Publications by authors named "Thomas Kuilman"

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Enabling next-generation engineered TCR-T therapies based on high-throughput TCR discovery from diagnostic tumor biopsies.
Thomas Kuilman, Deborah S Schrikkema, Jules Gadiot, Raquel Gomez-Eerland, Laura Bies

Nat Commun· January 2025

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The Elongin BC Complex Negatively Regulates AXL and Marks a Differentiated Phenotype in Melanoma.
Sebastiaan M Schieven, Joleen J H Traets, Alex V Vliet, Martijn V Baalen, Ji-Ying Song, Thomas Kuilman

Mol Cancer Res· May 2023

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An adverse tumor-protective effect of IDO1 inhibition.
Juliana C N Kenski, Xinyao Huang, David W Vredevoogd, Beaunelle de Bruijn, Joleen J H Traets, Thomas Kuilman

Cell Rep Med· February 2023

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is commonly amplified and high expression in cancer cells correlates with poor immune checkpoint blockade response.
Sofía Ibáñez-Molero, Alex van Vliet, Joanna Pozniak, Karlijn Hummelink, Alexandra M Terry, Thomas Kuilman

Oncoimmunology· December 2022

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RNF31 inhibition sensitizes tumors to bystander killing by innate and adaptive immune cells.
Zhengkui Zhang, Xiangjun Kong, Maarten A Ligtenberg, Susan E van Hal-van Veen, Nils L Visser, Thomas Kuilman

Cell Rep Med· June 2022

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Predictive Immune-Checkpoint Blockade Classifiers Identify Tumors Responding to Inhibition of PD-1 and/or CTLA-4.
Oscar Krijgsman, Kristel Kemper, Julia Boshuizen, David W Vredevoogd, Elisa A Rozeman, Thomas Kuilman

Clin Cancer Res· October 2021

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Absence of PD-L1 expression on tumor cells in the context of an activated immune infiltrate may indicate impaired IFNγ signaling in non-small cell lung cancer.
Willemijn S M E Theelen, Thomas Kuilman, Katja Schulze, Wei Zou, Oscar Krijgsman

PLoS One· January 2020

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Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold.
David W Vredevoogd, Thomas Kuilman, Maarten A Ligtenberg, Julia Boshuizen, Kelly E Stecker

Cell· January 2020

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Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold.
David W Vredevoogd, Thomas Kuilman, Maarten A Ligtenberg, Julia Boshuizen, Kelly E Stecker

Cell· July 2019

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XenofilteR: computational deconvolution of mouse and human reads in tumor xenograft sequence data.
Roelof J C Kluin, Kristel Kemper, Thomas Kuilman, Julian R de Ruiter, Vivek Iyer

BMC Bioinformatics· October 2018

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Cooperative targeting of melanoma heterogeneity with an AXL antibody-drug conjugate and BRAF/MEK inhibitors.
Julia Boshuizen, Louise A Koopman, Oscar Krijgsman, Aida Shahrabi, Elke Gresnigt- van den Heuvel, Thomas Kuilman

Nat Med· February 2018

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Cancer drug addiction is relayed by an ERK2-dependent phenotype switch.
Xiangjun Kong, Thomas Kuilman, Aida Shahrabi, Julia Boshuizen, Kristel Kemper

Nature· October 2017

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Phenotypic diversity drives paracrine drug tolerance.
Thomas Kuilman, Daniel S Peeper

EMBO Mol Med· August 2017

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Transcription Factor NFIB Is a Driver of Small Cell Lung Cancer Progression in Mice and Marks Metastatic Disease in Patients.
Ekaterina A Semenova, Min-Chul Kwon, Kim Monkhorst, Ji-Ying Song, Rajith Bhaskaran, Thomas Kuilman

Cell Rep· July 2016

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Neoadjuvant tamoxifen synchronizes ERα binding and gene expression profiles related to outcome and proliferation.
Tesa M Severson, Ekaterina Nevedomskaya, Justine Peeters, Thomas Kuilman, Oscar Krijgsman

Oncotarget· June 2016

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BRAF(V600E) Kinase Domain Duplication Identified in Therapy-Refractory Melanoma Patient-Derived Xenografts.
Kristel Kemper, Oscar Krijgsman, Xiangjun Kong, Paulien Cornelissen-Steijger, Aida Shahrabi, Thomas Kuilman

Cell Rep· June 2016

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Preserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastases.
Fleur Weeber, Marc van de Wetering, Marlous Hoogstraat, Krijn K Dijkstra, Oscar Krijgsman, Thomas Kuilman

Proc Natl Acad Sci U S A· October 2015

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Intra- and inter-tumor heterogeneity in a vemurafenib-resistant melanoma patient and derived xenografts.
Kristel Kemper, Oscar Krijgsman, Paulien Cornelissen-Steijger, Aida Shahrabi, Fleur Weeber, Thomas Kuilman

EMBO Mol Med· September 2015

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Robust BRCA1-like classification of copy number profiles of samples repeated across different datasets and platforms.
Philip C Schouten, Anita Grigoriadis, Thomas Kuilman, Hasan Mirza, Johnathan A Watkins

Mol Oncol· August 2015

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Detailed imaging and genetic analysis reveal a secondary BRAF(L505H) resistance mutation and extensive intrapatient heterogeneity in metastatic BRAF mutant melanoma patients treated with vemurafenib.
Marlous Hoogstraat, Christa G Gadellaa-van Hooijdonk, Inge Ubink, Nicolle J M Besselink, Mark Pieterse, Thomas Kuilman

Pigment Cell Melanoma Res· May 2015

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CopywriteR: DNA copy number detection from off-target sequence data.
Thomas Kuilman, Arno Velds, Kristel Kemper, Marco Ranzani, Lorenzo Bombardelli

Genome Biol· February 2015

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Identification of Cdk targets that control cytokinesis.
Thomas Kuilman, Alessio Maiolica, Molly Godfrey, Noémie Scheidel, Ruedi Aebersold

EMBO J· January 2015

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Nur1 dephosphorylation confers positive feedback to mitotic exit phosphatase activation in budding yeast.
Molly Godfrey, Thomas Kuilman, Frank Uhlmann

PLoS Genet· January 2015

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TRF2 inhibits a cell-extrinsic pathway through which natural killer cells eliminate cancer cells.
Annamaria Biroccio, Julien Cherfils-Vicini, Adeline Augereau, Sébastien Pinte, Serge Bauwens, Thomas Kuilman

Nat Cell Biol· July 2013

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The essence of senescence.
Thomas Kuilman, Chrysiis Michaloglou, Wolter J Mooi, Daniel S Peeper

Genes Dev· November 2010

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