Publications by authors named "Timothy Machajewski"

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Potent LpxC Inhibitors with Activity against Multidrug-Resistant Pseudomonas aeruginosa.
Kevin M Krause, Cat M Haglund, Christy Hebner, Alisa W Serio, Grace Lee, Timothy D Machajewski

Antimicrob Agents Chemother· November 2019

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Optimization of LpxC Inhibitors for Antibacterial Activity and Cardiovascular Safety.
Frederick Cohen, James B Aggen, Logan D Andrews, Zahra Assar, Jen Boggs, Timothy D Machajewski

ChemMedChem· August 2019

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Optimization and Mechanistic Characterization of Pyridopyrimidine Inhibitors of Bacterial Biotin Carboxylase.
Logan D Andrews, Timothy R Kane, Paola Dozzo, Cat M Haglund, Darin J Hilderbrandt, Timothy Machajewski

J Med Chem· August 2019

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Discovery of RAF265: A Potent mut-B-RAF Inhibitor for the Treatment of Metastatic Melanoma.
Teresa E Williams, Sharadha Subramanian, Joelle Verhagen, Christopher M McBride, Abran Costales, Timothy Machajewski

ACS Med Chem Lett· September 2015

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Design, structure-activity relationship, and in vivo characterization of the development candidate NVP-HSP990.
Christopher M McBride, Barry Levine, Yi Xia, Cornelia Bellamacina, Timothy Machajewski

J Med Chem· November 2014

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The novel oral Hsp90 inhibitor NVP-HSP990 exhibits potent and broad-spectrum antitumor activities in vitro and in vivo.
Daniel L Menezes, Pietro Taverna, Michael R Jensen, Tinya Abrams, Darrin Stuart, Timothy Machajewski

Mol Cancer Ther· March 2012

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Design, structure-activity relationships and in vivo characterization of 4-amino-3-benzimidazol-2-ylhydroquinolin-2-ones: a novel class of receptor tyrosine kinase inhibitors.
Paul A Renhowe, Sabina Pecchi, Cynthia M Shafer, Timothy D Machajewski, Elisa M Jazan

J Med Chem· January 2009

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One-pot synthesis of L-Fructose using coupled multienzyme systems based on rhamnulose-1-phosphate aldolase.
Dirk Franke, Timothy Machajewski, Che-Chang Hsu, Chi-Huey Wong

J Org Chem· August 2003

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