Publications by authors named "Timothy Hagen"

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Synthesis and evaluation of acyl-AMP phosphate isosteres as inhibitors of fungal acetyl CoA synthetase.
Drashti G Daraji, Andrew J Jezewski, Katy M Alden, Jonah P Propp, Michael E Heene, Timothy J Hagen

Bioorg Med Chem Lett· December 2025

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Discovery and mechanism of a highly selective, antifungal acetyl-CoA synthetase inhibitor.
Andrew J Jezewski, Katy M Alden, Jonah Propp, Drashti G Daraji, Charles L Lail, Timothy J Hagen

Nat Commun· October 2025

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Analysis of Burkholderia pseudomallei IspF in complex with sulfapyridine, sulfamonomethoxine, ethoxzolamide and acetazolamide.
Dakota Grote, Christopher G Stewart, Drashti G Daraji, Parisa Enayati, Kristina N Braverman, Timothy J Hagen

Acta Crystallogr F Struct Biol Commun· April 2025

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Discovery and mechanism of a highly selective, antifungal acetyl CoA synthetase inhibitor.
Andrew J Jezewski, Katy M Alden, Drashti G Daraji, Charles L Lail, Jonah Propp, Timothy J Hagen

Res Sq· January 2025

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Inhibitors of Rickettsia prowazekii methionine aminopeptidase 1 identified from the Pandemic Response Box.
Ishpriya Sharma, Drashti Daraji, James R Horn, Timothy J Hagen

Bioorg Med Chem Lett· November 2024

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A single Leishmania adenylate-forming enzyme of the ANL superfamily generates both acetyl- and acetoacetyl-CoA.
Andrew J Jezewski, Taiwo E Esan, Jonah Propp, Andrew J Fuller, Drashti G Daraji, Timothy J Hagen

J Biol Chem· November 2024

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Crystal structure and biophysical characterization of IspD from Burkholderia thailandensis and Mycobacterium paratuberculosis.
Phillip G Pierce, Brian E Hartnett, Tosha M Laughlin, Joy M Blain, Stephen J Mayclin, Timothy J Hagen

Acta Crystallogr F Struct Biol Commun· February 2024

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Bacterial structural genomics target enabled by a recently discovered potent fungal acetyl-CoA synthetase inhibitor.
Nicholas D DeBouver, Madison J Bolejack, Taiwo E Esan, Damian J Krysan, Timothy J Hagen

Acta Crystallogr F Struct Biol Commun· June 2023

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Novel inhibitors of Rickettsia prowazekii methionine aminopeptidase from the Malaria Box.
Ishpriya Sharma, Congling Chen, Drashti Daraji, James R Horn, Timothy J Hagen

Bioorg Med Chem Lett· May 2023

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Novel Keto-Alkyl-Pyridinium Antifungal Molecules Active in Models of Candida albicans Vascular Catheter Infection and Candida auris Skin Colonization.
Sarah R Beattie, Taiwo Esan, Robert Zarnowski, Emily Eix, Jeniel E Nett, Timothy Hagen

Antimicrob Agents Chemother· May 2023

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Evaluation of an implementation package to deliver the COPD CARE service.
Edward Portillo, Molly Lehmann, Timothy Hagen, Martha Maurer, Jordyn Kettner

BMJ Open Qual· February 2023

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Novel keto-alkyl-pyridinium antifungal molecules active in models of in vivo vascular catheter infection and ex vivo skin colonization.
Sarah R Beattie, Taiwo Esan, Robert Zarnowski, Emily Eix, Jeniel E Nett, Timothy Hagen

bioRxiv· January 2023

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Traditional Kenyan herbal medicine: exploring natural products' therapeutics against schistosomiasis.
Fidensio K Ndegwa, Chaitanya Kondam, Samuel Y Aboagye, Taiwo E Esan, Zohra Sattar Waxali, Timothy J Hagen

J Helminthol· March 2022

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Structural and biophysical characterization of the Burkholderia pseudomallei IspF inhibitor L-tryptophan hydroxamate.
Joy M Blain, Dakota L Grote, Sydney M Watkins, Gashaw M Goshu, Chanté Muller, Timothy J Hagen

Bioorg Med Chem Lett· September 2021

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Structural Characterization of the Reaction and Substrate Specificity Mechanisms of Pathogenic Fungal Acetyl-CoA Synthetases.
Andrew J Jezewski, Katy M Alden, Taiwo E Esan, Nicholas D DeBouver, Jan Abendroth, Timothy J Hagen

ACS Chem Biol· August 2021

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Antibacterial activity of 2-amino-4-hydroxypyrimidine-5-carboxylates and binding to Burkholderia pseudomallei 2-C-methyl-d-erythritol-2,4-cyclodiphosphate synthase.
Sydney M Watkins, Debarati Ghose, Joy M Blain, Dakota L Grote, Chi-Hao Luan, Timothy J Hagen

Bioorg Med Chem Lett· October 2019

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Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders.
Mark E Gurney, Richard A Nugent, Xuesheng Mo, Janice A Sindac, Timothy J Hagen

J Med Chem· May 2019

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Dissemination of Imidacloprid Through Dairy Cattle Manure and Its Effect on the Biological Control Agent, Spalangia endius (Hymenoptera: Pteromalidae), and a Filth Fly Host, Musca domestica (Diptera: Muscidae).
Edwin R Burgess, Sydney M Watkins, Bethia H King, Karley Chantos-Davidson, Aspen N Kremer, Timothy J Hagen

J Econ Entomol· March 2019

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Compound D159687, a phosphodiesterase 4D inhibitor, induces weight and fat mass loss in aged mice without changing lean mass, physical and cognitive function.
Ijeoma M Muo, Sung-Jun Park, Antoine Smith, Danielle A Springer, Michele D Allen, Timothy J Hagen

Biochem Biophys Res Commun· December 2018

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The identification of inhibitory compounds of Rickettsia prowazekii methionine aminopeptidase for antibacterial applications.
Travis R Helgren, Elif S Seven, Congling Chen, Thomas E Edwards, Bart L Staker, Timothy J Hagen

Bioorg Med Chem Lett· May 2018

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()-4-Chloro--{3-[(4-chlorophenyl)sulfonyl]-2,3-dihydrobenzo[]thiazol-2-ylidene}benzene-sulfonamide.
Sydney M Watkins, Timothy J Hagen, Timothy S Perkins, Chong Zheng

IUCrdata· June 2017

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Demonstration of AutoDock as an Educational Tool for Drug Discovery.
Travis R Helgren, Timothy J Hagen

J Chem Educ· March 2017

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Rickettsia prowazekii methionine aminopeptidase as a promising target for the development of antibacterial agents.
Travis R Helgren, Congling Chen, Phumvadee Wangtrakuldee, Thomas E Edwards, Bart L Staker, Timothy J Hagen

Bioorg Med Chem· February 2017

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Synthesis and biological evaluation of pyrazolopyrimidines as potential antibacterial agents.
Gashaw M Goshu, Debarati Ghose, Joy M Bain, Phillip G Pierce, Darren W Begley, Timothy J Hagen

Bioorg Med Chem Lett· December 2015

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