Publications by authors named "Tim M Townes"

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A novel mouse model of hemoglobin SC disease reveals mechanisms underlying beneficial effects of hydroxyurea.
Tahereh Setayesh, Mengna Chi, Zachery Oestreicher, Masahide Sakabe, Katie Seu, Tim M Townes

Blood· July 2025

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Epigenetic switch reshapes epithelial progenitor cell signatures and drives inflammatory pathogenesis in hidradenitis suppurativa.
Lin Jin, Yunjia Chen, Suhail Muzaffar, Chao Li, Carlos A Mier-Aguilar, Tim M Townes

Proc Natl Acad Sci U S A· December 2023

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Prime editing-mediated correction of the CFTR W1282X mutation in iPSCs and derived airway epithelial cells.
Chao Li, Zhong Liu, Justin Anderson, Zhongyu Liu, Liping Tang, Tim M Townes

PLoS One· December 2023

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Validation of single-gene noninvasive prenatal testing for sickle cell disease.
Erik R Westin, David S Tsao, Oguzhan Atay, Brian P Landry, Patrick P Ye, Tim M Townes

Am J Hematol· July 2022

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A "Shot in the Arm" for Sickle Cell Disease.
Tim M Townes

Mol Ther· February 2021

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A novel therapeutic strategy for β-thalassemia.
Tim M Townes

Blood· May 2019

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Exogenous sickle erythrocytes combined with vascular disruption trigger disseminated tumor vaso-occlusion and lung tumor regression.
Chiao-Wang Sun, Li-Chen Wu, Mamta Wankhede, Dezhi Wang, Jutta Thoerner, Tim M Townes

JCI Insight· April 2019

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Human Leukocyte Antigen Class I and II Knockout Human Induced Pluripotent Stem Cell-Derived Cells: Universal Donor for Cell Therapy.
Saidulu Mattapally, Kevin M Pawlik, Vladimir G Fast, Esther Zumaquero, Frances E Lund, Tim M Townes

J Am Heart Assoc· December 2018

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Defining the epigenetic status of blood cells using a cyanine-based fluorescent probe for PRMT1.
Hairui Su, Chiao-Wang Sun, Szu-Mam Liu, Xin He, Hao Hu, Tim M Townes

Blood Adv· November 2018

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Bone Marrow Transplantation after Nonmyeloablative Treosulfan Conditioning Is Curative in a Murine Model of Sickle Cell Disease.
Divya Devadasan, Chiao-Wang Sun, Erik R Westin, Li-Chen Wu, Kevin M Pawlik, Tim M Townes

Biol Blood Marrow Transplant· August 2018

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Elevated p53 Activities Restrict Differentiation Potential of MicroRNA-Deficient Pluripotent Stem Cells.
Zhong Liu, Cheng Zhang, Maria Skamagki, Alireza Khodadadi-Jamayran, Wei Zhang, Tim M Townes

Stem Cell Reports· November 2017

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Long-Term Endothelin-A Receptor Antagonism Provides Robust Renal Protection in Humanized Sickle Cell Disease Mice.
Malgorzata Kasztan, Brandon M Fox, Joshua S Speed, Carmen De Miguel, Eman Y Gohar, Tim M Townes

J Am Soc Nephrol· August 2017

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Induced Pluripotent Stem Cell-Derived Endothelial Cells Overexpressing Interleukin-8 Receptors A/B and/or C-C Chemokine Receptors 2/5 Inhibit Vascular Injury Response.
Samantha Giordano, Xiangmin Zhao, Yiu-Fai Chen, Silvio H Litovsky, Fadi G Hage, Tim M Townes

Stem Cells Transl Med· April 2017

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Leukocyte iNOS is required for inflammation and pathological remodeling in ischemic heart failure.
Justin R Kingery, Tariq Hamid, Robert K Lewis, Mohamed Ameen Ismahil, Shyam S Bansal, Tim M Townes

Basic Res Cardiol· March 2017

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Reprogramming by De-bookmarking the Somatic Transcriptional Program through Targeting of BET Bromodomains.
Zhicheng Shao, Chunping Yao, Alireza Khodadadi-Jamayran, Weihua Xu, Tim M Townes

Cell Rep· September 2016

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Sickle Cells Abolish Melanoma Tumorigenesis in Hemoglobin SS Knockin Mice and Augment the Tumoricidal Effect of Oncolytic Virus In Vivo.
Chiang Wang Sun, Candice Willmon, Li-Chen Wu, Peter Knopick, Jutta Thoerner, Tim M Townes

Front Oncol· July 2016

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Novel HDAd/EBV Reprogramming Vector and Highly Efficient Ad/CRISPR-Cas Sickle Cell Disease Gene Correction.
Chao Li, Lei Ding, Chiao-Wang Sun, Li-Chen Wu, Dewang Zhou, Tim M Townes

Sci Rep· July 2016

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The AS-RBM15 lncRNA enhances RBM15 protein translation during megakaryocyte differentiation.
Ngoc-Tung Tran, Hairui Su, Alireza Khodadadi-Jamayran, Shan Lin, Li Zhang, Tim M Townes

EMBO Rep· June 2016

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The acetyllysine reader BRD3R promotes human nuclear reprogramming and regulates mitosis.
Zhicheng Shao, Ruowen Zhang, Alireza Khodadadi-Jamayran, Bo Chen, Michael R Crowley, Tim M Townes

Nat Commun· March 2016

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Endothelin-1 contributes to the progression of renal injury in sickle cell disease via reactive oxygen species.
J Brett Heimlich, Joshua S Speed, Paul M O'Connor, Jennifer S Pollock, Tim M Townes

Br J Pharmacol· January 2016

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The histone H2A deubiquitinase Usp16 regulates hematopoiesis and hematopoietic stem cell function.
Yue Gu, Amanda E Jones, Wei Yang, Shanrun Liu, Qian Dai, Tim M Townes

Proc Natl Acad Sci U S A· January 2016

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Modeling Human Severe Combined Immunodeficiency and Correction by CRISPR/Cas9-Enhanced Gene Targeting.
Chia-Wei Chang, Yi-Shin Lai, Erik Westin, Alireza Khodadadi-Jamayran, Kevin M Pawlik, Tim M Townes

Cell Rep· September 2015

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Broad T-cell receptor repertoire in T-lymphocytes derived from human induced pluripotent stem cells.
Chia-Wei Chang, Yi-Shin Lai, Lawrence S Lamb, Tim M Townes

PLoS One· January 2015

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The histone H2A deubiquitinase Usp16 regulates embryonic stem cell gene expression and lineage commitment.
Wei Yang, Yun-Hwa Lee, Amanda E Jones, Jessica L Woolnough, Dewang Zhou, Tim M Townes

Nat Commun· May 2014

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USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing.
Zhuo Zhang, Amanda Jones, Heui-Yun Joo, Dewang Zhou, Ying Cao, Tim M Townes

Genes Dev· July 2013

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