Publications by authors named "Tim Moors"

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C-terminus-dependent detection of lysosomal alpha-synuclein in nigral Parkinson's disease human brain neurons.
Martino L Morella, Bana Al Khayrat, Tim E Moors, Lisanne In't Veld, Irene Frigerio

Mol Neurodegener· October 2025

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Stearoyl-CoA desaturase inhibition normalizes brain lipid saturation, α-synuclein homeostasis, and motor function in mutant Gba1-Parkinson mice.
Silke Nuber, Harrison Hsiang, Esra'a Keewan, Tim E Moors, Sydney J Reitz

JCI Insight· July 2025

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Acute lipid droplet accumulation induced by the inhibition of the phospholipase DDHD2 does not affect the level, solubility, or phosphoserine-129 status of α-synuclein.
Magdalena M Bolsinger, Tim E Moors, Lisa Brontesi, Silke Nuber, Ulf Dettmer

Metab Brain Dis· January 2025

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Altered TFEB subcellular localization in nigral neurons of subjects with incidental, sporadic and GBA-related Lewy body diseases.
Tim E Moors, Martino L Morella, Cesc Bertran-Cobo, Hanneke Geut, Vinod Udayar

Acta Neuropathol· April 2024

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Author Correction: Generation of G51D and 3D mice reveals decreased α-synuclein tetramer-monomer ratios promote Parkinson's disease phenotypes.
Silke Nuber, Xiaoqun Zhang, Thomas D McCaffery, Tim E Moors, Marie-Alexandre Adom

NPJ Parkinsons Dis· March 2024

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Generation of G51D and 3D mice reveals decreased α-synuclein tetramer-monomer ratios promote Parkinson's disease phenotypes.
Silke Nuber, Xiaoqun Zhang, Thomas D McCaffery, Tim E Moors, Marie-Alexandre Adom

NPJ Parkinsons Dis· February 2024

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Defining a Lewy Body: Running Up the Hill of Shifting Definitions and Evolving Concepts.
Tim E Moors, Dragomir Milovanovic

J Parkinsons Dis· January 2024

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Increased palmitoylation improves estrogen receptor alpha-dependent hippocampal synaptic deficits in a mouse model of synucleinopathy.
Tim E Moors, Shaomin Li, Thomas D McCaffery, Gary P H Ho, Pascal A Bechade

Sci Adv· November 2023

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Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity.
Nagendran Ramalingam, Shan-Xue Jin, Tim E Moors, Luis Fonseca-Ornelas, Kazuma Shimanaka

NPJ Parkinsons Dis· January 2023

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Multi-platform quantitation of alpha-synuclein human brain proteoforms suggests disease-specific biochemical profiles of synucleinopathies.
Tim E Moors, Daniel Mona, Stefan Luehe, Gonzalo Duran-Pacheco, Liz Spycher

Acta Neuropathol Commun· June 2022

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The subcellular arrangement of alpha-synuclein proteoforms in the Parkinson's disease brain as revealed by multicolor STED microscopy.
Tim E Moors, Christina A Maat, Daniel Niedieker, Daniel Mona, Dennis Petersen

Acta Neuropathol· September 2021

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Wild-type GBA1 increases the α-synuclein tetramer-monomer ratio, reduces lipid-rich aggregates, and attenuates motor and cognitive deficits in mice.
Kelly E Glajch, Tim E Moors, Yi Chen, Pascal A Bechade, Alice Y Nam

Proc Natl Acad Sci U S A· August 2021

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Alterations in Sub-Axonal Architecture Between Normal Aging and Parkinson's Diseased Human Brains Using Label-Free Cryogenic X-ray Nanotomography.
Hung Tri Tran, Esther H R Tsai, Amanda J Lewis, Tim Moors, J G J M Bol

Front Neurosci· November 2020

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Lewy pathology in Parkinson's disease consists of crowded organelles and lipid membranes.
Sarah H Shahmoradian, Amanda J Lewis, Christel Genoud, Jürgen Hench, Tim E Moors

Nat Neurosci· July 2019

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Characterization of Brain Lysosomal Activities in GBA-Related and Sporadic Parkinson's Disease and Dementia with Lewy Bodies.
Tim E Moors, Silvia Paciotti, Angela Ingrassia, Marialuisa Quadri, Guido Breedveld

Mol Neurobiol· February 2019

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Path mediation analysis reveals GBA impacts Lewy body disease status by increasing α-synuclein levels.
Anna Lisa Gündner, Gonzalo Duran-Pacheco, Silke Zimmermann, Iris Ruf, Tim Moors

Neurobiol Dis· January 2019

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Origin of α-mannosidase activity in CSF.
Anna Tasegian, Silvia Paciotti, Maria Rachele Ceccarini, Michela Codini, Tim Moors

Int J Biochem Cell Biol· June 2017

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Therapeutic potential of autophagy-enhancing agents in Parkinson's disease.
Tim E Moors, Jeroen J M Hoozemans, Angela Ingrassia, Tommaso Beccari, Lucilla Parnetti

Mol Neurodegener· January 2017

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Lysosomal Dysfunction and α-Synuclein Aggregation in Parkinson's Disease: Diagnostic Links.
Tim Moors, Silvia Paciotti, Davide Chiasserini, Paolo Calabresi, Lucilla Parnetti

Mov Disord· June 2016

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Microglial phenotypes and toll-like receptor 2 in the substantia nigra and hippocampus of incidental Lewy body disease cases and Parkinson's disease patients.
Karlijn J Doorn, Tim Moors, Benjamin Drukarch, Wilma Dj van de Berg, Paul J Lucassen

Acta Neuropathol Commun· August 2014

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