Publications by authors named "Timo Vaara"

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An antibiotic derivative as a new potential tool in the prevention of hemolytic uremic syndrome.
Elisa Varrone, Luciano Consagra, Domenica Carnicelli, Elisabetta Galassi, Beatrice Munari, Timo Vaara, Martti Vaara

iScience· August 2025

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Excretion of the Polymyxin Derivative NAB739 in Murine Urine.
Martti Vaara, Timo Vaara, Janis Kuka, Eduards Sevostjanovs, Solveiga Grinberga

Antibiotics (Basel)· March 2020

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The polymyxin derivative NAB739 is synergistic with several antibiotics against polymyxin-resistant strains of Escherichia coli, Klebsiella pneumoniae and Acinetobacter baumannii.
Jonathan M Tyrrell, Ali F Aboklaish, Timothy R Walsh, Timo Vaara, Martti Vaara

Peptides· February 2019

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Human kidney on a chip assessment of polymyxin antibiotic nephrotoxicity.
Elijah J Weber, Kevin A Lidberg, Lu Wang, Theo K Bammler, James W MacDonald, Martti Vaara, Timo Vaara

JCI Insight· December 2018

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Polymyxin derivatives NAB739 and NAB815 are more effective than polymyxin B in murine Escherichia coli pyelonephritis.
Martti Vaara, Timo Vaara, Carina Vingsbo Lundberg

J Antimicrob Chemother· February 2018

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Structure-activity studies on polymyxin derivatives carrying three positive charges only reveal a new class of compounds with strong antibacterial activity.
Martti Vaara, Timo Vaara, Jonathan M Tyrrell

Peptides· May 2017

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Antimicrobial activity of the novel polymyxin derivative NAB739 tested against Gram-negative pathogens.
Martti Vaara, Helio S Sader, Paul R Rhomberg, Ronald N Jones, Timo Vaara

J Antimicrob Chemother· March 2013

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The novel polymyxin derivative NAB739 is remarkably less cytotoxic than polymyxin B and colistin to human kidney proximal tubular cells.
Martti Vaara, Timo Vaara

Int J Antimicrob Agents· March 2013

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Novel polymyxin derivatives are less cytotoxic than polymyxin B to renal proximal tubular cells.
Marie-Paule Mingeot-Leclercq, Paul M Tulkens, Sophie Denamur, Timo Vaara, Martti Vaara

Peptides· June 2012

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Structure-activity studies on novel polymyxin derivatives that carry only three positive charges.
Martti Vaara, Timo Vaara

Peptides· December 2010

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A novel polymyxin derivative that lacks the fatty acid tail and carries only three positive charges has strong synergism with agents excluded by the intact outer membrane.
Martti Vaara, Osmo Siikanen, Juha Apajalahti, John Fox, Niels Frimodt-Møller, Timo Vaara

Antimicrob Agents Chemother· August 2010

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Susceptibility of carbapenemase-producing strains of Klebsiella pneumoniae and Escherichia coli to the direct antibacterial activity of NAB739 and to the synergistic activity of NAB7061 with rifampicin and clarithromycin.
Martti Vaara, Osmo Siikanen, Juha Apajalahti, Niels Frimodt-Møller, Timo Vaara

J Antimicrob Chemother· May 2010

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Novel polymyxin derivatives are effective in treating experimental Escherichia coli peritoneal infection in mice.
Carina Vingsbo Lundberg, Timo Vaara, Niels Frimodt-Møller, Martti Vaara

J Antimicrob Chemother· May 2010

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Pharmacokinetics of novel antimicrobial cationic peptides NAB 7061 and NAB 739 in rats following intravenous administration.
Feda' Emad Atta Ali, Guoying Cao, Anima Poudyal, Timo Vaara, Roger L Nation, Martti Vaara

J Antimicrob Chemother· November 2009

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Novel polymyxin derivatives carrying only three positive charges are effective antibacterial agents.
Martti Vaara, John Fox, Günther Loidl, Osmo Siikanen, Juha Apajalahti, Timo Vaara

Antimicrob Agents Chemother· September 2008

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