Publications by authors named "Timothy Nichols"

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Lack of factor VIII detection in humans and dogs with an intron 22 inversion challenges hypothesis regarding inhibitor risk.
Pooja Vir, Devi Gunasekera, Batsukh Dorjbal, Dennis McDaniel, Atul Agrawal, Timothy C Nichols

J Thromb Haemost· December 2024

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AAV gene therapy in companion dogs with severe hemophilia: Real-world long-term data on immunogenicity, efficacy, and quality of life.
Bhavya S Doshi, Benjamin J Samelson-Jones, Timothy C Nichols, Elizabeth P Merricks, Joshua L Siner

Mol Ther Methods Clin Dev· March 2024

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Lipid nanoparticles and siRNA targeting plasminogen provide lasting inhibition of fibrinolysis in mouse and dog models of hemophilia A.
Amy W Strilchuk, Woosuk S Hur, Paul Batty, Yaqiu Sang, Sara R Abrahams, Timothy C Nichols

Sci Transl Med· February 2024

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Analysis of vector genome integrations in multicentric lymphoma after AAV gene therapy in a severe hemophilia A dog.
Lucas Van Gorder, Bhavya S Doshi, Elinor Willis, Timothy C Nichols, Emma Cook

Mol Ther Methods Clin Dev· December 2023

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Recombinant von Willebrand factor and tranexamic acid for heavy menstrual bleeding in patients with mild and moderate von Willebrand disease in the USA (VWDMin): a phase 3, open-label, randomised, crossover trial.
Margaret V Ragni, Scott D Rothenberger, Robert Feldman, Danielle Nance, Andrew D Leavitt, Timothy C Nichols

Lancet Haematol· August 2023

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Mechanisms of Foreign Body Response Mitigation by Nitric Oxide Release.
James B Taylor, Maggie J Malone-Povolny, Elizabeth P Merricks, Lauren E Wimsey, Daniel Soliman, Timothy C Nichols

Int J Mol Sci· October 2022

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Adeno-associated virus-mediated expression of activated factor V (FVa) for hemophilia phenotypic correction.
Junjiang Sun, Xiaojing Chen, Zheng Chai, Hongqian Niu, Amanda L Dobbins, Timothy C Nichols

Front Med (Lausanne)· August 2022

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Intrinsic and acquired drug resistance to LSD1 inhibitors in small cell lung cancer occurs through a TEAD4-driven transcriptional state.
Wen Yan, Chi-Yeh Chung, Tao Xie, Mark Ozeck, Timothy C Nichols

Mol Oncol· March 2022

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Dexamethasone Transiently Enhances Transgene Expression in the Liver When Administered at Late-Phase Post Long-Term Adeno-Associated Virus Transduction.
Zheng Chai, Xintao Zhang, Amanda Lee Dobbins, Richard Jude Samulski, Elizabeth P Merricks, Timothy C Nichols

Hum Gene Ther· February 2022

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Chimeric Mice Engrafted With Canine Hepatocytes Exhibits Similar AAV Transduction Efficiency to Hemophilia B Dog.
Wenwei Shao, Junjiang Sun, Xiaojing Chen, Amanda Dobbins, Elizabeth P Merricks, Timothy C Nichols

Front Pharmacol· January 2022

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Combination of Nitric Oxide Release and Surface Texture for Mitigating the Foreign Body Response.
Maggie J Malone-Povolny, Taron M Bradshaw, Elizabeth P Merricks, C Tyler Long, Timothy C Nichols

ACS Biomater Sci Eng· June 2021

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Evolutionary insights into coagulation factor IX Padua and other high-specific-activity variants.
Benjamin J Samelson-Jones, Jonathan D Finn, Leslie J Raffini, Elizabeth P Merricks, Rodney M Camire, Timothy C Nichols

Blood Adv· March 2021

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A long-term study of AAV gene therapy in dogs with hemophilia A identifies clonal expansions of transduced liver cells.
Giang N Nguyen, John K Everett, Samita Kafle, Aoife M Roche, Hayley E Raymond, Timothy C Nichols

Nat Biotechnol· January 2021

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Preclinical evaluation of a next-generation, subcutaneously administered, coagulation factor IX variant, dalcinonacog alfa.
Timothy C Nichols, Howard Levy, Elizabeth P Merricks, Robin A Raymer, Martin L Lee

PLoS One· December 2020

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Development of AAV Variants with Human Hepatocyte Tropism and Neutralizing Antibody Escape Capacity.
Xiaolei Pei, Wenwei Shao, Allene Xing, Charles Askew, Xiaojing Chen, Timothy C Nichols

Mol Ther Methods Clin Dev· September 2020

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Superior human hepatocyte transduction with adeno-associated virus vector serotype 7.
Wenwei Shao, Xiaolei Pei, Caibin Cui, Charles Askew, Amanda Dobbins, Timothy C Nichols

Gene Ther· December 2019

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Long-Term Accurate Continuous Glucose Biosensors via Extended Nitric Oxide Release.
Maggie J Malone-Povolny, Elizabeth P Merricks, Lauren E Wimsey, Timothy C Nichols, Mark H Schoenfisch

ACS Sens· December 2019

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Coronary Artery Disease Risk-Associated Gene and Its Product Lipid Phosphate Phosphatase 3 Regulate Experimental Atherosclerosis.
Paul A Mueller, Liping Yang, Margo Ubele, Guogen Mao, Jason Brandon, Timothy C Nichols

Arterioscler Thromb Vasc Biol· November 2019

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Combining CDK4/6 inhibition with taxanes enhances anti-tumor efficacy by sustained impairment of pRB-E2F pathways in squamous cell lung cancer.
Joan Cao, Zhou Zhu, Hui Wang, Timothy C Nichols, Goldie Y L Lui

Oncogene· May 2019

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Mechanical Anisotropy Assessment in Kidney Cortex Using ARFI Peak Displacement: Preclinical Validation and Pilot In Vivo Clinical Results in Kidney Allografts.
Md Murad Hossain, Randal K Detwiler, Emily H Chang, Melissa C Caughey, Melrose W Fisher, Timothy C Nichols

IEEE Trans Ultrason Ferroelectr Freq Control· March 2019

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Delineation of Human Carotid Plaque Features In Vivo by Exploiting Displacement Variance.
Gabriela Torres, Tomasz J Czernuszewicz, Jonathon W Homeister, Melissa C Caughey, Benjamin Y Huang, Timothy C Nichols

IEEE Trans Ultrason Ferroelectr Freq Control· March 2019

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An Observational Study from Long-Term AAV Re-administration in Two Hemophilia Dogs.
Junjiang Sun, Wenwei Shao, Xiaojing Chen, Elizabeth P Merricks, Lauren Wimsey, Timothy C Nichols

Mol Ther Methods Clin Dev· September 2018

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Influence of diabetes on the foreign body response to nitric oxide-releasing implants.
Robert J Soto, Elizabeth P Merricks, Dwight A Bellinger, Timothy C Nichols, Mark H Schoenfisch

Biomaterials· March 2018

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Complete correction of hemophilia B phenotype by FIX-Padua skeletal muscle gene therapy in an inhibitor-prone dog model.
Robert A French, Benjamin J Samelson-Jones, Glenn P Niemeyer, Clinton D Lothrop, Elizabeth P Merricks, Timothy C Nichols

Blood Adv· March 2018

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Performance of acoustic radiation force impulse ultrasound imaging for carotid plaque characterization with histologic validation.
Tomasz J Czernuszewicz, Jonathon W Homeister, Melissa C Caughey, Yue Wang, Hongtu Zhu, Timothy C Nichols

J Vasc Surg· December 2017

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