Publications by authors named "Tim Failes"

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FDA-approved disulfiram as a novel treatment for aggressive leukemia.
Mawar Karsa, Lin Xiao, Emma Ronca, Angelika Bongers, Dayna Spurling, Tim W Failes

J Mol Med (Berl)· April 2024

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Combination drug screen targeting glioblastoma core vulnerabilities reveals pharmacological synergisms.
Jérémy Ariey-Bonnet, Raphael Berges, Marie-Pierre Montero, Baptiste Mouysset, Patricia Piris, Tim W Failes

EBioMedicine· September 2023

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In vitro and in vivo drug screens of tumor cells identify novel therapies for high-risk child cancer.
Loretta M S Lau, Chelsea Mayoh, Jinhan Xie, Paulette Barahona, Karen L MacKenzie, Tim W Failes

EMBO Mol Med· April 2022

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Combination efficacy of ruxolitinib with standard-of-care drugs in CRLF2-rearranged Ph-like acute lymphoblastic leukemia.
Julia W Bӧhm, Keith C S Sia, Connor Jones, Kathryn Evans, Anna Mariana, Tim Failes

Leukemia· November 2021

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Exploiting the reactive oxygen species imbalance in high-risk paediatric acute lymphoblastic leukaemia through auranofin.
Mawar Karsa, Angelika Kosciolek, Angelika Bongers, Anna Mariana, Tim Failes

Br J Cancer· July 2021

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High-Content Imaging of Unbiased Chemical Perturbations Reveals that the Phenotypic Plasticity of the Actin Cytoskeleton Is Constrained.
Nicole S Bryce, Tim W Failes, Justine R Stehn, Karen Baker, Stefan Zahler

Cell Syst· November 2019

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Integration of genomics, high throughput drug screening, and personalized xenograft models as a novel precision medicine paradigm for high risk pediatric cancer.
Maria Tsoli, Carol Wadham, Mark Pinese, Tim Failes, Swapna Joshi

Cancer Biol Ther· September 2019

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A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction.
Klaartje Somers, Victoria W Wen, Shiloh M C Middlemiss, Brenna Osborne, Helen Forgham, Tim W Failes

Oncogene· May 2019

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Identification of new MRP4 inhibitors from a library of FDA approved drugs using a high-throughput bioluminescence screen.
Leanna Cheung, Denise M T Yu, Zillan Neiron, Tim W Failes, Greg M Arndt

Biochem Pharmacol· February 2015

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High-throughput screening of human leukemia xenografts to identify dexamethasone sensitizers.
Cara E Toscan, Tim Failes, Greg M Arndt, Richard B Lock

J Biomol Screen· December 2014

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