta Ďatková, Josef Janoušek

Mycol Prog· June 2023

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Multiple RNA- and DNA-binding proteins exhibit direct transfer of polynucleotides with implications for target-site search.
Wayne O Hemphill, Calvin K Voong, Regan Fenske, James A Goodrich, Thomas R Cech

Proc Natl Acad Sci U S A· June 2023

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DNMT1 inhibition by pUG-fold quadruplex RNA.
Linnea I Jansson-Fritzberg, Camila I Sousa, Michael J Smallegan, Jessica J Song, Anne R Gooding, Thomas R Cech

RNA· March 2023

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The complexity of transferring genetic information.
Lucia C Strader, Max V Staller, Anne E Willis, Geoffrey J Faulkner, Jean D Beggs, Thomas R Cech

Mol Cell· February 2023

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Structural basis for inactivation of PRC2 by G-quadruplex RNA.
Jiarui Song, Anne R Gooding, Wayne O Hemphill, Vignesh Kasinath, Thomas R Cech

bioRxiv· February 2023

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Diversity, migration routes, and worldwide population genetic structure of Lecanosticta acicola, the causal agent of brown spot needle blight.
Marili Laas, Kalev Adamson, Irene Barnes, Josef Janoušek, Martin S Mullett, Thomas Cech

Mol Plant Pathol· November 2022

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Reconstitution of a telomeric replicon organized by CST.
Arthur J Zaug, Karen J Goodrich, Jessica J Song, Ashley E Sullivan, Thomas R Cech

Nature· August 2022

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Polycomb-mediated genome architecture enables long-range spreading of H3K27 methylation.
Katerina Kraft, Kathryn E Yost, Sedona E Murphy, Andreas Magg, Yicheng Long, Thomas R Cech

Proc Natl Acad Sci U S A· May 2022

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