Publications by authors named "Timothy J Knowles"

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HDAC6-dependent deacetylation of SAE2 enhances SUMO1 conjugation for mitotic integrity.
Alexander J Lanz, Alexandra K Walker, Mohammed Jamshad, Alexander J Garvin, Matthew Stewart, Timothy J Knowles

EMBO J· October 2025

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A porin-like protein used by bacterial predators defines a wider lipid-trapping superfamily.
Rebecca J Parr, Yoann G Santin, Giedrė Ratkevičiūte, Simon G Caulton, Paul Radford, Timothy J Knowles

Nat Commun· July 2025

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Distance tuneable integral membrane protein containing floating bilayers directed self-assembly.
Stephen C L Hall, David J Hardy, Éilís C Bragginton, Hannah Johnston, Tudor Onose, Timothy J Knowles

Nanoscale· July 2024

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Structure of the MlaC-MlaD complex reveals molecular basis of periplasmic phospholipid transport.
Peter Wotherspoon, Hannah Johnston, David J Hardy, Rachel Holyfield, Soi Bui, Timothy J Knowles

Nat Commun· July 2024

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The vaccinia chondroitin sulfate binding protein drives host membrane curvature to facilitate fusion.
Laura Pokorny, Jemima J Burden, David Albrecht, Rebecca Bamford, Kendra E Leigh, Timothy J Knowles

EMBO Rep· March 2024

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An octameric PqiC toroid stabilises the outer-membrane interaction of the PqiABC transport system.
Benjamin F Cooper, Giedrė Ratkevičiūtė, Luke A Clifton, Hannah Johnston, Rachel Holyfield, Timothy J Knowles

EMBO Rep· January 2024

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Peptidoglycan maturation controls outer membrane protein assembly.
Gideon Mamou, Federico Corona, Ruth Cohen-Khait, Nicholas G Housden, Vivian Yeung, Timothy J Knowles

Nature· June 2022

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The lipoprotein DolP affects cell separation in , but not as an upstream regulator of NlpD.
Gabriela Boelter, Jack A Bryant, Hannah Doherty, Peter Wotherspoon, Dema Alodaini, Timothy J Knowles

Microbiology (Reading)· May 2022

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Surface-tethered planar membranes containing the β-barrel assembly machinery: a platform for investigating bacterial outer membrane protein folding.
Stephen C L Hall, Luke A Clifton, Pooja Sridhar, David J Hardy, Peter Wotherspoon, Timothy J Knowles

Biophys J· December 2021

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Methods for the solubilisation of membrane proteins: the micelle-aneous world of membrane protein solubilisation.
Giedre Ratkeviciute, Benjamin F Cooper, Timothy J Knowles

Biochem Soc Trans· August 2021

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Structure of dual BON-domain protein DolP identifies phospholipid binding as a new mechanism for protein localisation.
Jack Alfred Bryant, Faye C Morris, Timothy J Knowles, Riyaz Maderbocus, Eva Heinz

Elife· December 2020

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Adsorption of a styrene maleic acid (SMA) copolymer-stabilized phospholipid nanodisc on a solid-supported planar lipid bilayer.
Stephen C L Hall, Luke A Clifton, Cecilia Tognoloni, Kerrie A Morrison, Timothy J Knowles

J Colloid Interface Sci· August 2020

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Structural Investigations of Protein-Lipid Complexes Using Neutron Scattering.
Luke A Clifton, Stephen C L Hall, Najet Mahmoudi, Timothy J Knowles, Frank Heinrich

Methods Mol Biol· March 2020

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Butyrophilin-2A1 Directly Binds Germline-Encoded Regions of the Vγ9Vδ2 TCR and Is Essential for Phosphoantigen Sensing.
Mohindar M Karunakaran, Carrie R Willcox, Mahboob Salim, Daniel Paletta, Alina S Fichtner, Timothy J Knowles

Immunity· March 2020

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Evidence for phospholipid export from the bacterial inner membrane by the Mla ABC transport system.
Gareth W Hughes, Stephen C L Hall, Claire S Laxton, Pooja Sridhar, Amirul H Mahadi, Timothy J Knowles

Nat Microbiol· October 2019

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SMA-PAGE: A new method to examine complexes of membrane proteins using SMALP nano-encapsulation and native gel electrophoresis.
Naomi L Pollock, Megha Rai, Kailene S Simon, Sophie J Hesketh, Alvin C K Teo, Timothy J Knowles

Biochim Biophys Acta Biomembr· August 2019

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The C-terminal tail of the bacterial translocation ATPase SecA modulates its activity.
Mohammed Jamshad, Timothy J Knowles, Scott A White, Douglas G Ward, Fiyaz Mohammed

Elife· June 2019

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YraP Contributes to Cell Envelope Integrity and Virulence of Salmonella enterica Serovar Typhimurium.
Faye C Morris, Timothy J Wells, Jack A Bryant, Anna E Schager, Yanina R Sevastsyanovich, Timothy J Knowles

Infect Immun· November 2018

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Minichaperone (GroEL191-345) mediated folding of MalZ proceeds by binding and release of native and functional intermediates.
Neha Jain, Timothy J Knowles, Peter A Lund, Tapan K Chaudhuri

Biochim Biophys Acta Proteins Proteom· September 2018

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An acid-compatible co-polymer for the solubilization of membranes and proteins into lipid bilayer-containing nanoparticles.
Stephen C L Hall, Cecilia Tognoloni, Jack Charlton, Éilís C Bragginton, Alice J Rothnie, Timothy J Knowles

Nanoscale· June 2018

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BTN3A1 Discriminates γδ T Cell Phosphoantigens from Nonantigenic Small Molecules via a Conformational Sensor in Its B30.2 Domain.
Mahboob Salim, Timothy J Knowles, Alfie T Baker, Martin S Davey, Mark Jeeves

ACS Chem Biol· October 2017

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MCE domain proteins: conserved inner membrane lipid-binding proteins required for outer membrane homeostasis.
Georgia L Isom, Nathaniel J Davies, Zhi-Soon Chong, Jack A Bryant, Mohammed Jamshad, Timothy J Knowles

Sci Rep· August 2017

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Expression, Purification, and Screening of BamE, a Component of the BAM Complex, for Structural Characterization.
Mark Jeeves, Pooja Sridhar, Timothy J Knowles

Methods Mol Biol· July 2016

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Characterization of a Putative Receptor Binding Surface on Skint-1, a Critical Determinant of Dendritic Epidermal T Cell Selection.
Mahboob Salim, Timothy J Knowles, Rosie Hart, Fiyaz Mohammed, Martin J Woodward

J Biol Chem· April 2016

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Mechanism of intermediate filament recognition by plakin repeat domains revealed by envoplakin targeting of vimentin.
Claudia Fogl, Fiyaz Mohammed, Caezar Al-Jassar, Mark Jeeves, Timothy J Knowles

Nat Commun· March 2016

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