Publications by authors named "Thomas D Meek"

Claim this Profile
D
Dual Inhibitors of SARS-CoV-2 3CL Protease and Human Cathepsin L Containing Glutamine Isosteres Are Anti-CoV-2 Agents.
Vivek Kumar, Jiyun Zhu, Bala C Chenna, Zoe A Hoffpauir, Andrew Rademacher, Thomas D Meek

J Am Chem Soc· January 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Catalytic Mechanism of SARS-CoV-2 3-Chymotrypsin-Like Protease as Determined by Steady-State and Pre-Steady-State Kinetics.
Jiyun Zhu, Alexandria M Kemp, Bala C Chenna, Vivek Kumar, Andrew Rademacher, Thomas D Meek

ACS Catal· December 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Insights into the Main Protease of SARS-CoV-2: Thermodynamic Analysis, Structural Characterization, and the Impact of Inhibitors.
Jamie P Butalewicz, Sarah N Sipe, Kyle J Juetten, Virginia K James, Kangsan Kim, Thomas D Meek

Anal Chem· October 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
K
Kinetic and Structural Characterization of Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferases and Repurposing of Transition-State Analogue Inhibitors.
Kayla Glockzin, Kathleen M Meneely, Ryan Hughes, Sean W Maatouk, Grace E Piña, Thomas D Meek

Biochemistry· July 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
The design of protozoan phosphoribosyltransferase inhibitors containing non-charged phosphate mimic residues.
Sinan Gai, Kajitha Suthagar, Karl J Shaffer, Wanting Jiao, Yacoba V T Minnow, Thomas D Meek

Bioorg Med Chem· November 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
K
Kinetic Characterization and Inhibition of Hypoxanthine-Guanine Phosphoribosyltransferases.
Kayla Glockzin, Demetrios Kostomiris, Yacoba V T Minnow, Kajitha Suthagar, Keith Clinch, Thomas D Meek

Biochemistry· October 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Self-Masked Aldehyde Inhibitors of Human Cathepsin L Are Potent Anti-CoV-2 Agents.
Jiyun Zhu, Linfeng Li, Aleksandra Drelich, Bala C Chenna, Drake M Mellott, Thomas D Meek

Front Chem· July 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L.
Anneliese S Ashhurst, Arthur H Tang, Pavla Fajtová, Michael C Yoon, Anupriya Aggarwal, Thomas D Meek

J Med Chem· February 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Characterization of adenine phosphoribosyltransferase (APRT) activity in Trypanosoma brucei brucei: Only one of the two isoforms is kinetically active.
Kayla Glockzin, Thomas D Meek, Ardala Katzfuss

PLoS Negl Trop Dis· February 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
Mechanism-Based Inactivation of Isocitrate Lyase 1 by (2,3)-2-Hydroxy-3-(nitromethyl)succinic acid.
Drake M Mellott, Dan Torres, Inna V Krieger, Scott A Cameron, Zahra Moghadamchargari, Thomas D Meek

J Am Chem Soc· October 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Self-Masked Aldehyde Inhibitors: A Novel Strategy for Inhibiting Cysteine Proteases.
Linfeng Li, Bala C Chenna, Kai S Yang, Taylor R Cole, Zachary T Goodall, Thomas D Meek

J Med Chem· August 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Dinitrosyl iron complexes (DNICs) as inhibitors of the SARS-CoV-2 main protease.
D Chase Pectol, Christopher R DeLaney, Jiyun Zhu, Drake M Mellott, Ardala Katzfuss, Thomas D Meek

Chem Commun (Camb)· August 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A Clinical-Stage Cysteine Protease Inhibitor blocks SARS-CoV-2 Infection of Human and Monkey Cells.
Drake M Mellott, Chien-Te Tseng, Aleksandra Drelich, Pavla Fajtová, Bala C Chenna, Thomas D Meek

ACS Chem Biol· April 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Covalent Inactivation of Isocitrate Lyase by -2,3-Epoxy-Succinic Acid.
Truc Viet Pham, Drake M Mellott, Zahra Moghadamchargari, Kevin Chen, Inna Krieger, Thomas D Meek

ACS Chem Biol· March 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Inhibiting Sialidase-Induced TGF-1 Activation Attenuates Pulmonary Fibrosis in Mice.
Tejas R Karhadkar, Thomas D Meek, Richard H Gomer

J Pharmacol Exp Ther· January 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Potent anti-SARS-CoV-2 activity by gallinamide A and analogues via inhibition of cathepsin L.
Anneliese S Ashhurst, Arthur H Tang, Pavla Fajtová, Michael Yoon, Anupriya Aggarwal, Thomas D Meek

bioRxiv· December 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A cysteine protease inhibitor blocks SARS-CoV-2 infection of human and monkey cells.
Drake M Mellott, Chien-Te Tseng, Aleksandra Drelich, Pavla Fajtová, Bala C Chenna, Thomas D Meek

bioRxiv· October 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Peptidomimetic Vinyl Heterocyclic Inhibitors of Cruzain Effect Antitrypanosomal Activity.
Bala C Chenna, Linfeng Li, Drake M Mellott, Xiang Zhai, Jair L Siqueira-Neto, Thomas D Meek

J Med Chem· March 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Enhanced Antibiotic Discovery by PROSPECTing.
Vern L Schramm, Thomas D Meek

Biochemistry· August 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Application of Dually Activated Michael Acceptor to the Rational Design of Reversible Covalent Inhibitor for Enterovirus 71 3C Protease.
Yuying Ma, Linfeng Li, Shuai He, Chengyou Shang, Yang Sun, Thomas D Meek

J Med Chem· July 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Catalytic Mechanism of Cruzain from Trypanosoma cruzi As Determined from Solvent Kinetic Isotope Effects of Steady-State and Pre-Steady-State Kinetics.
Xiang Zhai, Thomas D Meek

Biochemistry· June 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
Mechanistic enzymology in drug discovery: a fresh perspective.
Geoffrey A Holdgate, Thomas D Meek, Rachel L Grimley

Nat Rev Drug Discov· February 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
Mechanistic enzymology in drug discovery: a fresh perspective.
Geoffrey A Holdgate, Thomas D Meek, Rachel L Grimley

Nat Rev Drug Discov· January 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
Mechanism-based inactivator of isocitrate lyases 1 and 2 from .
Truc V Pham, Andrew S Murkin, Margaret M Moynihan, Lawrence Harris, Peter C Tyler, Thomas D Meek

Proc Natl Acad Sci U S A· July 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Transition state for the NSD2-catalyzed methylation of histone H3 lysine 36.
Myles B Poulin, Jessica L Schneck, Rosalie E Matico, Patrick J McDevitt, Michael J Huddleston, Thomas D Meek

Proc Natl Acad Sci U S A· February 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis