Publications by authors named "Thomas Grunt"

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Understanding cancer from a biophysical, developmental and systems biology perspective using the landscapes-attractor model.
Thomas W Grunt

Biosystems· January 2025

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Today's cancer research and treatment - highly sophisticated and molecularly targeted, yet firmly bolstered in the classical theories.
Thomas W Grunt

J Appl Biomed· September 2024

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Targeting endogenous fatty acid synthesis stimulates the migration of ovarian cancer cells to adipocytes and promotes the transport of fatty acids from adipocytes to cancer cells.
Thomas W Grunt, Renate Wagner, Alexander Ries, Anna S Berghoff, Matthias Preusser

Int J Oncol· March 2024

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Vienna Cancer Stem Cell Club (VCSCC): 20 year jubilee and future perspectives.
Peter Valent, Irina Sadovnik, Barbara Peter, Daniel Ivanov, Axel Schulenburg, Thomas W Grunt

Expert Rev Hematol· November 2023

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A critical appraisal of the relative contribution of tissue architecture, genetics, epigenetics and cell metabolism to carcinogenesis.
Thomas W Grunt, Gerwin Heller

Prog Biophys Mol Biol· September 2023

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Pharmacological Inhibition of Lipid Import and Transport Proteins in Ovarian Cancer.
Lisa Lemberger, Renate Wagner, Gerwin Heller, Dietmar Pils, Thomas W Grunt

Cancers (Basel)· December 2022

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Cancer - A devastating disease, but also an eye-opener and window into the deep mysteries of life and its origins.
Thomas W Grunt, Peter Valent

Prog Biophys Mol Biol· November 2022

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The Pharmacological or Genetic Blockade of Endogenous Fatty Acid Synthesis Does Not Increase the Uptake of Exogenous Lipids in Ovarian Cancer Cells.
Thomas W Grunt, Lisa Lemberger, Ramón Colomer, María Luz López Rodríguez, Renate Wagner

Front Oncol· April 2021

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Degradation of BRD4 - a promising treatment approach not only for hematologic but also for solid cancer.
Karin Bauer, Anna S Berghoff, Matthias Preusser, Gerwin Heller, Christoph C Zielinski, Thomas W Grunt

Am J Cancer Res· February 2021

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Membrane disruption, but not metabolic rewiring, is the key mechanism of anticancer-action of FASN-inhibitors: a multi-omics analysis in ovarian cancer.
Thomas W Grunt, Astrid Slany, Mariya Semkova, Ramón Colomer, María Luz López-Rodríguez

Sci Rep· September 2020

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Correction: Heterotypic CAF-tumor spheroids promote early peritoneal metastatis of ovarian cancer.
Qinglei Gao, Zongyuan Yang, Sen Xu, Xiaoting Li, Xin Yang, Thomas W Grunt

J Exp Med· October 2019

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Heterotypic CAF-tumor spheroids promote early peritoneal metastatis of ovarian cancer.
Qinglei Gao, Zongyuan Yang, Sen Xu, Xiaoting Li, Xin Yang, Thomas W Grunt

J Exp Med· March 2019

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Differential expression of mTOR components in endometriosis and ovarian cancer: Effects of rapalogues and dual kinase inhibitors on mTORC1 and mTORC2 stoichiometry.
Karly-Rai Rogers-Broadway, Juhi Kumar, Cristina Sisu, Gurleen Wander, Emily Mazey, Thomas Grunt

Int J Mol Med· January 2019

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Ludwig Boltzmann Cluster Oncology (LBC ONC): first 10 years and future perspectives.
Peter Valent, Emir Hadzijusufovic, Thomas Grunt, Heidrun Karlic, Barbara Peter

Wien Klin Wochenschr· September 2018

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Hitting two oncogenic machineries in cancer cells: cooperative effects of the multi-kinase inhibitor ponatinib and the BET bromodomain blockers JQ1 or dBET1 on human carcinoma cells.
Karin Bauer, Daniela Berger, Christoph C Zielinski, Peter Valent, Thomas W Grunt

Oncotarget· May 2018

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Interacting Cancer Machineries: Cell Signaling, Lipid Metabolism, and Epigenetics.
Thomas W Grunt

Trends Endocrinol Metab· February 2018

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Estradiol impairs the antiproliferative and proapoptotic effect of Zoledronic acid in hormone sensitive breast cancer cells in vitro.
Daphne Gschwantler-Kaulich, Sigrid Weingartshofer, Thomas W Grunt, Mario Mairhofer, Yen Tan

PLoS One· October 2017

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Long term storage in liquid nitrogen leads to only minor phenotypic and gene expression changes in the mammary carcinoma model cell line BT474.
Judit Fazekas, Thomas W Grunt, Erika Jensen-Jarolim, Josef Singer

Oncotarget· May 2017

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Comparative transcriptome analysis links distinct peritoneal tumor spread types, miliary and non-miliary, with putative origin, tubes and ovaries, in high grade serous ovarian cancer.
Katharina Auer, Anna Bachmayr-Heyda, Stefanie Aust, Thomas W Grunt, Dietmar Pils

Cancer Lett· March 2017

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Multi-level suppression of receptor-PI3K-mTORC1 by fatty acid synthase inhibitors is crucial for their efficacy against ovarian cancer cells.
Renate Wagner, Gerald Stübiger, Daniel Veigel, Michael Wuczkowski, Peter Lanzerstorfer, Thomas W Grunt

Oncotarget· February 2017

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HER Specific TKIs Exert Their Antineoplastic Effects on Breast Cancer Cell Lines through the Involvement of STAT5 and JNK.
Daphne Gschwantler-Kaulich, Thomas W Grunt, Daniela Muhr, Renate Wagner, Heinz Kölbl

PLoS One· July 2016

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Prominin-1 (CD133, AC133) and dipeptidyl-peptidase IV (CD26) are indicators of infinitive growth in colon cancer cells.
Thomas W Grunt, Alexandra Hebar, Sylvia Laffer, Renate Wagner, Barbara Peter

Am J Cancer Res· May 2015

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Inhibition of the mevalonate pathway affects epigenetic regulation in cancer cells.
Heidrun Karlic, Roman Thaler, Christopher Gerner, Thomas Grunt, Katharina Proestling

Cancer Genet· May 2015

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Cancer stem cells in basic science and in translational oncology: can we translate into clinical application?
Axel Schulenburg, Katharina Blatt, Sabine Cerny-Reiterer, Irina Sadovnik, Harald Herrmann, Thomas W Grunt

J Hematol Oncol· February 2015

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Correlation of circular RNA abundance with proliferation--exemplified with colorectal and ovarian cancer, idiopathic lung fibrosis, and normal human tissues.
Anna Bachmayr-Heyda, Agnes T Reiner, Katharina Auer, Nyamdelger Sukhbaatar, Stefanie Aust, Thomas W Grunt

Sci Rep· January 2015

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