Publications by authors named "Timothy D O'Brien"

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Consistent self-organized emergence of hyaline cartilage in human induced pluripotent stem cell-derived multi-tissue organoids.
Huzefa I Husain, Manci Li, Juan E Abrahante, Natalia Calixto Mancipe, Amanda Vegoe, Timothy D O'Brien

Stem Cells· September 2025

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Hemangiosarcoma Cells Promote Conserved Host-derived Hematopoietic Expansion.
Jong Hyuk Kim, Ashley J Schulte, Aaron L Sarver, Donghee Lee, Mathew G Angelos, Timothy D O'Brien

Cancer Res Commun· June 2024

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A bioengineered artificial interstitium supports long-term islet xenograft survival in nonhuman primates without immunosuppression.
Scott H Oppler, Laura L Hocum Stone, David J Leishman, Jody L Janecek, Meghan E G Moore, Timothy D O'Brien

Sci Adv· January 2024

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Targeted mapping and utilization of the perihepatic surface for therapeutic beta cell replacement and retrieval in diabetic non-human primates.
David J Leishman, Scott H Oppler, Laura L Hocum Stone, Timothy D O'Brien, Sabarinathan Ramachandran

Front Transplant· January 2024

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Hypoxia within subcutaneously implanted macroencapsulation devices limits the viability and functionality of densely loaded islets.
Samuel A Einstein, Leah V Steyn, Bradley P Weegman, Thomas M Suszynski, Athanassios Sambanis, Timothy D O'Brien

Front Transplant· November 2023

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Missense variant in RBM10 associated with mild and non-lethal form of TARP syndrome.
Amiee B Potter, Timothy D O'Brien, Arpita Kulkarni, Sarah McCabe, Kathryn Matthews

Clin Genet· August 2023

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Population screening shows risk of inherited cancer and familial hypercholesterolemia in Oregon.
Timothy D O'Brien, Amiee B Potter, Catherine C Driscoll, Gregory Goh, John H Letaw

Am J Hum Genet· August 2023

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Clinically available immunosuppression averts rejection but not systemic inflammation after porcine islet xenotransplant in cynomolgus macaques.
Melanie L Graham, Sabarinathan Ramachandran, Amar Singh, Meghan E G Moore, E Brian Flanagan, Timothy D O'Brien

Am J Transplant· March 2022

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Artificial intelligence (AI)-assisted exome reanalysis greatly aids in the identification of new positive cases and reduces analysis time in a clinical diagnostic laboratory.
Timothy D O'Brien, N Eleanor Campbell, Amiee B Potter, John H Letaw, Arpita Kulkarni

Genet Med· January 2022

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Development of an exosomal gene signature to detect residual disease in dogs with osteosarcoma using a novel xenograft platform and machine learning.
Kelly M Makielski, Alicia J Donnelly, Ali Khammanivong, Milcah C Scott, Andrea R Ortiz, Timothy D O'Brien

Lab Invest· December 2021

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Characterization of genome-wide association study data reveals spatiotemporal heterogeneity of mental disorders.
Yulin Dai, Timothy D O'Brien, Guangsheng Pei, Zhongming Zhao, Peilin Jia

BMC Med Genomics· December 2020

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A novel MCT1 and MCT4 dual inhibitor reduces mitochondrial metabolism and inhibits tumour growth of feline oral squamous cell carcinoma.
Ali Khammanivong, Jhuma Saha, Angela K Spartz, Brent S Sorenson, Alexander G Bush, Timothy D O'Brien

Vet Comp Oncol· September 2020

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Interspecies Organogenesis for Human Transplantation.
Andrew T Crane, Rajagopal N Aravalli, Atsushi Asakura, Andrew W Grande, Venkatramana D Krishna, Timothy D O'Brien

Cell Transplant· August 2020

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What is your diagnosis? Nasal lesion in a horse with exophthalmos.
Ashley E Zibura, Leah K Manning, Angela Gwynn, Leslie Sharkey, Michala de Linde Henriksen, Timothy D O'Brien

Vet Clin Pathol· December 2019

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Lung Cancer: One Disease or Many.
Timothy D O'Brien, Peilin Jia, Melinda C Aldrich, Zhongming Zhao

Hum Hered· March 2019

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Weak sharing of genetic association signals in three lung cancer subtypes: evidence at the SNP, gene, regulation, and pathway levels.
Timothy D O'Brien, Peilin Jia, Neil E Caporaso, Maria Teresa Landi, Zhongming Zhao

Genome Med· February 2018

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Comparative Transcriptome Analysis Quantifies Immune Cell Transcript Levels, Metastatic Progression, and Survival in Osteosarcoma.
Milcah C Scott, Nuri A Temiz, Anne E Sarver, Rebecca S LaRue, Susan K Rathe, Timothy D O'Brien

Cancer Res· January 2018

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Constitutive activation of alternative nuclear factor kappa B pathway in canine diffuse large B-cell lymphoma contributes to tumor cell survival and is a target of new adjuvant therapies.
Davis M Seelig, Daisuke Ito, Colleen L Forster, Una A Yoon, Matthew Breen, Timothy D O'Brien

Leuk Lymphoma· July 2017

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Generation of induced pluripotent stem cells from Chinese hamster embryonic fibroblasts.
Haiyun Pei, Hsu-Yuan Fu, Hiroyuki Hirai, Dong Seong Cho, Timothy D O'Brien

Stem Cell Res· May 2017

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Eradication of Canine Diffuse Large B-Cell Lymphoma in a Murine Xenograft Model with CD47 Blockade and Anti-CD20.
Kipp Weiskopf, Katie L Anderson, Daisuke Ito, Peter J Schnorr, Hirotaka Tomiyasu, Timothy D O'Brien

Cancer Immunol Res· December 2016

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Plasticity and Aggregation of Juvenile Porcine Islets in Modified Culture: Preliminary Observations.
Bradley P Weegman, Michael J Taylor, Simona C Baicu, Kate Mueller, Timothy D O'brien

Cell Transplant· October 2016

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Anti-Insulin Immune Responses Are Detectable in Dogs with Spontaneous Diabetes.
Jong-Hyuk Kim, Eva Furrow, Michelle G Ritt, Paul J Utz, William H Robinson, Timothy D O'Brien

PLoS One· August 2016

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Rapid Induction of Cerebral Organoids From Human Induced Pluripotent Stem Cells Using a Chemically Defined Hydrogel and Defined Cell Culture Medium.
Beth A Lindborg, John H Brekke, Amanda L Vegoe, Connor B Ulrich, Kerri T Haider, Timothy D O'Brien

Stem Cells Transl Med· July 2016

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Porcine lung mesenchymal stromal cells possess differentiation and immunoregulatory properties.
Mahesh Khatri, Timothy D O'Brien, Kuldeep S Chattha, Linda J Saif

Stem Cell Res Ther· November 2015

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Canine adipose-derived stromal cell viability following exposure to synovial fluid from osteoarthritic joints.
Kristina M Kiefer, Timothy D O'Brien, Elizabeth G Pluhar, Michael Conzemius

Vet Rec Open· September 2015

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