Publications by authors named "Tim Clausen"

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Cross-species interactome analysis uncovers a conserved selective autophagy mechanism for protein quality control in plants.
Víctor Sánchez de Medina Hernández, Marintia M Nava-García, Anita Bianchi, Marion Clavel, Ranjith K Papareddy, Tim Clausen

Dev Cell· December 2025

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Structural Basis for Substrate Recruitment and Catalytic Ubiquitin Transfer by the E2/E3 Hybrid Enzyme UBE2O.
Darja Kordic, Thomas L Williams, Luiza Deszcz, Julian F Ehrmann, Renato Arnese, Tim Clausen

J Biol Chem· December 2025

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ClpC1 Modulating Ohmyungsamycin A and Ecumicin Natural Product Analogues are Potent Antimycobacterials.
Paige M E Hawkins, Max J Bedding, David M Hoi, Isabel K Barter, Chen-Yi Cheung, Tim Clausen

ACS Infect Dis· November 2025

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A split-site E3 ligase mechanism enables ZNFX1 to ubiquitinate and cluster single-stranded RNA into ubiquitin-coated nucleoprotein particles.
Daniel B Grabarczyk, Eric J Aird, Vanessa Reznikow, Paul C Kirchgatterer, Julian F Ehrmann, Tim Clausen

Cell· October 2025

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Architecture of the UBR4 complex, a giant E4 ligase central to eukaryotic protein quality control.
Daniel B Grabarczyk, Julian F Ehrmann, Paul Murphy, Woo Seok Yang, Robert Kurzbauer, Tim Clausen

Science· August 2025

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ATP functions as a pathogen-associated molecular pattern to activate the E3 ubiquitin ligase RNF213.
Juraj Ahel, Arda Balci, Victoria Faas, Daniel B Grabarczyk, Roosa Harmo, Tim Clausen

Nat Commun· May 2025

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TRIM52 maintains cellular fitness and is under tight proteolytic control by multiple giant E3 ligases.
Alexandra Shulkina, Kathrin Hacker, Julian F Ehrmann, Valentina Budroni, Ariane Mandlbauer, Tim Clausen

Nat Commun· April 2025

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Protein waste turned into antibiotics as a defence strategy of human cells.
Tim Clausen

Nature· March 2025

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Convergence of orphan quality control pathways at a ubiquitin chain-elongating ligase.
Sara Carrillo Roas, Yuichi Yagita, Paul Murphy, Robert Kurzbauer, Tim Clausen

Mol Cell· February 2025

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Author Correction: PARP14 and PARP9/DTX3L regulate interferon-induced ADP-ribosylation.
Pulak Kar, Chatrin Chatrin, Nina Đukić, Osamu Suyari, Marion Schuller, Tim Clausen

EMBO J· November 2024

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PARP14 and PARP9/DTX3L regulate interferon-induced ADP-ribosylation.
Pulak Kar, Chatrin Chatrin, Nina Đukić, Osamu Suyari, Marion Schuller, Tim Clausen

EMBO J· July 2024

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Rational correction of pathogenic conformational defects in HTRA1.
Nathalie Beaufort, Linda Ingendahl, Melisa Merdanovic, Andree Schmidt, David Podlesainski, Tim Clausen

Nat Commun· July 2024

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UNC-45 assisted myosin folding depends on a conserved FXHY motif implicated in Freeman Sheldon Syndrome.
Antonia Vogel, Renato Arnese, Ricardo M Gudino Carrillo, Daria Sehr, Luiza Deszcz, Tim Clausen

Nat Commun· July 2024

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Homo-BacPROTAC-induced degradation of ClpC1 as a strategy against drug-resistant mycobacteria.
Lukas Junk, Volker M Schmiedel, Somraj Guha, Katharina Fischel, Peter Greb, Tim Clausen

Nat Commun· March 2024

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Shuffled ATG8 interacting motifs form an ancestral bridge between UFMylation and autophagy.
Lorenzo Picchianti, Víctor Sánchez de Medina Hernández, Ni Zhan, Nicholas At Irwin, Roan Groh, Tim Clausen

EMBO J· May 2023

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Clp-targeting BacPROTACs impair mycobacterial proteostasis and survival.
David M Hoi, Sabryna Junker, Lukas Junk, Kristin Schwechel, Katharina Fischel, Tim Clausen

Cell· May 2023

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Structural basis for regulation of apoptosis and autophagy by the BIRC6/SMAC complex.
Julian F Ehrmann, Daniel B Grabarczyk, Maria Heinke, Luiza Deszcz, Robert Kurzbauer, Tim Clausen

Science· March 2023

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HUWE1 controls tristetraprolin proteasomal degradation by regulating its phosphorylation.
Sara Scinicariello, Adrian Soderholm, Markus Schäfer, Alexandra Shulkina, Irene Schwartz, Tim Clausen

Elife· March 2023

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Moyamoya disease: diagnosis and interventions.
Masafumi Ihara, Yumi Yamamoto, Yorito Hattori, Wanyang Liu, Hatasu Kobayashi, Tim Clausen

Lancet Neurol· August 2022

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BacPROTACs mediate targeted protein degradation in bacteria.
Francesca E Morreale, Stefan Kleine, Julia Leodolter, Sabryna Junker, David M Hoi, Tim Clausen

Cell· June 2022

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Targeted protein degradation: from small molecules to complex organelles-a Keystone Symposia report.
Jennifer Cable, Eilika Weber-Ban, Tim Clausen, Kylie J Walters, Michal Sharon

Ann N Y Acad Sci· April 2022

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An allosteric HTRA1-calpain 2 complex with restricted activation profile.
Juliana Rey, Maike Breiden, Vanda Lux, Anika Bluemke, Maike Steindel, Tim Clausen

Proc Natl Acad Sci U S A· April 2022

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Potent Bactericidal Antimycobacterials Targeting the Chaperone ClpC1 Based on the Depsipeptide Natural Products Ecumicin and Ohmyungsamycin A.
Paige M E Hawkins, David M Hoi, Chen-Yi Cheung, Trixie Wang, Diana Quan, Tim Clausen

J Med Chem· March 2022

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McsB forms a gated kinase chamber to mark aberrant bacterial proteins for degradation.
Bence Hajdusits, Marcin J Suskiewicz, Nikolas Hundt, Anton Meinhart, Robert Kurzbauer, Tim Clausen

Elife· July 2021

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APPARILLO: a fully operational and autonomous staring system for LEO debris detection.
Paul Wagner, Tim Clausen

CEAS Space J· July 2021

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