Publications by authors named "Timothy J Snape"

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Tubulin targeting agents and their implications in non-cancer disease management.
Samridhi Lal, Timothy J Snape

Drug Discov Today· April 2025

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2,3-Diarylindoles as COX-2 Inhibitors: Exploring the Structure-activity Relationship through Molecular Docking Simulations.
Andrea Cuppoloni, João Vitor Silva, Timothy James Snape, Samridhi Lal, Jeanine Giarolla

Curr Top Med Chem· July 2023

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Hydroxy-xanthones as promising antiviral agents: Synthesis and biological evaluation against human coronavirus OC43.
Bethanie Dean, Gemma Cooper, Maitreyi Shivkumar, Timothy J Snape

Bioorg Med Chem Lett· March 2023

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Novel diarylamides and diarylureas with N-substitution dependent activity against medulloblastoma.
Christopher Lawson, Thowaiba Babikr Ahmed Alta, Georgia Moschou, Vasiliki Skamnaki, Theodora G A Solovou, Timothy J Snape

Eur J Med Chem· December 2021

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Linearized esculentin-2EM shows pH dependent antibacterial activity with an alkaline optimum.
Erum Malik, David A Phoenix, Timothy J Snape, Frederick Harris, Jaipaul Singh

Mol Cell Biochem· October 2021

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A therapeutic update on PARP inhibitors: implications in the treatment of glioma.
Samridhi Lal, Timothy J Snape

Drug Discov Today· February 2021

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Synthetic flavonoid derivatives targeting the glycogen phosphorylase inhibitor site: QM/MM-PBSA motivated synthesis of substituted 5,7-dihydroxyflavones, crystallography, in vitro kinetics and ex-vivo cellular experiments reveal novel potent inhibitors.
Ben A Chetter, Efthimios Kyriakis, Daniel Barr, Aikaterini G Karra, Elisabeth Katsidou, Timothy J Snape

Bioorg Chem· September 2020

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Biophysical studies on the antimicrobial activity of linearized esculentin 2EM.
Erum Malik, David A Phoenix, Kamal Badiani, Timothy J Snape, Frederick Harris

Biochim Biophys Acta Biomembr· February 2020

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Identification of -β-d-Glucopyranosyl Azole-Type Inhibitors of Glycogen Phosphorylase That Reduce Glycogenolysis in Hepatocytes: Design, Synthesis, Kinetics, and Studies.
Daniel Barr, Eszter Szennyes, Éva Bokor, Ziad H Al-Oanzi, Colin Moffatt, Timothy J Snape

ACS Chem Biol· July 2019

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Towards identifying potent new hits for glioblastoma.
Chris Sherer, Saurabh Prabhu, David Adams, Joseph Hayes, Farzana Rowther, Timothy J Snape

Medchemcomm· November 2018

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Preliminary SAR on indole-3-carbinol and related fragments reveals a novel anticancer lead compound against resistant glioblastoma cells.
Christopher Sherer, Ibrahim Tolaymat, Farzana Rowther, Tracy Warr, Timothy J Snape

Bioorg Med Chem Lett· April 2017

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Anionic Host Defence Peptides from the Plant Kingdom: Their Anticancer Activity and Mechanisms of Action.
Frederick Harris, Saurabh Prabhu, Sarah R Dennison, Timothy J Snape, Robert Lea

Protein Pept Lett· March 2017

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Functional foldamers that target bacterial membranes: The effect of charge, amphiphilicity and conformation.
Yogita Patil-Sen, Sarah R Dennison, Timothy J Snape

Bioorg Med Chem· September 2016

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Foldamers as Anticancer Therapeutics: Targeting Protein-Protein Interactions and the Cell Membrane.
Sara Fahs, Yogita Patil-Sen, Timothy J Snape

Chembiochem· September 2015

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Functionalising the azobenzene motif delivers a light-responsive membrane-interactive compound with the potential for photodynamic therapy applications.
Theodore J Hester, Sarah R Dennison, Matthew J Baker, Timothy J Snape

Org Biomol Chem· August 2015

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Heterocyclic scaffolds as promising anticancer agents against tumours of the central nervous system: Exploring the scope of indole and carbazole derivatives.
Chris Sherer, Timothy J Snape

Eur J Med Chem· June 2015

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Approaches toward improving the prognosis of pediatric patients with glioma: pursuing mutant drug targets with emerging small molecules.
Timothy J Snape, Tracy Warr

Semin Pediatr Neurol· March 2015

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Cn-AMP2 from green coconut water is an anionic anticancer peptide.
Saurabh Prabhu, Sarah R Dennison, Manuela Mura, Robert W Lea, Timothy J Snape

J Pept Sci· December 2014

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Aromatic amides and ureas as novel molecular probes for diagnosing disease.
Samridhi Lal, Timothy J Snape

Med Hypotheses· December 2014

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Small-molecule clinical trial candidates for the treatment of glioma.
Saurabh Prabhu, Frederick Harris, Robert Lea, Timothy J Snape

Drug Discov Today· September 2014

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Development of a novel, multifunctional, membrane-interactive pyridinium salt with potent anticancer activity.
Sara Fahs, Farjana B Rowther, Sarah R Dennison, Yogita Patil-Sen, Tracy Warr, Timothy J Snape

Bioorg Med Chem Lett· August 2014

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Synthetic oligoureas of metaphenylenediamine mimic host defence peptides in their antimicrobial behaviour.
Sarah R Dennison, David A Phoenix, Timothy J Snape

Bioorg Med Chem Lett· May 2013

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Thermodynamic interactions of a cis and trans benzanilide with Escherichia coli bacterial membranes.
Sarah R Dennison, Timothy J Snape, David A Phoenix

Eur Biophys J· August 2012

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Towards a chemo-enzymatic method for the asymmetric synthesis of beta-amino tertiary alcohols.
Andrea March-Cortijos, Timothy J Snape

Org Biomol Chem· December 2009

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A truce on the Smiles rearrangement: revisiting an old reaction--the Truce-Smiles rearrangement.
Timothy J Snape

Chem Soc Rev· November 2008

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