Publications by authors named "Timothy Affolter"

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18F-FLT PET, a Noninvasive Pharmacodynamic Biomarker of Tumor Cell Proliferation, Detected Differential Response to Various Cyclin-Dependent Kinase (CDK) Inhibitors.
Anand Giddabasappa, Ziyue Karen Jiang, Bing Yang, Laigao Chen, Feng Liu, Timothy Affolter

Mol Cancer Ther· July 2025

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Efficacy and Imaging-Enabled Pharmacodynamic Profiling of KRAS G12C Inhibitors in Xenograft and Genetically Engineered Mouse Models of Cancer.
Catherine Lee, Ziyue Karen Jiang, Simon Planken, Lisa K Manzuk, Roberto Ortiz, Timothy Affolter

Mol Cancer Ther· July 2023

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T cells and monocyte-derived myeloid cells mediate immunotherapy-related hepatitis in a mouse model.
Heather P Llewellyn, Seda Arat, Jingjin Gao, Ji Wen, Shuhua Xia, Timothy Affolter

J Hepatol· November 2021

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Inhibition of immune checkpoints PD-1, CTLA-4, and IDO1 coordinately induces immune-mediated liver injury in mice.
Timothy Affolter, Heather P Llewellyn, Derek W Bartlett, Qing Zong, Shuhua Xia

PLoS One· February 2020

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PF-06463922, an ALK/ROS1 Inhibitor, Overcomes Resistance to First and Second Generation ALK Inhibitors in Preclinical Models.
Helen Y Zou, Luc Friboulet, David P Kodack, Lars D Engstrom, Qiuhua Li, Timothy Affolter

Cancer Cell· July 2015

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Phenotype of TPBG Gene Replacement in the Mouse and Impact on the Pharmacokinetics of an Antibody-Drug Conjugate.
George Hu, Mauricio Leal, Qingcong Lin, Timothy Affolter, Puja Sapra

Mol Pharm· June 2015

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PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking crizotinib-resistant ROS1 mutations.
Helen Y Zou, Qiuhua Li, Lars D Engstrom, Melissa West, Vicky Appleman, Timothy Affolter

Proc Natl Acad Sci U S A· March 2015

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Axitinib and crizotinib combination therapy inhibits bone loss in a mouse model of castration resistant prostate cancer.
Jeetendra Eswaraka, Anand Giddabasappa, Guangzhou Han, Kush Lalwani, Koleen Eisele, Timothy Affolter

BMC Cancer· October 2014

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Investigation of ocular events associated with taprenepag isopropyl, a topical EP2 agonist in development for treatment of glaucoma.
Gina M Yanochko, Timothy Affolter, Johnnie J Eighmy, Mark G Evans, Su Khoh-Reiter

J Ocul Pharmacol Ther· June 2014

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Anti-IL-7 receptor-α reverses established type 1 diabetes in nonobese diabetic mice by modulating effector T-cell function.
Li-Fen Lee, Kathryn Logronio, Guang Huan Tu, Wenwu Zhai, Irene Ni, Timothy Affolter

Proc Natl Acad Sci U S A· July 2012

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[(18)F]FLT-PET imaging does not always "light up" proliferating tumor cells.
Cathy C Zhang, Zhengming Yan, Wenlin Li, Kyle Kuszpit, Cory L Painter, Timothy Affolter

Clin Cancer Res· March 2012

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Mycobacterium tuberculosis complex infection in a dog.
Jane E Sykes, Allison B Cannon, Aimee J Norris, Barbara A Byrne, Timothy Affolter

J Vet Intern Med· December 2007

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