Publications by authors named "Tim Thomas"

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Functional Mapping of Epigenomic Regulators Uncovers Coordinated Tumor Suppression by the HBO1 and MLL1 Complexes.
Yuning J Tang, Haiqing Xu, Nicholas W Hughes, Paloma Ruiz, Samuel H Kim, Tim Thomas

Cancer Discov· December 2025

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Relative importance of the anti-apoptotic versus apoptosis-unrelated functions of MCL-1 in vivo.
Kerstin Brinkmann, Kate McArthur, Shezlie Malelang, Leonie Gibson, Annli Tee, Tim Thomas

Science· September 2025

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Loss of KAT6B causes premature ossification and promotes osteoblast differentiation during development.
Maria I Bergamasco, Jacqueline M Ogier, Alexandra L Garnham, Lachlan Whitehead, Kelly Rogers, Tim Thomas

Dev Biol· April 2025

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KAT6B overexpression in mice causes aggression, anxiety, and epilepsy.
Maria I Bergamasco, Ezgi Ozturk, Pablo M Casillas-Espinosa, Alexandra L Garnham, Waruni Abeysekera, Tim Thomas

iScience· March 2025

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KAT6B is required for histone 3 lysine 9 acetylation and SOX gene expression in the developing brain.
Maria I Bergamasco, Waruni Abeysekera, Alexandra L Garnham, Yifang Hu, Connie Sn Li-Wai-Suen, Tim Thomas

Life Sci Alliance· February 2025

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KAT6B overexpression rescues embryonic lethality in homozygous null KAT6A mice restoring vitality and normal lifespan.
Maria I Bergamasco, Yuqing Yang, Alexandra L Garnham, Bilal N Sheikh, Gordon K Smyth, Tim Thomas

Nat Commun· February 2025

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Loss of PHF6 causes spontaneous seizures, enlarged brain ventricles and altered transcription in the cortex of a mouse model of the Börjeson-Forssman-Lehmann intellectual disability syndrome.
Helen M McRae, Melody P Y Leong, Maria I Bergamasco, Alexandra L Garnham, Yifang Hu, Tim Thomas

PLoS Genet· October 2024

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Functional mapping of epigenetic regulators uncovers coordinated tumor suppression by the HBO1 and MLL1 complexes.
Yuning J Tang, Haiqing Xu, Nicholas W Hughes, Samuel H Kim, Paloma Ruiz, Tim Thomas

bioRxiv· August 2024

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The histone acetyltransferase KAT6B is required for hematopoietic stem cell development and function.
Maria I Bergamasco, Nishika Ranathunga, Waruni Abeysekera, Connie S N Li-Wai-Suen, Alexandra L Garnham, Tim Thomas

Stem Cell Reports· April 2024

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Increasing histone acetylation improves sociability and restores learning and memory in KAT6B-haploinsufficient mice.
Maria I Bergamasco, Hannah K Vanyai, Alexandra L Garnham, Niall D Geoghegan, Adam P Vogel, Tim Thomas

J Clin Invest· April 2024

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PHF6-mediated transcriptional control of NSC via Ephrin receptors is impaired in the intellectual disability syndrome BFLS.
Dilan Rasool, Audrey Burban, Ahmad Sharanek, Ariel Madrigal, Jinghua Hu, Tim Thomas

EMBO Rep· March 2024

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ING4 and ING5 are essential for histone H3 lysine 14 acetylation and epicardial cell lineage development.
Sophia Y Y Mah, Hannah K Vanyai, Connie S N Li-Wai-Suen, Alexandra L Garnham, Jessica Wynn, Tim Thomas

Development· March 2024

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Neutrophils determine immunotherapy success.
Tim Thomas

Nat Cancer· December 2023

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Discovery of a highly potent, selective, orally bioavailable inhibitor of KAT6A/B histone acetyltransferases with efficacy against KAT6A-high ER+ breast cancer.
Shikhar Sharma, Chi-Yeh Chung, Sean Uryu, Jelena Petrovic, Joan Cao, Thomas S Peat, Tim Thomas, Thomas A Paul

Cell Chem Biol· October 2023

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The chromatin reader protein ING5 is required for normal hematopoietic cell numbers in the fetal liver.
Sophia Y Y Mah, Hannah K Vanyai, Yuqing Yang, Anne K Voss, Tim Thomas

Front Immunol· June 2023

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Detecting lymph node metastases for personalized radiotherapy in patients with prostate cancer.
Tim Thomas

Nat Rev Urol· April 2023

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GHR expression and prostate cancer proliferation.
Tim Thomas

Nat Rev Urol· March 2023

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Semen quality recovery following COVID-19.
Tim Thomas

Nat Rev Urol· March 2023

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Semen parameters across testicular cancer stages.
Tim Thomas

Nat Rev Urol· March 2023

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Pembrolizumab + axitinib beyond first-line therapy for mRCC.
Tim Thomas

Nat Rev Urol· March 2023

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Reference compounds for characterizing cellular injury in high-content cellular morphology assays.
Jayme L Dahlin, Bruce K Hua, Beth E Zucconi, Shawn D Nelson, Shantanu Singh, Tim Thomas

Nat Commun· March 2023

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MRI diagnosis and radical prostatectomy outcomes.
Tim Thomas

Nat Rev Urol· February 2023

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An app for optimizing UTI screening.
Tim Thomas

Nat Rev Urol· February 2023

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Stem cell plasticity, acetylation of H3K14, and de novo gene activation rely on KAT7.
Andrew J Kueh, Maria I Bergamasco, Anna Quaglieri, Belinda Phipson, Connie S N Li-Wai-Suen, Tim Thomas

Cell Rep· January 2023

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FMD safe and feasible.
Tim Thomas

Nat Cancer· December 2022

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