Publications by authors named "Tim Guilliams"

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A novel combination treatment for fragile X syndrome predicted using computational methods.
Wayne Chadwick, Ivan Angulo-Herrera, Patricia Cogram, Robert J M Deacon, Daniel J Mason, Tim Guilliams

Brain Commun· January 2024

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The use or generation of biomedical data and existing medicines to discover and establish new treatments for patients with rare diseases - recommendations of the IRDiRC Data Mining and Repurposing Task Force.
Noel T Southall, Madhusudan Natarajan, Lilian Pek Lian Lau, Anneliene Hechtelt Jonker, Benoît Deprez, Tim Guilliams

Orphanet J Rare Dis· October 2019

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Understanding and predicting disease relationships through similarity fusion.
Erin Oerton, Ian Roberts, Patrick S H Lewis, Tim Guilliams, Andreas Bender

Bioinformatics· April 2019

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Repurposing available drugs for neurodevelopmental disorders: The fragile X experience.
Michael R Tranfaglia, Clare Thibodeaux, Daniel J Mason, David Brown, Ian Roberts, Tim Guilliams

Neuropharmacology· March 2019

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Drug repurposing: progress, challenges and recommendations.
Sudeep Pushpakom, Francesco Iorio, Patrick A Eyers, K Jane Escott, Shirley Hopper, Tim Guilliams

Nat Rev Drug Discov· January 2019

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Exploring the role of post-translational modifications in regulating α-synuclein interactions by studying the effects of phosphorylation on nanobody binding.
Farah El Turk, Erwin De Genst, Tim Guilliams, Bruno Fauvet, Mirva Hejjaoui

Protein Sci· July 2018

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The antidepressant tianeptine reverts synaptic AMPA receptor defects caused by deficiency of CDKL5.
Marco Tramarin, Laura Rusconi, Lara Pizzamiglio, Isabella Barbiero, Diana Peroni, Tim Guilliams

Hum Mol Genet· June 2018

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Nanobodies raised against monomeric É‘-synuclein inhibit fibril formation and destabilize toxic oligomeric species.
Marija Iljina, Liu Hong, Mathew H Horrocks, Marthe H Ludtmann, Minee L Choi, Tim Guilliams

BMC Biol· July 2017

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Structural Effects of Two Camelid Nanobodies Directed to Distinct C-Terminal Epitopes on α-Synuclein.
Farah El-Turk, Francisco N Newby, Erwin De Genst, Tim Guilliams, Tara Sprules

Biochemistry· June 2016

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Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation.
Serene W Chen, Srdja Drakulic, Emma Deas, Myriam Ouberai, Francesco A Aprile, Tim Guilliams

Proc Natl Acad Sci U S A· April 2015

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Identifying the science and technology dimensions of emerging public policy issues through horizon scanning.
Miles Parker, Andrew Acland, Harry J Armstrong, Jim R Bellingham, Jessica Bland, Tim T Guilliams

PLoS One· January 2015

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Preconditioning of microglia by α-synuclein strongly affects the response induced by toll-like receptor (TLR) stimulation.
Cintia Roodveldt, Adahir Labrador-Garrido, Elena Gonzalez-Rey, Christian C Lachaud, Tim Guilliams

PLoS One· September 2014

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Nanobodies raised against monomeric α-synuclein distinguish between fibrils at different maturation stages.
Tim Guilliams, Farah El-Turk, Alexander K Buell, Elizabeth M O'Day, Francesco A Aprile

J Mol Biol· July 2013

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α-Synuclein senses lipid packing defects and induces lateral expansion of lipids leading to membrane remodeling.
Myriam M Ouberai, Juan Wang, Marcus J Swann, Celine Galvagnion, Tim Guilliams

J Biol Chem· July 2013

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Structure and properties of a complex of α-synuclein and a single-domain camelid antibody.
Erwin J De Genst, Tim Guilliams, Joke Wellens, Elizabeth M O'Day, Christopher A Waudby

J Mol Biol· September 2010

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