Publications by authors named "Timothy Lezon"

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A Tutorial on the Development of a Physiologically Inspired PKRO Model for Monoclonal Antibodies.
Georgi I Kapitanov, David Flowers, Diana H Marcantonio, Timothy R Lezon, Josh F Apgar

CPT Pharmacometrics Syst Pharmacol· December 2025

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A high throughput, high content screen for non-toxic small molecules that reduce levels of the nuclear lamina protein, Lamin B1.
Laura L Vollmer, Fang Liu, Bruce Nmezi, Guillermo Rodriguez Bey, Nathan Herdman, Timothy R Lezon

Sci Rep· March 2025

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Predicting the Effects of Drug Combinations Using Probabilistic Matrix Factorization.
Ron Nafshi, Timothy R Lezon

Front Bioinform· August 2021

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Inhibition of RPS6K reveals context-dependent Akt activity in luminal breast cancer cells.
Cemal Erdem, Adrian V Lee, D Lansing Taylor, Timothy R Lezon

PLoS Comput Biol· June 2021

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Harnessing Human Microphysiology Systems as Key Experimental Models for Quantitative Systems Pharmacology.
D Lansing Taylor, Albert Gough, Mark E Schurdak, Lawrence Vernetti, Chakra S Chennubhotla, Timothy R Lezon

Handb Exp Pharmacol· January 2020

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A Quantitative Systems Pharmacology Approach to Infer Pathways Involved in Complex Disease Phenotypes.
Mark E Schurdak, Fen Pei, Timothy R Lezon, Diane Carlisle, Robert Friedlander

Methods Mol Biol· February 2019

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Connecting Neuronal Cell Protective Pathways and Drug Combinations in a Huntington's Disease Model through the Application of Quantitative Systems Pharmacology.
Fen Pei, Hongchun Li, Mark J Henderson, Steven A Titus, Ajit Jadhav, Timothy R Lezon

Sci Rep· December 2017

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Platform for Quantitative Evaluation of Spatial Intratumoral Heterogeneity in Multiplexed Fluorescence Images.
Daniel M Spagnolo, Yousef Al-Kofahi, Peihong Zhu, Timothy R Lezon, Albert Gough

Cancer Res· November 2017

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Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release.
Yalikun Suofu, Wei Li, Frédéric G Jean-Alphonse, Jiaoying Jia, Nicolas K Khattar, Timothy R Lezon

Proc Natl Acad Sci U S A· September 2017

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Biologically Relevant Heterogeneity: Metrics and Practical Insights.
Albert Gough, Andrew M Stern, John Maier, Timothy Lezon, Tong-Ying Shun

SLAS Discov· March 2017

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Modeling global changes induced by local perturbations to the HIV-1 capsid.
Shana Bergman, Timothy R Lezon

J Mol Graph Model· January 2017

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Pointwise mutual information quantifies intratumor heterogeneity in tissue sections labeled with multiple fluorescent biomarkers.
Daniel M Spagnolo, Rekha Gyanchandani, Yousef Al-Kofahi, Andrew M Stern, Timothy R Lezon

J Pathol Inform· November 2016

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Proteomic Screening and Lasso Regression Reveal Differential Signaling in Insulin and Insulin-like Growth Factor I (IGF1) Pathways.
Cemal Erdem, Alison M Nagle, Angelo J Casa, Beate C Litzenburger, Yu-Fen Wang, Timothy R Lezon

Mol Cell Proteomics· September 2016

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Identifying and quantifying heterogeneity in high content analysis: application of heterogeneity indices to drug discovery.
Albert H Gough, Ning Chen, Tong Ying Shun, Timothy R Lezon, Robert C Boltz

PLoS One· November 2015

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Evol and ProDy for bridging protein sequence evolution and structural dynamics.
Ahmet Bakan, Anindita Dutta, Wenzhi Mao, Ying Liu, Chakra Chennubhotla, Timothy R Lezon

Bioinformatics· September 2014

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The effects of rigid motions on elastic network model force constants.
Timothy R Lezon

Proteins· April 2012

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Constraints imposed by the membrane selectively guide the alternating access dynamics of the glutamate transporter GltPh.
Timothy R Lezon, Ivet Bahar

Biophys J· March 2012

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Global dynamics of proteins: bridging between structure and function.
Ivet Bahar, Timothy R Lezon, Lee-Wei Yang, Eran Eyal

Annu Rev Biophys· July 2010

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Using entropy maximization to understand the determinants of structural dynamics beyond native contact topology.
Timothy R Lezon, Ivet Bahar

PLoS Comput Biol· June 2010

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Normal mode analysis of biomolecular structures: functional mechanisms of membrane proteins.
Ivet Bahar, Timothy R Lezon, Ahmet Bakan, Indira H Shrivastava

Chem Rev· March 2010

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Global motions of the nuclear pore complex: insights from elastic network models.
Timothy R Lezon, Andrej Sali, Ivet Bahar

PLoS Comput Biol· September 2009

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Using the principle of entropy maximization to infer genetic interaction networks from gene expression patterns.
Timothy R Lezon, Jayanth R Banavar, Marek Cieplak, Amos Maritan, Nina V Fedoroff

Proc Natl Acad Sci U S A· December 2006

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What determines the spectrum of protein native state structures?
Timothy R Lezon, Jayanth R Banavar, Arthur M Lesk, Amos Maritan

Proteins· May 2006

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Geometry of proteins: hydrogen bonding, sterics, and marginally compact tubes.
Jayanth R Banavar, Marek Cieplak, Alessandro Flammini, Trinh X Hoang, Randall D Kamien, Timothy Lezon

Phys Rev E Stat Nonlin Soft Matter Phys· March 2006

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Recognition of coarse-grained protein tertiary structure.
Timothy Lezon, Jayanth R Banavar, Amos Maritan

Proteins· May 2004

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