Publications by authors named "Thomas Leissing"

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Deficiency of factor-inhibiting HIF creates a tumor-promoting immune microenvironment.
Jingyi Ma, Khatoun Al Moussawi, Hantao Lou, Hok Fung Chan, Yihua Wang, Thomas M Leissing

Proc Natl Acad Sci U S A· March 2024

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Biochemical and Structural Insights into FIH-Catalysed Hydroxylation of Transient Receptor Potential Ankyrin Repeat Domains.
Benjamin G Saward, Thomas M Leissing, Ian J Clifton, Anthony Tumber, Christopher M Timperley

Chembiochem· February 2023

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Factor inhibiting HIF can catalyze two asparaginyl hydroxylations in VNVN motifs of ankyrin fold proteins.
Thomas M Leissing, Adam P Hardy, Hokfung Chan, Yihua Wang, Anthony Tumber

J Biol Chem· June 2022

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Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors.
Jürgen Brem, Tharindi Panduwawala, Jon Ulf Hansen, Joanne Hewitt, Edgars Liepins, Thomas M Leissing

Nat Chem· January 2022

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Structure-Based Design of Selective Fat Mass and Obesity Associated Protein (FTO) Inhibitors.
Shifali Shishodia, Marina Demetriades, Dong Zhang, Nok Yin Tam, Pratheesh Maheswaran, Thomas M Leissing

J Med Chem· November 2021

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X-ray free-electron laser studies reveal correlated motion during isopenicillin synthase catalysis.
Patrick Rabe, Jos J A G Kamps, Kyle D Sutherlin, James D S Linyard, Pierre Aller, Thomas M Leissing

Sci Adv· August 2021

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Structural Investigations of the Inhibition of Escherichia coli AmpC β-Lactamase by Diazabicyclooctanes.
Pauline A Lang, Thomas M Leissing, Malcolm G P Page, Christopher J Schofield, Jürgen Brem

Antimicrob Agents Chemother· January 2021

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Structure driven compound optimization in targeted protein degradation.
Thomas M Leissing, Laura M Luh, Philipp M Cromm

Drug Discov Today Technol· December 2020

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Identification of Small Molecules that Modulate Mutant p53 Condensation.
Clara Lemos, Luise Schulze, Joerg Weiske, Hanna Meyer, Nico Braeuer, Thomas Markus Leissing

iScience· September 2020

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Anaerobic fixed-target serial crystallography.
Patrick Rabe, John H Beale, Agata Butryn, Pierre Aller, Anna Dirr, Thomas M Leissing

IUCrJ· September 2020

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Bicyclic Boronates as Potent Inhibitors of AmpC, the Class C β-Lactamase from .
Pauline A Lang, Anete Parkova, Thomas M Leissing, Karina Calvopiña, Ricky Cain

Biomolecules· June 2020

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A human protein hydroxylase that accepts D-residues.
Hwanho Choi, Adam P Hardy, Thomas M Leissing, Rasheduzzaman Chowdhury, Yu Nakashima

Commun Chem· May 2020

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HIF hydroxylase inhibitors decrease cellular oxygen consumption depending on their selectivity.
Pascale Sulser, Christina Pickel, Julia Günter, Thomas M Leissing, Daniel Crean

FASEB J· February 2020

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CagA-ASPP2 complex mediates loss of cell polarity and favors colonization of human gastric organoids.
Ludovico Buti, Carlos Ruiz-Puig, Dennis Sangberg, Thomas M Leissing, R Camille Brewer

Proc Natl Acad Sci U S A· February 2020

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2-Oxoglutarate-Dependent Oxygenases.
Md Saiful Islam, Thomas M Leissing, Rasheduzzaman Chowdhury, Richard J Hopkinson, Christopher J Schofield

Annu Rev Biochem· June 2018

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Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials.
Tzu-Lan Yeh, Thomas M Leissing, Martine I Abboud, Cyrille C Thinnes, Onur Atasoylu

Chem Sci· November 2017

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Structure-function relationships of human JmjC oxygenases-demethylases versus hydroxylases.
Suzana Markolovic, Thomas M Leissing, Rasheduzzaman Chowdhury, Sarah E Wilkins, Xin Lu

Curr Opin Struct Biol· December 2016

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Trineopentylphosphine: a conformationally flexible ligand for the coupling of sterically demanding substrates in the Buchwald-Hartwig amination and Suzuki-Miyaura reaction.
Steven M Raders, Jane N Moore, Jacquelynn K Parks, Ashley D Miller, Thomas M Leißing

J Org Chem· May 2013

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Nonlinear parabolic equation model for finite-amplitude sound propagation over porous ground layers.
Thomas Leissing, Philippe Jean, Jérôme Defrance, Christian Soize

J Acoust Soc Am· August 2009

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