Publications by authors named "Thomas Sharp"

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Dual-colour super-resolution cryoCLEM in mammalian cells using the fluorescent proteins rsTagRFP and rsEGFP2.
Mart G F Last, Maartje van Klaveren, Lennert Janssen, Nickels Jensen, Isabelle Jansen, Thomas H Sharp

J Struct Biol· December 2025

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Cell-surface RNA forms ternary complex with RNA-binding proteins and heparan sulfate to recruit immune receptors.
Zeshi Li, Bhagyashree S Joshi, Hongbo Yin, Ruud H Wijdeven, Azen Koç, Thomas H Sharp

Mol Cell· December 2025

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Pyroglutamation of cell surface proteins CD47 and TRP1 by glutaminyl cyclase modulates therapeutic antibody binding.
Anneloes van der Plas-van Duijn, Levi M T Winkelman, Claire Lensen, Maaike van Duivendijk, Ian Derksen, Thomas H Sharp

Commun Biol· November 2025

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Renal denervation improves cardiac function and exercise duration in a miniswine model of heart failure with preserved ejection fraction.
David J Lefer, Thomas E Sharp, Amy L Scarborough, Amelia G Haydel, Sanjiv J Shah

Eur J Heart Fail· October 2025

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Hydrogen Sulfide Deficiency and Therapeutic Targeting in Cardiometabolic HFpEF: Evidence for Synergistic Benefit With GLP-1/Glucagon Agonism.
Jake E Doiron, Mahmoud H Elbatreek, Huijing Xia, Xiaoman Yu, Natalie D Gehred, Thomas E Sharp

JACC Basic Transl Sci· October 2025

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Dysregulated Protein -Nitrosylation Promotes Nitrosative Stress and Disease Progression in Heart Failure With Preserved Ejection Fraction.
Zhen Li, Kyle B LaPenna, Natalie D Gehred, Xiaoman Yu, W H Wilson Tang, Thomas E Sharp

Circ Res· October 2025

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Teaching Foundation Doctors How to Manage Tracheostomy Emergencies.
Ashley Wragg, Joe Gleeson-Buddhdev, Thomas Sharp, Reshad Khodabocus

Cureus· October 2025

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Integrated Systems Biology Identifies Disruptions in Mitochondrial Function and Metabolism as Key Contributors to HFpEF.
Andrew A Gibb, Kyle LaPenna, Ryan B Gaspar, Nadina R Latchman, Yinfei Tan, Thomas E Sharp

JACC Basic Transl Sci· September 2025

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Nuclear Protein Aggregates Disrupt RNA Processing and Alter Biomechanics in a Muscle Cell Model of OPMD.
Milad Shademan, Sarah Flannery, Erik Bos, Tom M J Evers, Vahid Sheikhhassani, Thomas H Sharp

Aging Dis· August 2025

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Ultrasound Renal Denervation Attenuates Early Cardiac Remodeling After Acute Myocardial Infarction in a Swine Model of Hypertensions and Dyslipidemia: A Pilot Study.
Thomas E Sharp, Amy L Scarborough, Amelia G Haydel, J Stephen Jenkins, Marloe Prince

Clin Transl Sci· August 2025

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Modulation of immunoglobulin G oligomerization by variable domain glycans: A mechanism to regulate complement activation.
Roxane Biersteker, Leoni Abendstein, Sanne van de Bovenkamp, Hugo J van Dooren, Sebastiaan M W R Hamers, Thomas H Sharp

PNAS Nexus· July 2025

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Polyalanine Expansion in PABPN1 Alters the Structure and Dynamics of Its Nuclear Aggregates in Differentiated Muscle Cells.
Sander D Mallon, Erik Bos, Vahid Sheikhhassani, Milad Shademan, Lenard M Voortman, Thomas H Sharp

FASEB J· June 2025

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Inducing Cancer Cell Killing Using DNA Nanostructure-Mediated Superclustering of Death Receptors.
Göktuğ Aba, Subinuer Abudukelimu, Margot de Winter, Gabriella Collu, Erik Bos, Thomas H Sharp

Nano Lett· April 2025

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Comprehensive echocardiographic protocol for pigs with emphasis on diastolic function: advantages over MRI assessment.
Nadia Martinez Naya, Thomas E Sharp, Manuela G Sgai, Jose M C Capcha, Lina A Shehadeh

Am J Physiol Heart Circ Physiol· March 2025

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Effect of cardiopulmonary resuscitation on perfusion in a porcine model of severe hemorrhagic shock.
Patrick Greiffenstein, Alexander Cavalea, Alison Smith, Thomas Sharp, Olivia Warren

J Trauma Acute Care Surg· February 2025

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Hydrogen Sulfide Deficiency and Therapeutic Targeting in Cardiometabolic HFpEF: Evidence for Synergistic Benefit with GLP-1/Glucagon Agonism.
Jake E Doiron, Mahmoud H Elbatreek, Huijing Xia, Xiaoman Yu, Natalie D Gehred, Thomas E Sharp

bioRxiv· January 2025

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Cardiomyocyte myofilament function in common animal models of heart failure with preserved ejection fraction.
Vivek P Jani, Navid Koleini, Axel J Fenwick, Thomas E Sharp, Traci T Goodchild

J Mol Cell Cardiol· December 2024

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Streamlining segmentation of cryo-electron tomography datasets with Ais.
Mart G F Last, Leoni Abendstein, Lenard M Voortman, Thomas H Sharp

Elife· December 2024

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Alcohol-induced gut microbial reorganization and associated overproduction of phenylacetylglutamine promotes cardiovascular disease.
Zhen Li, Min Gu, Aline Zaparte, Xiaoming Fu, Kala Mahen, Thomas E Sharp

Nat Commun· December 2024

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Dysregulation of Nitrosylation Dynamics Promotes Nitrosative Stress and Contributes to Cardiometabolic Heart Failure with Preserved Ejection Fraction.
Zhen Li, Kyle B LaPenna, Natalie D Gehred, Xiaoman Yu, W H Wilson Tang, Thomas E Sharp

bioRxiv· December 2024

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Thromboxane A2 blockade attenuates ethanol-induced myocardial inflammation: Sipping from the same bottle.
Thomas E Sharp, Thanh Trung Van

Alcohol Clin Exp Res (Hoboken)· October 2024

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Integrated systems biology identifies disruptions in mitochondrial function and metabolism as key contributors to heart failure with preserved ejection fraction (HFpEF).
Andrew A Gibb, Kyle LaPenna, Ryan B Gaspar, Nadina R Latchman, Yinfei Tan, Thomas E Sharp

bioRxiv· October 2024

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Structural basis for surface activation of the classical complement cascade by the short pentraxin C-reactive protein.
Dylan P Noone, Marjolein M E Isendoorn, Sebastiaan M W R Hamers, Mariska E Keizer, Jip Wulffelé, Thomas H Sharp

Proc Natl Acad Sci U S A· September 2024

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Germline variant affecting p53β isoforms predisposes to familial cancer.
Stephanie A Schubert, Dina Ruano, Sebastien M Joruiz, Jordy Stroosma, Nikolina Glavak, Thomas H Sharp

Nat Commun· September 2024

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The source craters of the martian meteorites: Implications for the igneous evolution of Mars.
Christopher D K Herd, Jarret S Hamilton, Erin L Walton, Livio L Tornabene, Anthony Lagain, Thomas G Sharp

Sci Adv· August 2024

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