Publications by authors named "Timothy Frankel"

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Immunocompetent Murine Models Recapitulate the Heterogeneous Tumor-Immune Microenvironment of Human Liposarcoma.
Amanda M Shafer, Emma Kenna, Lexi-Ann F Golden, Ahmed M Elhossiny, Kyle D Perry, Timothy L Frankel

Clin Cancer Res· December 2025

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EGFR activation in cholangiocytes promotes extrahepatic bile duct regeneration after injury.
Ashley N Calder, Takuki Sakaguchi, Mirabelle Peter, John Tobias, Timothy Frankel

Hepatol Commun· November 2025

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A metabolic atlas of mouse aging.
Steven E Pilley, Dominik Awad, Djakim Latumalea, Connie New, Edgar Esparza, Timothy L Frankel

Cell Metab· November 2025

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Wilm's Tumor 1-Expressing Stromal Cells Promote Pancreatic Cancer Progression.
Allison C Bischoff, Kristee Brown, Emily L Lasse Opsahl, Hannah R Watkoske, Carlos E Espinoza, Timothy L Frankel

Cancer Res· October 2025

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Fibroblast STAT3 Activation Drives Organ-Specific Premetastatic Niche Formation.
Emily L Lasse Opsahl, Carlos E Espinoza, Alberto C Olivei, Jude Ogechukwu Okoye, Hannah Watkoske, Timothy L Frankel

Cancer Res· October 2025

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Aryl hydrocarbon receptor ligands drive pancreatic cancer initiation and progression through pro-tumorigenic T cell polarization.
Brian D Griffith, Padma Kadiyala, Jake McGue, Lei Sun, Aadith Kumar, Timothy L Frankel

Cancer Discov· September 2025

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Primary and metastatic cellular landscapes in human pancreatic cancer.
Nina G Steele, Veerin R Sirihorachai, Ahmed M Elhossiny, Ian M Loveless, Padma Kadiyala, Timothy L Frankel

iScience· August 2025

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IL-22BP Modulates Injury in Acute Pancreatitis but Delays Tissue Recovery in Chronic Pancreatitis.
Lei Sun, Andrew G Spiteri, Brian D Griffith, Yaqing Zhang, Marina Pasca Di Magliano, Timothy L Frankel

Cell Mol Gastroenterol Hepatol· July 2025

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Pancreatic cancer precursor lesions - Can immunotherapy prevent progression into pancreatic ductal adenocarcinoma?
Thomas Enzler, Timothy L Frankel

Cancer Lett· June 2025

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Spatial analysis reveals a novel inflammatory tumor transition state which promotes a macrophage-driven induction of sarcomatoid renal cell carcinoma.
Allison M May, Suguru Kadomoto, Claire Williams, Alex C Soupir, Stephanie The, Timothy L Frankel

bioRxiv· June 2025

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Spatial Transcriptomics of Intraductal Papillary Mucinous Neoplasms Reveals Divergent Indolent and Malignant States.
Matthew K Iyer, Ashley A Fletcher, Jude Ogechukwu Okoye, Chanjuan Shi, Fengming Chen, Timothy L Frankel

Clin Cancer Res· May 2025

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Mouse Models for Pancreatic Ductal Adenocarcinoma are Affected by the cre-driver Used to Promote KRAS Activation.
Fatemeh Mousavi, Joyce Thompson, Justine Lau, Nur Renollet, Mickenzie B Martin, Timothy Frankel

Cell Mol Gastroenterol Hepatol· April 2025

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Role of Immunotherapy in the Treatment of Hepatocellular Carcinoma.
Irina Y Dobrosotskaya, Rashmi Kumar, Timothy L Frankel

Curr Oncol· April 2025

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EGFR activation in cholangiocytes promotes extrahepatic bile duct regeneration after injury.
Ashley N Calder, Takuki Sakaguchi, Mirabelle Peter, John Tobias, Timothy Frankel

bioRxiv· April 2025

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Spatial analysis of IPMNs defines a paradoxical KRT17-positive, low-grade epithelial population harboring malignant features.
Jay Li, Justin Macchia, Ahmed M Elhossiny, Nandini Arya, Padma Kadiyala, Timothy L Frankel

bioRxiv· March 2025

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An immunocompetent mouse model of liposarcoma.
Amanda M Shafer, Emma Kenna, Lexi-Ann F Golden, Ahmed M Elhossiny, Kyle D Perry, Timothy L Frankel

bioRxiv· February 2025

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Characterization of undifferentiated carcinomas of the pancreas with and without osteoclast-like giant cells.
Jamie N Mills, Valerie Gunchick, Jake McGue, Zhaoping Qin, Chandan Kumar-Sinha, Timothy Frankel

JNCI Cancer Spectr· January 2025

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KRASG12D drives immunosuppression in lung adenocarcinoma through paracrine signaling.
Emily L Lasse-Opsahl, Ivana Barravecchia, Elyse McLintock, Jennifer M Lee, Sarah F Ferris, Timothy L Frankel

JCI Insight· January 2025

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WNT signaling contributes to the extrahepatic bile duct proliferative response to obstruction in mice.
Ashley N Calder, Mirabelle Q Peter, John W Tobias, Nureen H Mohamad Zaki, Theresa M Keeley, Timothy L Frankel

JCI Insight· December 2024

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Isolation and characterization of microbiota from human pancreatic tumors and small intestine.
Dominik Awad, Holly Attebury, Ryan Hong, Kwi Kim, Li Zhang, Timothy Frankel

bioRxiv· December 2024

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Proximogram-A multi-omics network-based framework to capture tissue heterogeneity integrating single-cell omics and spatial profiling.
Santhoshi N Krishnan, Sunjong Ji, Ahmed M Elhossiny, Achyutha Rao, Timothy L Frankel

Comput Biol Med· November 2024

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SLC4A11 mediates ammonia import and promotes cancer stemness in hepatocellular carcinoma.
Ameer L Elaimy, Marwa O El-Derany, Jadyn James, Zhuwen Wang, Ashley N Pearson, Timothy L Frankel

JCI Insight· November 2024

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Assessing the Tumor Immune Landscape Across Multiple Spatial Scales to Differentiate Immunotherapy Response in Metastatic Non-Small Cell Lung Cancer.
Ashley P Tsang, Santhoshi N Krishnan, Joel N Eliason, Jake J McGue, Angel Qin, Timothy L Frankel

Lab Invest· November 2024

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Spatial Transcriptomics of IPMN Reveals Divergent Indolent and Malignant Lineages.
Matthew K Iyer, Ashley Fletcher, Chanjuan Shi, Fengming Chen, Elishama Kanu, Timothy L Frankel

bioRxiv· November 2024

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Metabolic landscape of the healthy pancreas and pancreatic tumor microenvironment.
Monica E Bonilla, Megan D Radyk, Matthew D Perricone, Ahmed M Elhossiny, Alexis C Harold, Timothy L Frankel

JCI Insight· August 2024

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