Publications by authors named "Tim D D Somerville"

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Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer.
Leslie Duplaquet, Kevin So, Alexander W Ying, Shreoshi Pal Choudhuri, Xinyue Li, Tim D D Somerville

Cancer Cell· August 2024

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Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer.
Leslie Duplaquet, Kevin So, Alexander W Ying, Xinyue Li, Yixiang Li, Tim D D Somerville

bioRxiv· January 2024

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p73 activates transcriptional signatures of basal lineage identity and ciliogenesis in pancreatic ductal adenocarcinoma.
Stella K Hur, Tim D D Somerville, Xiaoli S Wu, Diogo Maia-Silva, Osama E Demerdash

bioRxiv· April 2023

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BRD8 maintains glioblastoma by epigenetic reprogramming of the p53 network.
Xueqin Sun, Olaf Klingbeil, Bin Lu, Caizhi Wu, Carlos Ballon, Tim D D Somerville

Nature· January 2023

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Intraductal Transplantation Models of Human Pancreatic Ductal Adenocarcinoma Reveal Progressive Transition of Molecular Subtypes.
Koji Miyabayashi, Lindsey A Baker, Astrid Deschênes, Benno Traub, Giuseppina Caligiuri, Tim D D Somerville

Cancer Discov· October 2020

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SOAT1 promotes mevalonate pathway dependency in pancreatic cancer.
Tobiloba E Oni, Giulia Biffi, Lindsey A Baker, Yuan Hao, Claudia Tonelli, Tim D D Somerville

J Exp Med· September 2020

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ZBED2 is an antagonist of interferon regulatory factor 1 and modifies cell identity in pancreatic cancer.
Tim D D Somerville, Yali Xu, Xiaoli S Wu, Diogo Maia-Silva, Stella K Hur

Proc Natl Acad Sci U S A· May 2020

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A Transcription Factor Addiction in Leukemia Imposed by the MLL Promoter Sequence.
Bin Lu, Olaf Klingbeil, Yusuke Tarumoto, Tim D D Somerville, Yu-Han Huang

Cancer Cell· December 2018

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TP63-Mediated Enhancer Reprogramming Drives the Squamous Subtype of Pancreatic Ductal Adenocarcinoma.
Tim D D Somerville, Yali Xu, Koji Miyabayashi, Hervé Tiriac, Cristian R Cleary

Cell Rep· November 2018

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Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer.
Hervé Tiriac, Pascal Belleau, Dannielle D Engle, Dennis Plenker, Astrid Deschênes, Tim D D Somerville

Cancer Discov· September 2018

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POU2F3 is a master regulator of a tuft cell-like variant of small cell lung cancer.
Yu-Han Huang, Olaf Klingbeil, Xue-Yan He, Xiaoli S Wu, Gayatri Arun, Tim D D Somerville

Genes Dev· July 2018

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LKB1, Salt-Inducible Kinases, and MEF2C Are Linked Dependencies in Acute Myeloid Leukemia.
Yusuke Tarumoto, Bin Lu, Tim D D Somerville, Yu-Han Huang, Joseph P Milazzo

Mol Cell· March 2018

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A TFIID-SAGA Perturbation that Targets MYB and Suppresses Acute Myeloid Leukemia.
Yali Xu, Joseph P Milazzo, Tim D D Somerville, Yusuke Tarumoto, Yu-Han Huang

Cancer Cell· January 2018

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Derepression of the Iroquois Homeodomain Transcription Factor Gene IRX3 Confers Differentiation Block in Acute Leukemia.
Tim D D Somerville, Fabrizio Simeoni, John A Chadwick, Emma L Williams, Gary J Spencer

Cell Rep· January 2018

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Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis.
Jae-Seok Roe, Chang-Il Hwang, Tim D D Somerville, Joseph P Milazzo, Eun Jung Lee

Cell· August 2017

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Modeling the Epigenetic Chain Reaction Downstream of DNMT3A(R882H).
Tim D D Somerville, Christopher R Vakoc

Cancer Cell· July 2016

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Tissue-inappropriate derepression of FOXC1 is frequent and functional in human acute myeloid leukemia.
Tim D D Somerville, Tim C P Somervaille

Mol Cell Oncol· March 2016

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Frequent Derepression of the Mesenchymal Transcription Factor Gene FOXC1 in Acute Myeloid Leukemia.
Tim D D Somerville, Daniel H Wiseman, Gary J Spencer, Xu Huang, James T Lynch

Cancer Cell· September 2015

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A targeted knockdown screen of genes coding for phosphoinositide modulators identifies PIP4K2A as required for acute myeloid leukemia cell proliferation and survival.
Julian G Jude, Gary J Spencer, Xu Huang, Tim D D Somerville, David R Jones

Oncogene· March 2015

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