Publications by authors named "Thorsten Sadowski"

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Hyperpolarized pyruvate to measure the influence of PKM2 activation on glucose metabolism in the healthy kidney.
Lotte Bonde Bertelsen, Esben Søvsø Szocska Hansen, Thorsten Sadowski, Sven Ruf, Christoffer Laustsen

NMR Biomed· November 2021

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Hepatocyte TLR4 triggers inter-hepatocyte Jagged1/Notch signaling to determine NASH-induced fibrosis.
Junjie Yu, Changyu Zhu, Xiaobo Wang, KyeongJin Kim, Alberto Bartolome, Thorsten Sadowski

Sci Transl Med· June 2021

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Cathepsin A contributes to left ventricular remodeling by degrading extracellular superoxide dismutase in mice.
Mathias Hohl, Manuel Mayr, Lisa Lang, Alexander G Nickel, Javier Barallobre-Barreiro, Thorsten Sadowski

J Biol Chem· September 2020

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Characterization of Glycolytic Enzymes and Pyruvate Kinase M2 in Type 1 and 2 Diabetic Nephropathy.
Daniel Gordin, Hetal Shah, Takanori Shinjo, Ronald St-Louis, Weier Qi, Thorsten Sadowski

Diabetes Care· July 2019

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Cathepsin A Mediates Ventricular Remote Remodeling and Atrial Cardiomyopathy in Rats With Ventricular Ischemia/Reperfusion.
Mathias Hohl, Katharina Erb, Lisa Lang, Sven Ruf, Thomas Hübschle, Thorsten Sadowski

JACC Basic Transl Sci· June 2019

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Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction.
Weier Qi, Hillary A Keenan, Qian Li, Atsushi Ishikado, Aimo Kannt, Thorsten Sadowski

Nat Med· June 2017

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Proteomic Profiling of Cardiomyocyte-Specific Cathepsin A Overexpression Links Cathepsin A to the Oxidative Stress Response.
Agnese Petrera, Ursula Kern, Dominik Linz, Alejandro Gomez-Auli, Mathias Hohl, Thorsten Sadowski

J Proteome Res· September 2016

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Cathepsin A mediates susceptibility to atrial tachyarrhythmia and impairment of atrial emptying function in Zucker diabetic fatty rats.
Dominik Linz, Mathias Hohl, Stefan Dhein, Sven Ruf, Jan-Christian Reil, Thorsten Sadowski

Cardiovasc Res· June 2016

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Cathepsin A inhibition attenuates myocardial infarction-induced heart failure on the functional and proteomic levels.
Agnese Petrera, Johann Gassenhuber, Sven Ruf, Deepika Gunasekaran, Jennifer Esser, Thorsten Sadowski

J Transl Med· May 2016

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Tolerability, safety, and pharmacokinetics of the novel cathepsin A inhibitor SAR164653 in healthy subjects.
Joachim Tillner, Anne Lehmann, Tobias Paehler, Zoltan Lukacs, Sven Ruf, Thorsten Sadowski

Clin Pharmacol Drug Dev· January 2016

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Crystal structure of cathepsin A, a novel target for the treatment of cardiovascular diseases.
Herman A Schreuder, Alexander Liesum, Katja Kroll, Britta Böhnisch, Christian Buning, Thorsten Sadowski

Biochem Biophys Res Commun· March 2014

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Inhibition of CatA: an emerging strategy for the treatment of heart failure.
Sven Ruf, Christian Buning, Herman Schreuder, Wolfgang Linz, Thomas Hübschle, Thorsten Sadowski

Future Med Chem· March 2013

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Novel β-amino acid derivatives as inhibitors of cathepsin A.
Sven Ruf, Christian Buning, Herman Schreuder, Georg Horstick, Wolfgang Linz, Thorsten Sadowski

J Med Chem· September 2012

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Long-term severe diabetes only leads to mild cardiac diastolic dysfunction in Zucker diabetic fatty rats.
Anneleen Daniels, Dominik Linz, Marc van Bilsen, Hartmut Rütten, Thorsten Sadowski

Eur J Heart Fail· February 2012

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MMP19 is essential for T cell development and T cell-mediated cutaneous immune responses.
Inken M Beck, René Rückert, Katja Brandt, Markus S Mueller, Thorsten Sadowski

PLoS One· June 2008

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Matrix metalloproteinase-19 expression in keratinocytes is repressed by transcription factors Tst-1 and Skn-1a: implications for keratinocyte differentiation.
Inken M Beck, Matthias Müller, Rolf Mentlein, Thorsten Sadowski, Markus S Mueller

J Invest Dermatol· May 2007

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Matrix metalloproteinase 19 regulates insulin-like growth factor-mediated proliferation, migration, and adhesion in human keratinocytes through proteolysis of insulin-like growth factor binding protein-3.
Thorsten Sadowski, Sebastian Dietrich, Felix Koschinsky, Radislav Sedlacek

Mol Biol Cell· November 2003

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Matrix metalloproteinase-19 expression in normal and diseased skin: dysregulation by epidermal proliferation.
Thorsten Sadowski, Sebastian Dietrich, Matthias Müller, Blanka Havlickova, Michael Schunck

J Invest Dermatol· November 2003

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Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE).
Vance Matthews, Björn Schuster, Stefan Schütze, Ingo Bussmeyer, Andreas Ludwig, Thorsten Sadowski

J Biol Chem· October 2003

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Effects of polysulfated glycosaminoglycan and triamcinolone acetonid on the production of proteinases and their inhibitors by IL-1alpha treated articular chondrocytes.
Thorsten Sadowski, Jürgen Steinmeyer

Biochem Pharmacol· July 2002

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Matrix metalloproteinase-19 is expressed in myeloid cells in an adhesion-dependent manner and associates with the cell surface.
Simon Mauch, Cornelia Kolb, Birgit Kolb, Thorsten Sadowski, Radislav Sedlacek

J Immunol· February 2002

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