Publications by authors named "Timothy N Perkins"

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Disrupting intracellular RAGE signaling to combat pathological inflammation in disease.
Timothy N Perkins

Cell Chem Biol· October 2025

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Lung ILC2s are activated in BALB/c mice born to immunized mothers despite complete protection against respiratory syncytial virus.
Jessica L Kosanovich, Katherine M Eichinger, Madeline A Lipp, Sonal V Gidwani, Devarshi Brahmbhatt, Timothy N Perkins

Front Immunol· June 2024

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Exacerbated lung inflammation following secondary RSV exposure is CD4+ T cell-dependent and is not mitigated in infant BALB/c mice born to PreF-vaccinated dams.
Jessica L Kosanovich, Katherine M Eichinger, Madeline A Lipp, Sonal V Gidwani, Devarshi Brahmbhatt, Timothy N Perkins

Front Immunol· August 2023

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The AGE-RAGE Axis and the Pathophysiology of Multimorbidity in COPD.
Niki L Reynaert, Lowie E G W Vanfleteren, Timothy N Perkins

J Clin Med· May 2023

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RAGE contributes to allergen driven severe neutrophilic airway inflammation NLRP3 inflammasome activation in mice.
Katherine N Killian, Jessica L Kosanovich, Madeline A Lipp, Kerry M Empey, Tim D Oury, Timothy N Perkins

Front Immunol· February 2023

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Prior respiratory syncytial virus infection reduces vaccine-mediated Th2-skewed immunity, but retains enhanced RSV F-specific CD8 T cell responses elicited by a Th1-skewing vaccine formulation.
Katherine M Eichinger, Jessica L Kosanovich, Timothy N Perkins, Tim D Oury, Nikolai Petrovsky

Front Immunol· October 2022

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The perplexing role of RAGE in pulmonary fibrosis: causality or casualty?
Timothy N Perkins, Tim D Oury

Ther Adv Respir Dis· February 2022

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The axis of the receptor for advanced glycation endproducts in asthma and allergic airway disease.
Timothy N Perkins, Mason L Donnell, Tim D Oury

Allergy· May 2021

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Prefusion RSV F Immunization Elicits Th2-Mediated Lung Pathology in Mice When Formulated With a Th2 (but Not a Th1/Th2-Balanced) Adjuvant Despite Complete Viral Protection.
Katherine M Eichinger, Jessica L Kosanovich, Sonal V Gidwani, Aaron Zomback, Madeline A Lipp, Timothy N Perkins

Front Immunol· April 2021

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Maternal immunization with adjuvanted RSV prefusion F protein effectively protects offspring from RSV challenge and alters innate and T cell immunity.
Katherine M Eichinger, Jessica L Kosanovich, Madeline A Lipp, Timothy N Perkins, Nikolai Petrovsky

Vaccine· November 2020

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Formulation of the prefusion RSV F protein with a Th1/Th2-balanced adjuvant provides complete protection without Th2-skewed immunity in RSV-experienced young mice.
Jessica L Kosanovich, Katherine M Eichinger, Madeline A Lipp, Mark A Yondola, Timothy N Perkins

Vaccine· September 2020

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The receptor for advanced glycation end products is a critical mediator of type 2 cytokine signaling in the lungs.
Timothy N Perkins, Elizabeth A Oczypok, Regina E Dutz, Mason L Donnell, Michael M Myerburg

J Allergy Clin Immunol· September 2019

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Crystalline silica alters Sulfatase-1 expression in rat lungs which influences hyper-proliferative and fibrogenic effects in human lung epithelial cells.
Timothy N Perkins, Paul M Peeters, Catrin Albrecht, Roel P F Schins, Mieke A Dentener

Toxicol Appl Pharmacol· June 2018

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Alveolar Epithelial Cell-Derived Mediators: Potential Direct Regulators of Large Airway and Vascular Responses.
Elizabeth A Oczypok, Timothy N Perkins, Tim D Oury

Am J Respir Cell Mol Biol· June 2017

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All the "RAGE" in lung disease: The receptor for advanced glycation endproducts (RAGE) is a major mediator of pulmonary inflammatory responses.
Elizabeth A Oczypok, Timothy N Perkins, Tim D Oury

Paediatr Respir Rev· June 2017

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Alteration of canonical and non-canonical WNT-signaling by crystalline silica in human lung epithelial cells.
Timothy N Perkins, Mieke A Dentener, Frank R Stassen, Gernot G Rohde, Brooke T Mossman

Toxicol Appl Pharmacol· June 2016

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Indications for distinct pathogenic mechanisms of asbestos and silica through gene expression profiling of the response of lung epithelial cells.
Timothy N Perkins, Paul M Peeters, Arti Shukla, Ingrid Arijs, Julie Dragon

Hum Mol Genet· March 2015

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Extracellular signal-regulated kinase 5 and cyclic AMP response element binding protein are novel pathways inhibited by vandetanib (ZD6474) and doxorubicin in mesotheliomas.
Mutlay Sayan, Arti Shukla, Maximilian B MacPherson, Sherrill L Macura, Jedd M Hillegass, Timothy N Perkins

Am J Respir Cell Mol Biol· November 2014

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Silica-induced NLRP3 inflammasome activation in vitro and in rat lungs.
Paul M Peeters, Irene M J Eurlings, Timothy N Perkins, Emiel F Wouters, Roel P F Schins

Part Fibre Toxicol· November 2014

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Microspheres targeted with a mesothelin antibody and loaded with doxorubicin reduce tumor volume of human mesotheliomas in xenografts.
Sherrill L Macura, Jeremy L Steinbacher, Maximilian B Macpherson, Melissa J Lathrop, Mutlay Sayan, Timothy N Perkins

BMC Cancer· September 2013

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Asbestos and erionite prime and activate the NLRP3 inflammasome that stimulates autocrine cytokine release in human mesothelial cells.
Jedd M Hillegass, Jill M Miller, Maximilian B MacPherson, Catherine M Westbom, Mutlay Sayan, Timothy N Perkins

Part Fibre Toxicol· August 2013

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Silica induces NLRP3 inflammasome activation in human lung epithelial cells.
Paul M Peeters, Timothy N Perkins, Emiel F M Wouters, Brooke T Mossman, Niki L Reynaert

Part Fibre Toxicol· February 2013

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A multifunctional mesothelin antibody-tagged microparticle targets human mesotheliomas.
Sherrill L Macura, Jedd M Hillegass, Jeremy L Steinbacher, Maximilian B MacPherson, Arti Shukla, Timothy N Perkins

J Histochem Cytochem· September 2012

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Differences in gene expression and cytokine production by crystalline vs. amorphous silica in human lung epithelial cells.
Timothy N Perkins, Arti Shukla, Paul M Peeters, Jeremy L Steinbacher, Christopher C Landry

Part Fibre Toxicol· February 2012

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Mechanisms of oxidative stress and alterations in gene expression by Libby six-mix in human mesothelial cells.
Jedd M Hillegass, Arti Shukla, Maximilian B MacPherson, Sherrill A Lathrop, Vlada Alexeeva, Timothy N Perkins

Part Fibre Toxicol· September 2010

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