Publications by authors named "Timothy A Springer"

Claim this Profile
A
A single-chain derivative of an integrin-activating antibody potentiates organoid growth in Matrigel and collagen hydrogels.
Wim B M de Lau, Joost J A P M Wijnakker, Gijs J F van Son, Daniel Krueger, Daisong Wang, Timothy A Springer

Nat Biotechnol· October 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
N
Nanobodies targeting EGFR provide insight into conformations stabilized by glioblastoma mutations.
Sean M Watson, Edward P Harvey, Novalia Pishesha, Hidde L Ploegh, Timothy A Springer

J Biol Chem· July 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
L
Ligand binding initiates single-molecule integrin conformational activation.
Jing Li, Myung Hyun Jo, Jiabin Yan, Taylor Hall, Joon Lee, Timothy A Springer

Cell· June 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Synthetic integrin antibodies discovered by yeast display reveal αV subunit pairing preferences with β subunits.
Yuxin Hao, Jiabin Yan, Courtney Fraser, Aiping Jiang, Murali Anuganti, Timothy A Springer

MAbs· June 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Synthetic integrin antibodies discovered by yeast display reveal αV subunit pairing preferences with β subunits.
Yuxin Hao, Jiabin Yan, Courtney Fraser, Aiping Jiang, Murali Anuganti, Timothy A Springer

bioRxiv· January 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Structural insights into MIC2 recognition by MIC2-associated protein in Toxoplasma gondii.
Su Zhang, Fangfang Wang, Dujuan Zhang, Dongsheng Liu, Wei Ding, Timothy A Springer

Commun Biol· August 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A recombinant technique for mapping functional sites of heterotrimeric collagen helices: Collagen IV CB3 fragment as a prototype for integrin binding.
Sergei P Boudko, Elizabeth H Konopka, Woojin Kim, Yuki Taga, Kazunori Mizuno, Timothy A Springer

J Biol Chem· July 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Conformational change of Plasmodium TRAP is essential for sporozoite migration and transmission.
Friedrich Braumann, Dennis Klug, Jessica Kehrer, Gaojie Song, Juan Feng, Timothy A Springer

EMBO Rep· July 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A specialized integrin-binding motif enables proTGF-β2 activation by integrin αVβ6 but not αVβ8.
Viet Q Le, Bo Zhao, Siddanth Ramesh, Cameron Toohey, Adam DeCosta, Timothy A Springer

Proc Natl Acad Sci U S A· June 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Conformation of von Willebrand factor in shear flow revealed with stroboscopic single-molecule imaging.
Hans T Bergal, Yan Jiang, Darren Yang, Timothy A Springer, Wesley P Wong

Blood· December 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Single-molecule characterization of subtype-specific β1 integrin mechanics.
Myung Hyun Jo, Jing Li, Valentin Jaumouillé, Yuxin Hao, Jessica Coppola, Timothy A Springer

Nat Commun· December 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
R
Reflections on Integrins-Past, Present, and Future: The Albert Lasker Basic Medical Research Award.
Richard O Hynes, Erkki Ruoslahti, Timothy A Springer

JAMA· October 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Structures of VWF tubules before and after concatemerization reveal a mechanism of disulfide bond exchange.
Jacob R Anderson, Jing Li, Timothy A Springer, Alan Brown

Blood· September 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Dynamics of integrin α5β1, fibronectin, and their complex reveal sites of interaction and conformational change.
Yang Su, Roxana E Iacob, Jing Li, John R Engen, Timothy A Springer

J Biol Chem· September 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A general chemical principle for creating closure-stabilizing integrin inhibitors.
Fu-Yang Lin, Jing Li, Yonghua Xie, Jianghai Zhu, Thi Thu Huong Nguyen, Timothy A Springer

Cell· September 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
Monomeric prefusion structure of an extremophile gamete fusogen and stepwise formation of the postfusion trimeric state.
Juan Feng, Xianchi Dong, Yang Su, Chafen Lu, Timothy A Springer

Nat Commun· July 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
R
Regulation of integrin α5β1 conformational states and intrinsic affinities by metal ions and the ADMIDAS.
Jordan M Anderson, Jing Li, Timothy A Springer

Mol Biol Cell· May 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
V
Von Willebrand factor A1 domain stability and affinity for GPIbα are differentially regulated by its -glycosylated N- and C-linker.
Klaus Bonazza, Roxana E Iacob, Nathan E Hudson, Jing Li, Chafen Lu, Timothy A Springer

Elife· May 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
L
Loss of LRRC33-Dependent TGFβ1 Activation Enhances Antitumor Immunity and Checkpoint Blockade Therapy.
Aiping Jiang, Yan Qin, Timothy A Springer

Cancer Immunol Res· April 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Protection of the Prodomain α1-Helix Correlates with Latency in the Transforming Growth Factor-β Family.
Viet Q Le, Roxana E Iacob, Bo Zhao, Yang Su, Yuan Tian, Timothy A Springer

J Mol Biol· March 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Congenital X-linked neutropenia with myelodysplasia and somatic tetraploidy due to a germline mutation in SEPT6.
Raffaele Renella, Katelyn Gagne, Ellen Beauchamp, Jonathan Fogel, Aleksej Perlov, Timothy A Springer

Am J Hematol· January 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
L
Low-affinity integrin states have faster ligand-binding kinetics than the high-affinity state.
Jing Li, Jiabin Yan, Timothy A Springer

Elife· December 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Single-molecule imaging of von Willebrand factor reveals tension-dependent self-association.
Hongxia Fu, Yan Jiang, Wesley P Wong, Timothy A Springer

Blood· December 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Structural basis of malaria transmission blockade by a monoclonal antibody to gamete fusogen HAP2.
Juan Feng, Xianchi Dong, Adam DeCosta, Yang Su, Fiona Angrisano, Timothy A Springer

Elife· December 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Complement Receptor 3 Forms a Compact High-Affinity Complex with iC3b.
Rasmus K Jensen, Goran Bajic, Mehmet Sen, Timothy A Springer, Thomas Vorup-Jensen

J Immunol· June 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis