Publications by authors named "Timothy I M Tree"

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Blood samples collected under anesthesia can be used as a source of non-diseased controls for immune-based assays.
Clara Domingo-Vila, Evangelia D Williams, Megan E Smithmyer, Basilin Benson, Lauric A Ferrat, Timothy I M Tree

Front Immunol· August 2025

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Clonal driver neoantigen loss under EGFR TKI and immune selection pressures.
Maise Al Bakir, James L Reading, Samuel Gamble, Rachel Rosenthal, Imran Uddin, Timothy I M Tree

Nature· March 2025

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Ustekinumab for type 1 diabetes in adolescents: a multicenter, double-blind, randomized phase 2 trial.
Danijela Tatovic, Ashish Marwaha, Peter Taylor, Stephanie J Hanna, Kym Carter, Timothy I M Tree

Nat Med· September 2024

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Single-cell RNAseq identifies clonally expanded antigen-specific T-cells following intradermal injection of gold nanoparticles loaded with diabetes autoantigen in humans.
Stephanie J Hanna, Terri C Thayer, Emma J S Robinson, Ngoc-Nga Vinh, Nigel Williams, Timothy I M Tree

Front Immunol· November 2023

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Monitoring islet specific immune responses in type 1 diabetes clinical immunotherapy trials.
Sefina Arif, Clara Domingo-Vila, Emily Pollock, Eleni Christakou, Evangelia Williams, Timothy I M Tree

Front Immunol· June 2023

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Low-dose IL-2 reduces IL-21 T cell frequency and induces anti-inflammatory gene expression in type 1 diabetes.
Jia-Yuan Zhang, Fiona Hamey, Dominik Trzupek, Marius Mickunas, Mercede Lee, Timothy I M Tree

Nat Commun· November 2022

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Guidelines for standardizing T-cell cytometry assays to link biomarkers, mechanisms, and disease outcomes in type 1 diabetes.
Jennie H M Yang, Kirsten A Ward-Hartstonge, Daniel J Perry, J Lori Blanchfield, Amanda L Posgai, Timothy I M Tree

Eur J Immunol· March 2022

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Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition).
Andrea Cossarizza, Hyun-Dong Chang, Andreas Radbruch, Sergio Abrignani, Richard Addo, Timothy I M Tree

Eur J Immunol· December 2021

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A phase 1b open-label dose-finding study of ustekinumab in young adults with type 1 diabetes.
Ashish K Marwaha, Samuel Chow, Anne M Pesenacker, Laura Cook, Annika Sun, Timothy I M Tree

Immunother Adv· November 2021

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The effect of methotrexate and targeted immunosuppression on humoral and cellular immune responses to the COVID-19 vaccine BNT162b2: a cohort study.
Satveer K Mahil, Katie Bechman, Antony Raharja, Clara Domingo-Vila, David Baudry, Timothy I M Tree

Lancet Rheumatol· September 2021

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Autoreactive T cell profiles are altered following allogeneic islet transplantation with alemtuzumab induction and re-emerging phenotype is associated with graft function.
Shereen Sabbah, Aaron Liew, Augustin M Brooks, Rhiannon Kundu, James L Reading, Timothy I M Tree

Am J Transplant· March 2021

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Type 1 diabetes can present before the age of 6 months and is characterised by autoimmunity and rapid loss of beta cells.
Matthew B Johnson, Kashyap A Patel, Elisa De Franco, William Hagopian, Michael Killian, Timothy I M Tree

Diabetologia· December 2020

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Phenotypic Analysis of Human Lymph Nodes in Subjects With New-Onset Type 1 Diabetes and Healthy Individuals by Flow Cytometry.
Jennie H M Yang, Leena Khatri, Marius Mickunas, Evangelia Williams, Danijela Tatovic, Timothy I M Tree

Front Immunol· October 2020

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Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition).
Andrea Cossarizza, Hyun-Dong Chang, Andreas Radbruch, Andreas Acs, Dieter Adam, Timothy I M Tree

Eur J Immunol· October 2019

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Multipotent Adult Progenitor Cells Suppress T Cell Activation in Models of Homeostatic Proliferation in a Prostaglandin E2-Dependent Manner.
Fiona Carty, Jennifer M Corbett, João Paulo M C M Cunha, James L Reading, Timothy I M Tree

Front Immunol· June 2019

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Regulatory T cell dysfunction in type 1 diabetes: what's broken and how can we fix it?
Caroline M Hull, Mark Peakman, Timothy I M Tree

Diabetologia· October 2017

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Metabolic and immune effects of immunotherapy with proinsulin peptide in human new-onset type 1 diabetes.
Mohammad Alhadj Ali, Yuk-Fun Liu, Sefina Arif, Danijela Tatovic, Hina Shariff, Timothy I M Tree

Sci Transl Med· August 2017

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IL-2 therapy restores regulatory T-cell dysfunction induced by calcineurin inhibitors.
Gavin Whitehouse, Elizabeth Gray, Sotiris Mastoridis, Elliot Merritt, Elisavet Kodela, Timothy I M Tree

Proc Natl Acad Sci U S A· July 2017

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Generation of human islet-specific regulatory T cells by TCR gene transfer.
Caroline M Hull, Lauren E Nickolay, Megan Estorninho, Max W Richardson, James L Riley, Timothy I M Tree

J Autoimmun· May 2017

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Suppression of IL-7-dependent Effector T-cell Expansion by Multipotent Adult Progenitor Cells and PGE2.
James L Reading, Bart Vaes, Caroline Hull, Shereen Sabbah, Thomas Hayday, Timothy I M Tree

Mol Ther· November 2015

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Natural Variation in Interleukin-2 Sensitivity Influences Regulatory T-Cell Frequency and Function in Individuals With Long-standing Type 1 Diabetes.
Jennie H M Yang, Antony J Cutler, Ricardo C Ferreira, James L Reading, Nicholas J Cooper, Timothy I M Tree

Diabetes· November 2015

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Phenotypic Complexity of the Human Regulatory T Cell Compartment Revealed by Mass Cytometry.
Gavin M Mason, Katie Lowe, Rossella Melchiotti, Richard Ellis, Emanuele de Rinaldis, Timothy I M Tree

J Immunol· September 2015

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Immune modulation in humans: implications for type 1 diabetes mellitus.
Bart O Roep, Timothy I M Tree

Nat Rev Endocrinol· April 2014

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Clinical-grade multipotent adult progenitor cells durably control pathogenic T cell responses in human models of transplantation and autoimmunity.
James L Reading, Jennie H M Yang, Shereen Sabbah, Ania Skowera, Robin R Knight, Timothy I M Tree

J Immunol· May 2013

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Postthymic expansion in human CD4 naive T cells defined by expression of functional high-affinity IL-2 receptors.
Marcin L Pekalski, Ricardo C Ferreira, Richard M R Coulson, Antony J Cutler, Hui Guo, Timothy I M Tree

J Immunol· March 2013

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