Publications by authors named "Thomas Helland"

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Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Thomas Helland

Mol Oncol· November 2025

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Nonlinear Mixed-Effects Model of Z-Endoxifen Concentrations in Tamoxifen-Treated Patients from the CEPAM Cohort.
Anna M Mc Laughlin, Thomas Helland, Fenja Klima, Stijn L W Koolen, Ron H N van Schaik

Clin Pharmacol Ther· September 2024

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Quantitative proteomics reveals serum proteome alterations during metastatic disease progression in breast cancer patients.
Jaspreet Kaur, Sung Yun Jung, Marie Austdal, Aaditya Krishna Arun, Thomas Helland

Clin Proteomics· July 2024

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A randomized Phase I pre-operative window trial of transdermal endoxifen in women planning mastectomy: Evaluation of dermal safety, intra-mammary drug distribution, and biologic effects.
Oukseub Lee, Latifa A Bazzi, Yanfei Xu, Erik Pearson, Minhua Wang, Thomas Helland

Biomed Pharmacother· February 2024

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Presurgical Oral Tamoxifen vs Transdermal 4-Hydroxytamoxifen in Women With Ductal Carcinoma In Situ: A Randomized Clinical Trial.
Seema A Khan, Xinlei Mi, Yanfei Xu, Luis Z Blanco, Azza M Akasha, Thomas Helland

JAMA Surg· December 2023

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Importance of endocrine treatment adherence and persistence in breast cancer survivorship: a systematic review.
Finn Magnus Eliassen, Vibeke Blåfjelldal, Thomas Helland, Cathrine Fonnesbech Hjorth, Kari Hølland

BMC Cancer· July 2023

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Simultaneous Quantification of Aromatase Inhibitors and Estrogens in Postmenopausal Breast Cancer Patients.
Bjørn-Erik Bertelsen, Kristin Viste, Thomas Helland, Magnus Hagland, Håvard Søiland

J Clin Endocrinol Metab· April 2022

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Liquid biopsies and patient-reported outcome measures for integrative monitoring of patients with early-stage breast cancer: a study protocol for the longitudinal observational Prospective Breast Cancer Biobanking (PBCB) study.
Håvard Søiland, Emiel A M Janssen, Thomas Helland, Finn Magnus Eliassen, Magnus Hagland

BMJ Open· April 2022

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Effect of Genetic Variability in 20 Pharmacogenes on Concentrations of Tamoxifen and Its Metabolites.
Yuanhuang Chen, Lauren A Marcath, Finn Magnus Eliassen, Tone Hoel Lende, Havard Soiland, Thomas Helland

J Pers Med· June 2021

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Low Z-4OHtam concentrations are associated with adverse clinical outcome among early stage premenopausal breast cancer patients treated with adjuvant tamoxifen.
Thomas Helland, Bjørn Naume, Steinar Hustad, Ersilia Bifulco, Jan Terje Kvaløy

Mol Oncol· April 2021

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Association of CYP2D6 genotype and tamoxifen metabolites with breast cancer recurrence in a low-dose trial.
Andrea DeCensi, Harriet Johansson, Thomas Helland, Matteo Puntoni, Debora Macis

NPJ Breast Cancer· March 2021

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Generating a Precision Endoxifen Prediction Algorithm to Advance Personalized Tamoxifen Treatment in Patients with Breast Cancer.
Thomas Helland, Sarah Alsomairy, Chenchia Lin, Håvard Søiland, Gunnar Mellgren

J Pers Med· March 2021

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First-in-human pharmacokinetics of tamoxifen and its metabolites in the milk of a lactating mother: a case study.
Fedro Alessandro Peccatori, Giovanni Codacci-Pisanelli, Gunnar Mellgren, Barbara Buonomo, Eleonora Baldassarre, Thomas Helland

ESMO Open· October 2020

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Drug monitoring of tamoxifen metabolites predicts vaginal dryness and verifies a low discontinuation rate from the Norwegian Prescription Database.
Thomas Helland, Kari Britt Hagen, Martha Eimstad Haugstøyl, Jan Terje Kvaløy, Siri Lunde

Breast Cancer Res Treat· August 2019

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A novel SRC-2-dependent regulation of epithelial-mesenchymal transition in breast cancer cells.
Olivera Bozickovic, Linn Skartveit, Agnete S T Engelsen, Thomas Helland, Kristin Jonsdottir

J Steroid Biochem Mol Biol· January 2019

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Serum concentrations of active tamoxifen metabolites predict long-term survival in adjuvantly treated breast cancer patients.
Thomas Helland, Nina Henne, Ersilia Bifulco, Bjørn Naume, Elin Borgen

Breast Cancer Res· November 2017

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Angiopoietin-like protein 8/betatrophin as a new determinant of type 2 diabetes remission after bariatric surgery.
Miriam Ejarque, Marianne Borlaug, Nuria Vilarrasa, Bruno Martinez-Perez, Gemma Llauradó, Thomas Helland

Transl Res· June 2017

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The active tamoxifen metabolite endoxifen (4OHNDtam) strongly down-regulates cytokeratin 6 (CK6) in MCF-7 breast cancer cells.
Thomas Helland, Jennifer Gjerde, Simon Dankel, Ingvild S Fenne, Linn Skartveit

PLoS One· March 2016

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Cyclin C interacts with steroid receptor coactivator 2 and upregulates cell cycle genes in MCF-7 cells.
Olivera Bozickovic, Tuyen Hoang, Ingvild S Fenne, Thomas Helland, Linn Skartveit

Biochim Biophys Acta· October 2015

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Downregulation of steroid receptor coactivator-2 modulates estrogen-responsive genes and stimulates proliferation of mcf-7 breast cancer cells.
Ingvild S Fenne, Thomas Helland, Marianne H Flågeng, Simon N Dankel, Gunnar Mellgren

PLoS One· April 2014

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