Publications by authors named "Timothy D Cushing"

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Discovery and in Vivo Evaluation of the Potent and Selective PI3Kδ Inhibitors 2-((1S)-1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-6-fluoro-N-methyl-3-(2-pyridinyl)-4-quinolinecarboxamide (AM-0687) and 2-((1S)-1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-5-fluoro-N-methyl-3-(2-pyridinyl)-4-quinolinecarboxamide (AM-1430).
Felix Gonzalez-Lopez de Turiso, Xiaolin Hao, Youngsook Shin, Minna Bui, Iain D G Campuzano, Timothy D Cushing

J Med Chem· August 2016

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Discovery, Optimization, and in Vivo Evaluation of Benzimidazole Derivatives AM-8508 and AM-9635 as Potent and Selective PI3Kδ Inhibitors.
Youngsook Shin, Julia Suchomel, Mario Cardozo, Jason Duquette, Xiao He, Timothy D Cushing

J Med Chem· January 2016

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Synthesis and SAR study of potent and selective PI3Kδ inhibitors.
Minna Bui, Xiaolin Hao, Youngsook Shin, Mario Cardozo, Xiao He, Timothy D Cushing

Bioorg Med Chem Lett· March 2015

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Discovery and in vivo evaluation of (S)-N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine (AMG319) and related PI3Kδ inhibitors for inflammation and autoimmune disease.
Timothy D Cushing, Xiaolin Hao, Youngsook Shin, Kristin Andrews, Matthew Brown

J Med Chem· January 2015

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Inhibiting NF-κB-inducing kinase (NIK): discovery, structure-based design, synthesis, structure-activity relationship, and co-crystal structures.
Kexue Li, Lawrence R McGee, Ben Fisher, Athena Sudom, Jinsong Liu, Timothy D Cushing

Bioorg Med Chem Lett· March 2013

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Discovery of INT131: a selective PPARγ modulator that enhances insulin sensitivity.
Joshua P Taygerly, Lawrence R McGee, Steven M Rubenstein, Jonathan B Houze, Timothy D Cushing

Bioorg Med Chem· February 2013

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PI3Kδ and PI3Kγ as targets for autoimmune and inflammatory diseases.
Timothy D Cushing, Daniela P Metz, Douglas A Whittington, Lawrence R McGee

J Med Chem· October 2012

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Discovery and in vivo evaluation of dual PI3Kβ/δ inhibitors.
Felix Gonzalez-Lopez de Turiso, Youngsook Shin, Matthew Brown, Mario Cardozo, Yi Chen, Timothy D Cushing

J Med Chem· September 2012

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A novel series of IKKβ inhibitors part II: description of a potent and pharmacologically active series of analogs.
Timothy D Cushing, Vijay Baichwal, Karen Berry, Roland Billedeau, Viola Bordunov

Bioorg Med Chem Lett· January 2011

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A novel series of IKKβ inhibitors part I: Initial SAR studies of a HTS hit.
Timothy D Cushing, Vijay Baichwal, Karen Berry, Roland Billedeau, Viola Bordunov

Bioorg Med Chem Lett· January 2011

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