Publications by authors named "Timothy B Doyle"

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Activity of aztreonam-avibactam and ceftazidime-avibactam against β-lactamase-producing enterobacterales Isolates from United States hospitals.
Lalitagauri M Deshpande, Timothy B Doyle, Helio S Sader, Mariana Castanheira

J Glob Antimicrob Resist· September 2025

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Antimicrobial susceptibility of clinical isolates of Stenotrophomonas maltophilia from Europe, Asia, and Latin America (2018-2023).
Helio S Sader, Rodrigo E Mendes, Timothy B Doyle, Marisa L Winkler, Mariana Castanheira

Int J Infect Dis· April 2025

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Antimicrobial susceptibility of from United States medical centers (2019-2023).
Helio S Sader, Mariana Castanheira, S J Ryan Arends, Timothy B Doyle

Antimicrob Agents Chemother· April 2025

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Frequency, Antimicrobial Susceptibility, and Molecular Characterization of Carbapenem-Resistant Enterobacterales Stratified by United States Census Divisions: Results From the INFORM Program (2018-2022).
Helio S Sader, John H Kimbrough, Timothy B Doyle, Marisa L Winkler, Mariana Castanheira

Open Forum Infect Dis· April 2025

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Characterization of and Species Complex Isolates with Decreased Susceptibility to Cephalosporins from United States Hospitals and Activity of Aztreonam-Avibactam and Comparator Agents (2019-2023).
Helio S Sader, Timothy B Doyle, John H Kimbrough, Rodrigo E Mendes, Mariana Castanheira

Antibiotics (Basel)· April 2025

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Activity of Aztreonam-avibactam and other β-lactamase inhibitor combinations against Gram-negative bacteria isolated from patients hospitalized with pneumonia in United States medical centers (2020-2022).
Helio S Sader, Rodrigo E Mendes, S J Ryan Arends, Timothy B Doyle, Mariana Castanheira

BMC Pulm Med· January 2025

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development of resistance against antipseudomonal agents: comparison of novel β-lactam/β-lactamase inhibitor combinations and other β-lactam agents.
Mariana Castanheira, John H Kimbrough, Jill Lindley, Timothy B Doyle, Jessica M Ewald

Antimicrob Agents Chemother· May 2024

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Engineered phage with antibacterial CRISPR-Cas selectively reduce E. coli burden in mice.
Yilmaz Emre Gencay, Džiuginta Jasinskytė, Camille Robert, Szabolcs Semsey, Virginia Martínez, Timothy B Doyle

Nat Biotechnol· February 2024

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Vaborbactam increases meropenem susceptibility in clinical isolates displaying MexXY and AmpC upregulation.
Mariana Castanheira, Timothy B Doyle, Cory M Hubler, Sean DeVries, Dee Shortridge

mSphere· October 2023

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In Vitro Selection of Enterobacter cloacae with Cefepime, Meropenem, and Ceftazidime-Avibactam Generates Diverse Resistance Mechanisms.
Mariana Castanheira, Jill Lindley, Timothy B Doyle, Andrew P Davis, Helio S Sader

Int J Antimicrob Agents· January 2023

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The plethora of resistance mechanisms in Pseudomonas aeruginosa: transcriptome analysis reveals a potential role of lipopolysaccharide pathway proteins to novel β-lactam/β-lactamase inhibitor combinations.
Mariana Castanheira, Timothy B Doyle, Cory M Hubler, Timothy D Collingsworth, Sean DeVries

J Glob Antimicrob Resist· December 2022

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Prevalence of carbapenemase genes among carbapenem-nonsusceptible collected in US hospitals in a five-year period and activity of ceftazidime/avibactam and comparator agents.
Mariana Castanheira, Lalitagauri M Deshpande, Rodrigo E Mendes, Timothy B Doyle, Helio S Sader

JAC Antimicrob Resist· October 2022

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Increasing frequency of OXA-48-producing Enterobacterales worldwide and activity of ceftazidime/avibactam, meropenem/vaborbactam and comparators against these isolates.
Mariana Castanheira, Timothy B Doyle, Timothy D Collingsworth, Helio S Sader, Rodrigo E Mendes

J Antimicrob Chemother· November 2021

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Activity of ceftazidime/avibactam, meropenem/vaborbactam and imipenem/relebactam against carbapenemase-negative carbapenem-resistant Enterobacterales isolates from US hospitals.
Mariana Castanheira, Timothy B Doyle, Lalitagauri M Deshpande, Rodrigo E Mendes, Helio S Sader

Int J Antimicrob Agents· November 2021

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Investigation of mechanisms responsible for decreased susceptibility of aztreonam/avibactam activity in clinical isolates of Enterobacterales collected in Europe, Asia and Latin America in 2019.
Rodrigo E Mendes, Timothy B Doyle, Jennifer M Streit, Francis F Arhin, Helio S Sader

J Antimicrob Chemother· October 2021

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Characterization of and species complex isolates with decreased susceptibility to cephalosporins from United States hospitals and activity of ceftazidime/avibactam and comparator agents.
Helio S Sader, Rodrigo E Mendes, Timothy B Doyle, Andrew P Davis, Mariana Castanheira

JAC Antimicrob Resist· September 2021

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Antimicrobial activity of ceftazidime/avibactam, ceftolozane/tazobactam and comparator agents against from cystic fibrosis patients.
Helio S Sader, Leonard R Duncan, Timothy B Doyle, Mariana Castanheira

JAC Antimicrob Resist· September 2021

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Antimicrobial Activity of Ceftazidime-Avibactam, Ceftolozane-Tazobactam and Comparators Tested Against and Isolates from United States Medical Centers in 2016-2018.
Helio S Sader, Cecilia G Carvalhaes, Jennifer M Streit, Timothy B Doyle, Mariana Castanheira

Microb Drug Resist· March 2021

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Media for colistin susceptibility testing does not improve the detection of Klebsiella pneumoniae isolates carrying MgrB disruption and other mutation driven colistin resistance mechanisms.
Mariana Castanheira, Timothy B Doyle, Cecilia G Carvalhaes, Brieanna M Roth, Paul R Rhomberg

Diagn Microbiol Infect Dis· September 2020

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Ceftazidime-avibactam activity against a challenge set of carbapenem-resistant Enterobacterales: Ompk36 L3 alterations and β-lactamases with ceftazidime hydrolytic activity lead to elevated MIC values.
Mariana Castanheira, Timothy B Doyle, Cory Hubler, Helio S Sader, Rodrigo E Mendes

Int J Antimicrob Agents· July 2020

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Correction for Castanheira et al., "Meropenem-Vaborbactam Activity against Carbapenem-Resistant Isolates Collected in U.S. Hospitals during 2016 to 2018".
Mariana Castanheira, Timothy B Doyle, Valerie Kantro, Rodrigo E Mendes, Dee Shortridge

Antimicrob Agents Chemother· March 2020

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Meropenem-Vaborbactam Activity against Carbapenem-Resistant Isolates Collected in U.S. Hospitals during 2016 to 2018.
Mariana Castanheira, Timothy B Doyle, Valerie Kantro, Rodrigo E Mendes, Dee Shortridge

Antimicrob Agents Chemother· January 2020

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Combination of MexAB-OprM overexpression and mutations in efflux regulators, PBPs and chaperone proteins is responsible for ceftazidime/avibactam resistance in Pseudomonas aeruginosa clinical isolates from US hospitals.
Mariana Castanheira, Timothy B Doyle, Caitlin J Smith, Rodrigo E Mendes, Helio S Sader

J Antimicrob Chemother· September 2019

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Comparative Activities of Ceftazidime-Avibactam and Ceftolozane-Tazobactam against Enterobacteriaceae Isolates Producing Extended-Spectrum β-Lactamases from U.S. Hospitals.
Mariana Castanheira, Timothy B Doyle, Rodrigo E Mendes, Helio S Sader

Antimicrob Agents Chemother· July 2019

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Low Prevalence of Gram-Positive Isolates Showing Elevated Lefamulin MIC Results during the SENTRY Surveillance Program for 2015-2016 and Characterization of Resistance Mechanisms.
Rodrigo E Mendes, Susanne Paukner, Timothy B Doyle, Steven P Gelone, Robert K Flamm

Antimicrob Agents Chemother· April 2019

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