Publications by authors named "Timothy Heffernan"

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KRAS Inhibition Activates an Actionable CD24 "Do Not Eat Me" Signal in Pancreatic Cancer.
Yongkun Wei, Minghui Liu, Er-Yen Yen, Jun Yao, Zhenzhen Xun, Timothy P Heffernan

Cancer Res· December 2025

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Nivolumab plus ipilimumab induce hyper-progression in renal medullary carcinoma: results of a phase II trial and preclinical evidence.
Melinda Soeung, Xinmiao Yan, Ciro Zanca, Jing Qian, Menuka Karki, Timothy Heffernan

Nat Commun· November 2025

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KRAS Inhibition Activates an Actionable CD24 "Don't Eat Me" Signal in Pancreatic Cancer.
Yongkun Wei, Minghui Liu, Er-Yen Yen, Jun Yao, Zhenzhen Xun, Timothy P Heffernan

bioRxiv· September 2025

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Distinct small molecule inhibitors of Kras specifically prime CTLA4 blockade therapy to transcriptionally reprogram Tregs and overcome resistance to suppress pancreas cancer.
Krishnan K Mahadevan, Ana S Maldonado, Bingrui Li, Aaron A Bickert, Adrian Kapercyzk-Perdyan, Timothy P Heffernan

bioRxiv· September 2025

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An allele-agnostic mutant-KRAS inhibitor suppresses tumor maintenance signals and reprograms tumor immunity in pancreatic cancer.
Kathleen M McAndrews, Francesca Paradiso, Clint A Stalnecker, Benson S Chellakkan, Fredrik I Thege, Timothy P Heffernan

Sci Transl Med· September 2025

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CDK8 remodels the tumor microenvironment to resist the therapeutic efficacy of targeted KRAS inhibition in pancreatic ductal adenocarcinoma.
Kathleen M McAndrews, Krishnan K Mahadevan, Bingrui Li, Amari M Sockwell, Sami J Morse, Timothy P Heffernan

bioRxiv· July 2025

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Evolutionary fingerprints of epithelial-to-mesenchymal transition.
Luigi Perelli, Li Zhang, Sarah Mangiameli, Francesca Giannese, Krishnan K Mahadevan, Timothy P Heffernan

Nature· April 2025

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Advocating for change-Integration of efforts across the drug discovery and development continuum.
Timothy P Heffernan, Giulio F Draetta

Cancer Cell· April 2025

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Is trauma isolating, or does isolation traumatize? Loneliness and posttraumatic stress mutually reinforce one another in the aftermath of environmental disaster.
Tegan Cruwys, Emily Macleod, Sonia Curll, Iain Walker, Tim Kurz, Timothy Heffernan

Psychol Trauma· March 2025

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Discovery of ART0380, a Potent and Selective ATR Kinase Inhibitor Undergoing Phase 2 Clinical Studies for the Treatment of Advanced or Metastatic Solid Cancers.
Christopher L Carroll, Michael G Johnson, Yanbing Ding, Zhijun Kang, R S K Vijayan, Timothy Heffernan

J Med Chem· December 2024

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A TRAILR2/CDH3 bispecific antibody demonstrates selective apoptosis and tumor regression in CDH3-positive pancreatic cancer.
Peter Jung, Stefan P Glaser, Jing Han, Alexandra Popa, Laura Pisarsky, Timothy P Heffernan

MAbs· December 2024

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Mechanisms of Resistance to Oncogenic KRAS Inhibition in Pancreatic Cancer.
Julien Dilly, Megan T Hoffman, Laleh Abbassi, Ziyue Li, Francesca Paradiso, Timothy P Heffernan

Cancer Discov· November 2024

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Co-targeting SOS1 enhances the antitumor effects of KRAS inhibitors by addressing intrinsic and acquired resistance.
Venu Thatikonda, Hengyu Lyu, Sabine Jurado, Kaja Kostyrko, Christopher A Bristow, Timothy P Heffernan

Nat Cancer· September 2024

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Social group connections support mental health following wildfire.
Tegan Cruwys, Emily Macleod, Timothy Heffernan, Iain Walker, Samantha K Stanley

Soc Psychiatry Psychiatr Epidemiol· June 2024

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Ataxia-Telangiectasia Mutated Loss-of-Function Displays Variant and Tissue-Specific Differences across Tumor Types.
Patrick G Pilié, Virginia Giuliani, Wei-Lien Wang, Daniel J McGrail, Christopher A Bristow, Timothy P Heffernan

Clin Cancer Res· May 2024

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The Brief Solastalgia Scale: A Psychometric Evaluation and Revision.
Bruce K Christensen, Conal Monaghan, Samantha K Stanley, Iain Walker, Zoe Leviston, Timothy Heffernan

Ecohealth· March 2024

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Clonal dominance defines metastatic dissemination in pancreatic cancer.
I-Lin Ho, Chieh-Yuan Li, Fuchenchu Wang, Li Zhao, Jingjing Liu, Timothy Heffernan

Sci Adv· March 2024

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Predictors of individual mental health and psychological resilience after Australia's 2019-2020 bushfires.
Emily Macleod, Timothy Heffernan, Lisa-Marie Greenwood, Iain Walker, Jo Lane

Aust N Z J Psychiatry· January 2024

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Correction: Preclinical development of 1B7/CD3, a novel anti-TSLPR bispecific antibody that targets CRLF2-rearranged Ph-like B-ALL.
Ze Tian, Chunhua Shi, Guojun Yang, Jason K Allen, Qing Shi, Timothy Heffernan

Leukemia· January 2024

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Preclinical development of 1B7/CD3, a novel anti-TSLPR bispecific antibody that targets CRLF2-rearranged Ph-like B-ALL.
Ze Tian, Chunhua Shi, Guojun Yang, Jason K Allen, Qing Shi, Timothy Heffernan

Leukemia· October 2023

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KRAS inhibition reprograms the microenvironment of early and advanced pancreatic cancer to promote FAS-mediated killing by CD8 T cells.
Krishnan K Mahadevan, Kathleen M McAndrews, Valerie S LeBleu, Sujuan Yang, Hengyu Lyu, Timothy P Heffernan

Cancer Cell· September 2023

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Evolutionary fingerprints of EMT in pancreatic cancers.
Luigi Perelli, Li Zhang, Sarah Mangiameli, Andrew J C Russell, Francesca Giannese, Timothy P Heffernan

bioRxiv· September 2023

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Interferon signaling promotes tolerance to chromosomal instability during metastatic evolution in renal cancer.
Luigi Perelli, Federica Carbone, Li Zhang, Justin K Huang, Courtney Le, Timothy P Heffernan

Nat Cancer· July 2023

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SMARCB1 regulates the hypoxic stress response in sickle cell trait.
Melinda Soeung, Luigi Perelli, Ziheng Chen, Eleonora Dondossola, I-Lin Ho, Timothy P Heffernan

Proc Natl Acad Sci U S A· May 2023

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Neddylation inhibition sensitises renal medullary carcinoma tumours to platinum chemotherapy.
Daniel D Shapiro, Niki Millward Zacharias, Durga N Tripathi, Menuka Karki, Jean-Philippe Bertocchio, Timothy P Heffernan

Clin Transl Med· May 2023

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