Publications by authors named "Tim Demuth"

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Phase I Dose-Escalation and -Expansion Study of the BRAF Inhibitor Encorafenib (LGX818) in Metastatic -Mutant Melanoma.
Jean-Pierre Delord, Caroline Robert, Marta Nyakas, Grant A McArthur, Ragini Kudchakar, Tim Demuth

Clin Cancer Res· September 2017

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A Phase Ib Dose-Escalation Study of Encorafenib and Cetuximab with or without Alpelisib in Metastatic -Mutant Colorectal Cancer.
Robin M J M van Geel, Josep Tabernero, Elena Elez, Johanna C Bendell, Anna Spreafico, Tim Demuth

Cancer Discov· June 2017

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Phase I Study Evaluating WEE1 Inhibitor AZD1775 As Monotherapy and in Combination With Gemcitabine, Cisplatin, or Carboplatin in Patients With Advanced Solid Tumors.
Suzanne Leijen, Robin M J M van Geel, Anna C Pavlick, Raoul Tibes, Lee Rosen, Tim Demuth

J Clin Oncol· December 2016

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A phase II study of Givinostat in combination with hydroxycarbamide in patients with polycythaemia vera unresponsive to hydroxycarbamide monotherapy.
Guido Finazzi, Alessandro M Vannucchi, Vincenzo Martinelli, Marco Ruggeri, Francesco Nobile, Tim Demuth

Br J Haematol· June 2013

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Combination therapy using Notch and Akt inhibitors is effective for suppressing invasion but not proliferation in glioma cells.
Rihua Jin, Mitsutoshi Nakada, Lei Teng, Takuya Furuta, Hemragul Sabit, Tim Demuth

Neurosci Lett· February 2013

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Phase I pharmacologic and pharmacodynamic study of the gamma secretase (Notch) inhibitor MK-0752 in adult patients with advanced solid tumors.
Ian Krop, Tim Demuth, Tina Guthrie, Patrick Y Wen, Warren P Mason

J Clin Oncol· July 2012

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RNAi screening of the kinome with cytarabine in leukemias.
Raoul Tibes, James M Bogenberger, Leena Chaudhuri, R Tanner Hagelstrom, Donald Chow, Tim Demuth

Blood· March 2012

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Gamma secretase inhibition promotes hypoxic necrosis in mouse pancreatic ductal adenocarcinoma.
Natalie Cook, Kristopher K Frese, Tashinga E Bapiro, Michael A Jacobetz, Aarthi Gopinathan, Tim Demuth

J Exp Med· March 2012

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Targeting radiation-induced G(2) checkpoint activation with the Wee-1 inhibitor MK-1775 in glioblastoma cell lines.
Bhaswati Sarcar, Soumen Kahali, Antony H Prabhu, Stuart D Shumway, Yang Xu, Tim Demuth

Mol Cancer Ther· December 2011

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Phase I trial of MK-0752 in children with refractory CNS malignancies: a pediatric brain tumor consortium study.
Maryam Fouladi, Clinton F Stewart, James Olson, Lars M Wagner, Arzu Onar-Thomas, Tim Demuth

J Clin Oncol· September 2011

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MK-1775, a potent Wee1 inhibitor, synergizes with gemcitabine to achieve tumor regressions, selectively in p53-deficient pancreatic cancer xenografts.
N V Rajeshkumar, Elizabeth De Oliveira, Niki Ottenhof, James Watters, David Brooks, Tim Demuth

Clin Cancer Res· May 2011

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The phosphorylation of ephrin-B2 ligand promotes glioma cell migration and invasion.
Mitsutoshi Nakada, Eric M Anderson, Tim Demuth, Satoko Nakada, Linsey B Reavie

Int J Cancer· March 2010

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De novo discovery of a gamma-secretase inhibitor response signature using a novel in vivo breast tumor model.
James W Watters, Chun Cheng, Pradip K Majumder, Ruojie Wang, Sireesha Yalavarthi, Tim Demuth

Cancer Res· December 2009

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Autotaxin: a secreted autocrine/paracrine factor that promotes glioma invasion.
Dominique B Hoelzinger, Mitsutoshi Nakada, Tim Demuth, Tyler Rosensteel, Linsey B Reavie

J Neurooncol· February 2008

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Glioma cells on the run - the migratory transcriptome of 10 human glioma cell lines.
Tim Demuth, Jessica L Rennert, Dominique B Hoelzinger, Linsey B Reavie, Mitsutoshi Nakada

BMC Genomics· January 2008

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Autocrine factors that sustain glioma invasion and paracrine biology in the brain microenvironment.
Dominique B Hoelzinger, Tim Demuth, Michael E Berens

J Natl Cancer Inst· November 2007

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Estimating the cell density and invasive radius of three-dimensional glioblastoma tumor spheroids grown in vitro.
Andrew M Stein, Michal O Nowicki, Tim Demuth, Michael E Berens, Sean E Lawler

Appl Opt· August 2007

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MAP-ing glioma invasion: mitogen-activated protein kinase kinase 3 and p38 drive glioma invasion and progression and predict patient survival.
Tim Demuth, Linsey B Reavie, Jessica L Rennert, Mitsutoshi Nakada, Satoko Nakada

Mol Cancer Ther· April 2007

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A mathematical model of glioblastoma tumor spheroid invasion in a three-dimensional in vitro experiment.
Andrew M Stein, Tim Demuth, David Mobley, Michael Berens, Leonard M Sander

Biophys J· January 2007

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Correlating velocity patterns with spatial dynamics in glioma cell migration.
Thomas S Deisboeck, Tim Demuth, Yuri Mansury

Acta Biotheor· April 2006

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Molecular mechanisms of glioma cell migration and invasion.
Tim Demuth, Michael E Berens

J Neurooncol· November 2004

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Migrating glioma cells activate the PI3-K pathway and display decreased susceptibility to apoptosis.
Anna M Joy, Christian E Beaudry, Nhan L Tran, Francisco A Ponce, David R Holz, Tim Demuth

J Cell Sci· November 2003

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