Publications by authors named "Timothy Hickling"

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Proceedings of the 15 European immunogenicity platform open symposium on immunogenicity of biopharmaceuticals.
Sophie Tourdot, Karien Bloem, Lysie Champion, Anne S De Groot, Axel Ducret, Timothy Hickling

MAbs· December 2025

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Comparable immunogenicity of new modality biotherapeutics delivered subcutaneously or intravenously in non-human primates.
Victoria Koch, Martin Lechmann, Katharine Bray-French, Matthias Füth, Elisabeth Husar, Timothy Hickling

J Immunotoxicol· December 2025

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Current regulatory requirements for assessment of immunogenicity for gene therapy medicinal products.
Christopher J Mann, Jon Giblin, Manuela Braun, Felicitas Schmid, Maria Rathmann Sørensen, Timothy P Hickling

Cell Rep Med· December 2025

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HLAIIPred: cross-attention mechanism for modeling the interaction of HLA class II molecules with peptides.
Mojtaba Haghighatlari, Nicholas Marze, Robert Seward, Andrew Ciarla, Rachel Hindin, Timothy P Hickling

Commun Biol· July 2025

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Elucidation of B-cell specific drug immunogenicity liabilities via a novel assay.
Cary M Looney, Axel Ducret, Guido Steiner, Karen Dernick, Katharina Hartman, Timothy Hickling

Front Immunol· June 2025

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Development and characterization of dendritic cell internalization and activation assays contributing to the immunogenicity risk evaluation of biotherapeutics.
Michel Siegel, Aman Padamsey, Anna-Lena Bolender, Patrick Hargreaves, Johannes Fraidling, Timothy P Hickling

Front Immunol· September 2024

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Internalization of therapeutic antibodies into dendritic cells as a risk factor for immunogenicity.
Michel Siegel, Anna-Lena Bolender, Axel Ducret, Johannes Fraidling, Katharina Hartman, Timothy P Hickling

Front Immunol· September 2024

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Expanding the MAPPs Assay to Accommodate MHC-II Pan Receptors for Improved Predictability of Potential T Cell Epitopes.
Katharina Hartman, Guido Steiner, Michel Siegel, Cary M Looney, Timothy P Hickling

Biology (Basel)· September 2023

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Validation of a Dendritic Cell and CD4+ T Cell Restimulation Assay Contributing to the Immunogenicity Risk Evaluation of Biotherapeutics.
Michel Siegel, Guido Steiner, Linnea C Franssen, Francesca Carratu, James Herron, Timothy P Hickling

Pharmaceutics· December 2022

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HLAII peptide presentation of infliximab increases when complexed with TNF.
Andrea Casasola-LaMacchia, Robert Joseph Seward, Sophie Tourdot, Matthew Willetts, Gary Kruppa, Timothy P Hickling

Front Immunol· October 2022

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Crystal structure of ultra-humanized anti-pTau Fab reveals how germline substitutions humanize CDRs without loss of binding'.
Alette R Brinth, Kristine Svenson, Lidia Mosyak, Orla Cunningham, Timothy Hickling

Sci Rep· May 2022

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Assay format diversity in pre-clinical immunogenicity risk assessment: Toward a possible harmonization of antigenicity assays.
Axel Ducret, Chloé Ackaert, Juliana Bessa, Campbell Bunce, Timothy Hickling

MAbs· March 2022

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Genome-wide pharmacogenetics of anti-drug antibody response to bococizumab highlights key residues in HLA DRB1 and DQB1.
Daniel I Chasman, Craig L Hyde, Franco Giulianini, Rebecca D Danning, Ellen Q Wang, Timothy Hickling

Sci Rep· March 2022

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Clinicogenomic factors of biotherapy immunogenicity in autoimmune disease: A prospective multicohort study of the ABIRISK consortium.
Signe Hässler, Delphine Bachelet, Julianne Duhaze, Natacha Szely, Aude Gleizes, Timothy P Hickling

PLoS Med· October 2020

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Correction to: Immunogenicity of Biosimilars for Rheumatic Diseases, Plaque Psoriasis, and Inflammatory Bowel Disease: A Review from Clinical Trials and Regulatory Documents.
Vibeke Strand, Joao Gonçalves, Timothy P Hickling, Heather E Jones, Lisa Marshall

BioDrugs· April 2020

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Immunogenicity of Biosimilars for Rheumatic Diseases, Plaque Psoriasis, and Inflammatory Bowel Disease: A Review from Clinical Trials and Regulatory Documents.
Vibeke Strand, Joao Gonçalves, Timothy P Hickling, Heather E Jones, Lisa Marshall

BioDrugs· February 2020

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A Quantitative Systems Pharmacology Consortium Approach to Managing Immunogenicity of Therapeutic Proteins.
Andrzej M Kierzek, Timothy P Hickling, Isabel Figueroa, J Cory Kalvass, Marjoleen Nijsen

CPT Pharmacometrics Syst Pharmacol· November 2019

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Nonclinical immunogenicity risk assessment of therapeutic proteins.
Sophie Tourdot, Timothy P Hickling

Bioanalysis· September 2019

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Recruiting the Immune System Against Disease: Lessons for Clinical and Systems Pharmacology.
Paolo Vicini, Nathan Standifer, Timothy P Hickling

CPT Pharmacometrics Syst Pharmacol· July 2019

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Immunogenicity of immunomodulatory, antibody-based, oncology therapeutics.
Jasmine Davda, Paul Declerck, Siwen Hu-Lieskovan, Timothy P Hickling, Ira A Jacobs

J Immunother Cancer· April 2019

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Importance of Feedback and Feedforward Loops to Adaptive Immune Response Modeling.
Anisur Rahman, Abhinav Tiwari, Jatin Narula, Timothy Hickling

CPT Pharmacometrics Syst Pharmacol· October 2018

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The Role of Aggregates of Therapeutic Protein Products in Immunogenicity: An Evaluation by Mathematical Modeling.
Liusong Yin, Xiaoying Chen, Abhinav Tiwari, Paolo Vicini, Timothy P Hickling

J Immunol Res· September 2016

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Comparing the immunogenicity of the etanercept biosimilar SB4 with the innovator etanercept: another consideration.
Lisa Marshall, Timothy Hickling, David Bill, Ehab Mahgoub

Ann Rheum Dis· July 2016

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Augmented Binary Substitution: Single-pass CDR germ-lining and stabilization of therapeutic antibodies.
Sue Townsend, Brian J Fennell, James R Apgar, Matthew Lambert, Barry McDonnell, Timothy P Hickling

Proc Natl Acad Sci U S A· December 2015

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Therapeutic outcomes, assessments, risk factors and mitigation efforts of immunogenicity of therapeutic protein products.
Liusong Yin, Xiaoying Chen, Paolo Vicini, Bonita Rup, Timothy P Hickling

Cell Immunol· June 2015

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