Publications by authors named "Thomas D Hurley"

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Impaired malin expression and interaction with partner proteins in Lafora disease.
Alexander V Skurat, Dyann M Segvich, Christopher J Contreras, Yueh-Chiang Hu, Thomas D Hurley

J Biol Chem· May 2024

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Development of substituted benzimidazoles as inhibitors of human aldehyde dehydrogenase 1A isoenzymes.
Cyrus Takahashi, Mikhail Chtcherbinine, Brandt C Huddle, Michael W Wilson, Timothy Emmel, Thomas D Hurley

Chem Biol Interact· March 2024

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Small-molecule inhibition of glycogen synthase 1 for the treatment of Pompe disease and other glycogen storage disorders.
Julie C Ullman, Kevin T Mellem, Yannan Xi, Vyas Ramanan, Hanne Merritt, Thomas D Hurley

Sci Transl Med· January 2024

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The structural mechanism of human glycogen synthesis by the GYS1-GYG1 complex.
Nathan M Fastman, Yuxi Liu, Vyas Ramanan, Hanne Merritt, Eileen Ambing, Thomas D Hurley

Cell Rep· July 2022

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A Novel ALDH1A1 Inhibitor Blocks Platinum-Induced Senescence and Stemness in Ovarian Cancer.
Vaishnavi Muralikrishnan, Fang Fang, Tyler C Given, Ram Podicheti, Mikhail Chtcherbinine, Thomas D Hurley

Cancers (Basel)· July 2022

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Brain glycogen serves as a critical glucosamine cache required for protein glycosylation.
Ramon C Sun, Lyndsay E A Young, Ronald C Bruntz, Kia H Markussen, Zhengqiu Zhou, Thomas D Hurley

Cell Metab· July 2021

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Development of 2,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one inhibitors of aldehyde dehydrogenase 1A (ALDH1A) as potential adjuncts to ovarian cancer chemotherapy.
Brandt C Huddle, Edward Grimley, Mikhail Chtcherbinine, Cameron D Buchman, Cyrus Takahashi, Thomas D Hurley

Eur J Med Chem· February 2021

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Discovery and Development of Small-Molecule Inhibitors of Glycogen Synthase.
Buyun Tang, Mykhaylo S Frasinyuk, Vimbai M Chikwana, Krishna K Mahalingan, Cynthia A Morgan, Thomas D Hurley

J Med Chem· April 2020

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Targeting Aldehyde Dehydrogenases to Eliminate Cancer Stem Cells in Gynecologic Malignancies.
Vaishnavi Muralikrishnan, Thomas D Hurley, Kenneth P Nephew

Cancers (Basel)· April 2020

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The 5th International Lafora Epilepsy Workshop: Basic science elucidating therapeutic options and preparing for therapies in the clinic.
Matthew S Gentry, Zaid Afawi, Dustin D Armstrong, Antonio Delgado-Escueta, Y Paul Goldberg, Thomas D Hurley

Epilepsy Behav· February 2020

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A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells.
Ilana Chefetz, Edward Grimley, Kun Yang, Linda Hong, Ekaterina V Vinogradova, Thomas D Hurley

Cell Rep· March 2019

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ALDH1 Bio-activates Nifuroxazide to Eradicate ALDH Melanoma-Initiating Cells.
Sana Sarvi, Richard Crispin, Yuting Lu, Lifan Zeng, Thomas D Hurley

Cell Chem Biol· December 2018

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Structure-Based Optimization of a Novel Class of Aldehyde Dehydrogenase 1A (ALDH1A) Subfamily-Selective Inhibitors as Potential Adjuncts to Ovarian Cancer Chemotherapy.
Brandt C Huddle, Edward Grimley, Cameron D Buchman, Mikhail Chtcherbinine, Bikash Debnath, Thomas D Hurley

J Med Chem· October 2018

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Lipid Desaturation Is a Metabolic Marker and Therapeutic Target of Ovarian Cancer Stem Cells.
Junjie Li, Salvatore Condello, Jessica Thomes-Pepin, Xiaoxiao Ma, Yu Xia, Thomas D Hurley

Cell Stem Cell· March 2017

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Inhibition of the Aldehyde Dehydrogenase 1/2 Family by Psoralen and Coumarin Derivatives.
Cameron D Buchman, Thomas D Hurley

J Med Chem· March 2017

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Redox Switch for the Inhibited State of Yeast Glycogen Synthase Mimics Regulation by Phosphorylation.
Krishna K Mahalingan, Sulochanadevi Baskaran, Anna A DePaoli-Roach, Peter J Roach, Thomas D Hurley

Biochemistry· January 2017

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Incorporation of phosphate into glycogen by glycogen synthase.
Christopher J Contreras, Dyann M Segvich, Krishna Mahalingan, Vimbai M Chikwana, Terence L Kirley, Thomas D Hurley

Arch Biochem Biophys· May 2016

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Development of a high-throughput in vitro assay to identify selective inhibitors for human ALDH1A1.
Cynthia A Morgan, Thomas D Hurley

Chem Biol Interact· June 2015

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N,N-diethylaminobenzaldehyde (DEAB) as a substrate and mechanism-based inhibitor for human ALDH isoenzymes.
Cynthia A Morgan, Bibek Parajuli, Cameron D Buchman, Karl Dria, Thomas D Hurley

Chem Biol Interact· June 2015

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Discovery of a series of aromatic lactones as ALDH1/2-directed inhibitors.
Cameron D Buchman, Krishna K Mahalingan, Thomas D Hurley

Chem Biol Interact· June 2015

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Characterization of two distinct structural classes of selective aldehyde dehydrogenase 1A1 inhibitors.
Cynthia A Morgan, Thomas D Hurley

J Med Chem· February 2015

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Hominids adapted to metabolize ethanol long before human-directed fermentation.
Matthew A Carrigan, Oleg Uryasev, Carole B Frye, Blair L Eckman, Candace R Myers, Thomas D Hurley

Proc Natl Acad Sci U S A· January 2015

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Enrichment of chemical libraries docked to protein conformational ensembles and application to aldehyde dehydrogenase 2.
Bo Wang, Cameron D Buchman, Liwei Li, Thomas D Hurley, Samy O Meroueh

J Chem Inf Model· July 2014

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Development of selective inhibitors for human aldehyde dehydrogenase 3A1 (ALDH3A1) for the enhancement of cyclophosphamide cytotoxicity.
Bibek Parajuli, Taxiarchis M Georgiadis, Melissa L Fishel, Thomas D Hurley

Chembiochem· March 2014

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Development of selective inhibitors for aldehyde dehydrogenases based on substituted indole-2,3-diones.
Ann C Kimble-Hill, Bibek Parajuli, Che-Hong Chen, Daria Mochly-Rosen, Thomas D Hurley

J Med Chem· February 2014

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