Publications by authors named "Timothy Opperman"

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N-arylpyrimidinamine (NAPA) compounds are broadly acting inhibitors of human cytomegalovirus infection and spread.
Kristina E Atanasoff, Sabrina I Ophir, Andrea J Parsons, Jailene Paredes Casado, Nell S Lurain, Timothy J Opperman

Antiviral Res· January 2025

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Unsaturated fatty acid perturbation combats emerging triazole antifungal resistance in the human fungal pathogen .
Cecilia Gutierrez-Perez, Charles Puerner, Jane T Jones, Sandeep Vellanki, Elisa M Vesely, Timothy J Opperman

mBio· July 2024

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Exposure of Escherichia coli to antibiotic-efflux pump inhibitor combinations in a pharmacokinetic model: impact on bacterial clearance and drug resistance.
Alasdair P MacGowan, M L G Attwood, Alan R Noel, R Barber, Zachary Aron, Timothy J Opperman

J Antimicrob Chemother· December 2023

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Cell-Based Assay to Determine Type 3 Secretion System Translocon Assembly in Using Split Luciferase.
Hanling Guo, Emily J Geddes, Timothy J Opperman, Alejandro P Heuck

ACS Infect Dis· December 2023

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Luciferase-Based High-Throughput Screen with Aspergillus fumigatus to Identify Antifungal Small Molecules.
Timothy J Opperman, Sourabh Dhingra, Cecilia Gutierrez-Perez, Steven M Kwasny, Robert A Cramer

Methods Mol Biol· April 2023

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Investigating N-arylpyrimidinamine (NAPA) compounds as early-stage inhibitors against human cytomegalovirus.
Andrea J Parsons, Sabrina I Ophir, Thomas J Gardner, Jailene Casado Paredes, Kathryn R Stein, Timothy J Opperman

Antiviral Res· January 2023

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Adjunctive therapy for multidrug-resistant bacterial infections: Type III secretion system and efflux inhibitors.
Donald T Moir, Timothy J Opperman, Zachary D Aron, Terry L Bowlin

Drug Discov Today· September 2021

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trans-Translation inhibitors bind to a novel site on the ribosome and clear Neisseria gonorrhoeae in vivo.
Zachary D Aron, Atousa Mehrani, Eric D Hoffer, Kristie L Connolly, Pooja Srinivas, Timothy J Opperman

Nat Commun· March 2021

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Optimization of a Benzothiazole Indolene Scaffold Targeting Bacterial Cell Wall Assembly.
Jay Chauhan, Wenbo Yu, Steven Cardinale, Timothy J Opperman, Alexander D MacKerell

Drug Des Devel Ther· October 2020

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Optimization of a small-molecule Lipid II binder.
Jay Chauhan, Steven M Kwasny, Steven Fletcher, Timothy J Opperman, Erik P H de Leeuw

Bioorg Med Chem Lett· July 2019

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Pleiotropic Anti-Infective Effects of Defensin-Derived Antimicrobial Compounds.
Erik P H de Leeuw, Sung Hyen Lee, Woo H Kim, Steven M Kwasny, Timothy J Opperman

Avian Dis· December 2018

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The hydrophobic trap-the Achilles heel of RND efflux pumps.
Zachary Aron, Timothy J Opperman

Res Microbiol· November 2018

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Lack of AcrB Efflux Function Confers Loss of Virulence on Serovar Typhimurium.
Xuan Wang-Kan, Jessica M A Blair, Barbara Chirullo, Jonathan Betts, Roberto M La Ragione, Timothy J Opperman

mBio· July 2017

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Towards Development of Small Molecule Lipid II Inhibitors as Novel Antibiotics.
Jamal Chauhan, Steven Cardinale, Lei Fang, Jing Huang, Steven M Kwasny, Timothy J Opperman

PLoS One· June 2017

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DNA Targeting as a Likely Mechanism Underlying the Antibacterial Activity of Synthetic Bis-Indole Antibiotics.
Timothy J Opperman, Steven M Kwasny, Jessica Bo Li, Mark A Lewis, Daniel Aiello

Antimicrob Agents Chemother· December 2016

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Convallatoxin-Induced Reduction of Methionine Import Effectively Inhibits Human Cytomegalovirus Infection and Replication.
Tobias Cohen, John D Williams, Timothy J Opperman, Roberto Sanchez, Nell S Lurain

J Virol· December 2016

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Optimization of a novel series of pyranopyridine RND efflux pump inhibitors.
Zachary Aron, Timothy J Opperman

Curr Opin Microbiol· October 2016

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Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives.
Hanno Sjuts, Attilio V Vargiu, Steven M Kwasny, Son T Nguyen, Hong-Suk Kim, Timothy J Opperman

Proc Natl Acad Sci U S A· March 2016

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Structure-activity exploration of a small-molecule Lipid II inhibitor.
Steven Fletcher, Wenbo Yu, Jing Huang, Steven M Kwasny, Jay Chauhan, Timothy J Opperman

Drug Des Devel Ther· February 2016

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Discovery of bacterial fatty acid synthase type II inhibitors using a novel cellular bioluminescent reporter assay.
Joselynn Wallace, Nicholas O Bowlin, Debra M Mills, Panatda Saenkham, Steven M Kwasny, Timothy J Opperman

Antimicrob Agents Chemother· September 2015

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Synthesis and antifungal evaluation of head-to-head and head-to-tail bisamidine compounds.
Son T Nguyen, Steven M Kwasny, Xiaoyuan Ding, John D Williams, Norton P Peet, Timothy J Opperman

Bioorg Med Chem· September 2015

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TAOK3 phosphorylates the methylenecyclopropane nucleoside MBX 2168 to its monophosphate.
Gloria Komazin-Meredith, Steven C Cardinale, Katelyn Comeau, Kevin J Magalhaes, Caroll B Hartline, Timothy J Opperman

Antiviral Res· July 2015

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Structure-activity relationships of a novel pyranopyridine series of Gram-negative bacterial efflux pump inhibitors.
Son T Nguyen, Steven M Kwasny, Xiaoyuan Ding, Steven C Cardinale, Courtney T McCarthy, Timothy J Opperman

Bioorg Med Chem· May 2015

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Recent advances toward a molecular mechanism of efflux pump inhibition.
Timothy J Opperman, Son T Nguyen

Front Microbiol· May 2015

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Molecular mechanism of MBX2319 inhibition of Escherichia coli AcrB multidrug efflux pump and comparison with other inhibitors.
Attilio V Vargiu, Paolo Ruggerone, Timothy J Opperman, Son T Nguyen, Hiroshi Nikaido

Antimicrob Agents Chemother· October 2014

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