Publications by authors named "Thomas D Arnold"

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Dynamic fibroblast-immune interactions shape recovery after brain injury.
Nathan A Ewing-Crystal, Nicholas M Mroz, Amara Larpthaveesarp, Carlos O Lizama, Remy Pennington, Thomas D Arnold

Nature· October 2025

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Radial glia integrin avb8 regulates cell autonomous microglial TGFβ1 signaling that is necessary for microglial identity.
Gabriel L McKinsey, Nicolas Santander, Xiaoming Zhang, Kilian L Kleemann, Lauren Tran, Thomas D Arnold

Nat Commun· March 2025

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Microglia are not necessary for maintenance of blood-brain barrier properties in health, but PLX5622 alters brain endothelial cholesterol metabolism.
Caterina P Profaci, Sean S Harvey, Kaja Bajc, Tony Z Zhang, Danielle A Jeffrey, Thomas D Arnold

Neuron· September 2024

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Type-I-interferon-responsive microglia shape cortical development and behavior.
Caroline C Escoubas, Leah C Dorman, Phi T Nguyen, Christian Lagares-Linares, Haruna Nakajo, Thomas D Arnold

Cell· April 2024

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Dynamic fibroblast-immune interactions shape wound healing after brain injury.
Nathan A Ewing-Crystal, Nicholas M Mroz, Anthony A Chang, Eric Dean Merrill, Sofia E Caryotakis, Thomas D Arnold

bioRxiv· March 2024

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PTP1B mediates the inhibitory effect of MFGE8 on insulin signaling through the β5 integrin.
Ritwik Datta, Dibyanti Mukherjee, Michael J Podolsky, Christopher D Yang, Diana L Alba, Thomas D Arnold

J Biol Chem· February 2024

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A comparative evaluation of the strengths and potential caveats of the microglial inducible CreER mouse models.
Alicia M Bedolla, Gabriel L McKinsey, Kierra Ware, Nicolas Santander, Thomas D Arnold

Cell Rep· January 2024

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APOE4 impairs the microglial response in Alzheimer's disease by inducing TGFβ-mediated checkpoints.
Zhuoran Yin, Neta Rosenzweig, Kilian L Kleemann, Xiaoming Zhang, Wesley Brandão, Thomas D Arnold

Nat Immunol· November 2023

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Radial glia promote microglial development through integrin αβ -TGFβ1 signaling.
Gabriel L McKinsey, Nicolas Santander, Xiaoming Zhang, Kilian Kleemann, Lauren Tran, Thomas D Arnold

bioRxiv· September 2023

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Microglia are involved in the protection of memories formed during sleep deprivation.
Nicholas W Gentry, Thomas McMahon, Maya Yamazaki, John Webb, Thomas D Arnold

Neurobiol Sleep Circadian Rhythms· May 2022

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The SARS-CoV-2 receptor ACE2 is expressed in mouse pericytes but not endothelial cells: Implications for COVID-19 vascular research.
Lars Muhl, Liqun He, Ying Sun, Maarja Andaloussi Mäe, Riikka Pietilä, Thomas D Arnold

Stem Cell Reports· May 2022

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αVβ8 integrin targeting to prevent posterior capsular opacification.
Mahbubul H Shihan, Samuel G Novo, Yan Wang, Dean Sheppard, Amha Atakilit, Thomas D Arnold

JCI Insight· November 2021

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Enrichment of Vascular Fragments from Mouse Embryonic Brains for Endothelial Cell Analysis.
Nicolas Santander, Thomas D Arnold

Bio Protoc· June 2021

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CNS fibroblasts form a fibrotic scar in response to immune cell infiltration.
Cayce E Dorrier, Dvir Aran, Ezekiel A Haenelt, Ryan N Sheehy, Kimberly K Hoi, Thomas D Arnold

Nat Neurosci· February 2021

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Lack of Flvcr2 impairs brain angiogenesis without affecting the blood-brain barrier.
Nicolas Santander, Carlos O Lizama, Eman Meky, Gabriel L McKinsey, Bongnam Jung, Thomas D Arnold

J Clin Invest· August 2020

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A new genetic strategy for targeting microglia in development and disease.
Gabriel L McKinsey, Carlos O Lizama, Amber E Keown-Lang, Abraham Niu, Nicolas Santander, Thomas D Arnold

Elife· June 2020

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Disruption of the Extracellular Matrix Progressively Impairs Central Nervous System Vascular Maturation Downstream of β-Catenin Signaling.
Lasse D Jensen, Belma Hot, Daniel Ramsköld, Raoul F V Germano, Chika Yokota, Thomas D Arnold

Arterioscler Thromb Vasc Biol· July 2019

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Impaired αVβ8 and TGFβ signaling lead to microglial dysmaturation and neuromotor dysfunction.
Thomas D Arnold, Carlos O Lizama, Kelly M Cautivo, Nicolas Santander, Lucia Lin

J Exp Med· April 2019

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Visualization of vascular mural cells in developing brain using genetically labeled transgenic reporter mice.
Bongnam Jung, Thomas D Arnold, Elisabeth Raschperger, Konstantin Gaengel, Christer Betsholtz

J Cereb Blood Flow Metab· March 2018

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Tissue Myeloid Progenitors Differentiate into Pericytes through TGF-β Signaling in Developing Skin Vasculature.
Tomoko Yamazaki, Ani Nalbandian, Yutaka Uchida, Wenling Li, Thomas D Arnold

Cell Rep· March 2017

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The αvβ1 integrin plays a critical in vivo role in tissue fibrosis.
Nilgun I Reed, Hyunil Jo, Chun Chen, Kazuyuki Tsujino, Thomas D Arnold

Sci Transl Med· May 2015

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LSR/angulin-1 is a tricellular tight junction protein involved in blood-brain barrier formation.
Fabien Sohet, Christina Lin, Roeben N Munji, Seo Yeon Lee, Nadine Ruderisch, Thomas D Arnold

J Cell Biol· March 2015

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Excessive vascular sprouting underlies cerebral hemorrhage in mice lacking αVβ8-TGFβ signaling in the brain.
Thomas D Arnold, Colin Niaudet, Mei-Fong Pang, Julie Siegenthaler, Konstantin Gaengel

Development· December 2014

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Mesangial cell αvβ8-integrin regulates glomerular capillary integrity and repair.
Sujata Lakhe-Reddy, Vincent Li, Thomas D Arnold, Shenaz Khan, Jeffrey R Schelling

Am J Physiol Renal Physiol· June 2014

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Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs.
Neil C Henderson, Thomas D Arnold, Yoshio Katamura, Marilyn M Giacomini, Juan D Rodriguez

Nat Med· December 2013

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