Publications by authors named "Thomas Germe"

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Rapid, DNA-induced interface swapping by DNA gyrase.
Thomas R M Germe, Natassja G Bush, Victoria M Baskerville, Dominik Saman, Justin L P Benesch

Elife· June 2024

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design of type II topoisomerase inhibitors as potential antimicrobial agents targeting a novel binding region.
Kyle M Orritt, Lipeng Feng, Juliette F Newell, Jack N Sutton, Scott Grossman, Thomas Germe

RSC Med Chem· July 2022

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Potent DNA gyrase inhibitors bind asymmetrically to their target using symmetrical bifurcated halogen bonds.
Anja Kolarič, Thomas Germe, Martina Hrast, Clare E M Stevenson, David M Lawson

Nat Commun· January 2021

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DNA Topoisomerase Inhibitors: Trapping a DNA-Cleaving Machine in Motion.
Benjamin D Bax, Garib Murshudov, Anthony Maxwell, Thomas Germe

J Mol Biol· August 2019

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A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance.
Thomas Germe, Judit Vörös, Frederic Jeannot, Thomas Taillier, Robert A Stavenger

Nucleic Acids Res· May 2018

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A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance.
Thomas Germe, Judit Vörös, Frederic Jeannot, Thomas Taillier, Robert A Stavenger

Nucleic Acids Res· May 2018

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Imidazopyrazinones (IPYs): Non-Quinolone Bacterial Topoisomerase Inhibitors Showing Partial Cross-Resistance with Quinolones.
Frédéric Jeannot, Thomas Taillier, Pierre Despeyroux, Stéphane Renard, Astrid Rey, Thomas Germe

J Med Chem· April 2018

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Thiophene antibacterials that allosterically stabilize DNA-cleavage complexes with DNA gyrase.
Pan F Chan, Thomas Germe, Benjamin D Bax, Jianzhong Huang, Reema K Thalji

Proc Natl Acad Sci U S A· May 2017

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DNA topoisomerase IIα controls replication origin cluster licensing and firing time in Xenopus egg extracts.
Vincent Gaggioli, Barbara Le Viet, Thomas Germe, Olivier Hyrien

Nucleic Acids Res· August 2013

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A non-canonical function of topoisomerase II in disentangling dysfunctional telomeres.
Thomas Germe, Kyle Miller, Julia Promisel Cooper

EMBO J· September 2009

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DNA replication timing is deterministic at the level of chromosomal domains but stochastic at the level of replicons in Xenopus egg extracts.
Hélène Labit, Irène Perewoska, Thomas Germe, Olivier Hyrien, Kathrin Marheineke

Nucleic Acids Res· October 2008

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Topoisomerase II-DNA complexes trapped by ICRF-193 perturb chromatin structure.
Thomas Germe, Olivier Hyrien

EMBO Rep· August 2005

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