Publications by authors named "Timothy Pabst"

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Formation of transient highly-charged mAb clusters strengthens interactions with host cell proteins and results in poor clearance of host cell proteins by protein A chromatography.
Haibin Luo, Qun Du, Chen Qian, Michelle Mlynarczyk, Timothy M Pabst

J Chromatogr A· August 2022

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Role of configurational flexibility on the adsorption kinetics of bivalent bispecific antibodies on porous cation exchange resins.
Lucas K Kimerer, Timothy M Pabst, Alan K Hunter, Giorgio Carta

J Chromatogr A· October 2021

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Chromatographic and adsorptive behavior of a bivalent bispecific antibody and associated fragments.
Lucas K Kimerer, Ben Niu, Timothy M Pabst, Weiguo Zhai, Alan K Hunter

J Chromatogr A· July 2021

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Safety risk management for low molecular weight process-related impurities in monoclonal antibody therapeutics: Categorization, risk assessment, testing strategy, and process development with leveraging clearance potential.
Haibin Luo, Yuling Li, David Robbins, Sheau-Chiann Wang, Guoling Xi, Timothy M Pabst

Biotechnol Prog· May 2021

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Chromatographic behavior of bivalent bispecific antibodies on hydrophobic interaction chromatography columns.
Lucas K Kimerer, Timothy M Pabst, Alan K Hunter, Giorgio Carta

J Chromatogr A· April 2020

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Process optimization and protein engineering mitigated manufacturing challenges of a monoclonal antibody with liquid-liquid phase separation issue by disrupting inter-molecule electrostatic interactions.
Qun Du, Melissa Damschroder, Timothy M Pabst, Alan K Hunter, William K Wang

MAbs· January 2020

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Chromatographic behavior of bivalent bispecific antibodies on cation exchange columns. II. Biomolecular perspectives.
Lucas K Kimerer, Timothy M Pabst, Alan K Hunter, Giorgio Carta

J Chromatogr A· September 2019

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Chromatographic behavior of bivalent bispecific antibodies on cation exchange columns. I. Experimental observations and phenomenological model.
Lucas K Kimerer, Timothy M Pabst, Alan K Hunter, Giorgio Carta

J Chromatogr A· September 2019

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Systematic Interpolation Method Predicts Antibody Monomer-Dimer Separation by Gradient Elution Chromatography at High Protein Loads.
Arch Creasy, Jason Reck, Timothy Pabst, Alan Hunter, Gregory Barker

Biotechnol J· March 2019

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Cathepsin L Causes Proteolytic Cleavage of Chinese-Hamster-Ovary Cell Expressed Proteins During Processing and Storage: Identification, Characterization, and Mitigation.
Haibin Luo, Liu Tie, Mingyan Cao, Alan K Hunter, Timothy M Pabst

Biotechnol Prog· January 2019

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Evaluation of recent Protein A stationary phase innovations for capture of biotherapeutics.
Timothy M Pabst, Johnny Thai, Alan K Hunter

J Chromatogr A· June 2018

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Separation of antibody monomer-dimer mixtures by frontal analysis.
Jason M Reck, Timothy M Pabst, Alan K Hunter, Giorgio Carta

J Chromatogr A· June 2017

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Liquid-liquid phase separation causes high turbidity and pressure during low pH elution process in Protein A chromatography.
Haibin Luo, Nacole Lee, Xiangyang Wang, Yuling Li, Albert Schmelzer, Timothy Pabst

J Chromatogr A· March 2017

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Camelid V H affinity ligands enable separation of closely related biopharmaceuticals.
Timothy M Pabst, Michaela Wendeler, Xiangyang Wang, Sandra Bezemer, Pim Hermans

Biotechnol J· February 2017

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Development and scale-up of a commercial fed batch refolding process for an anti-CD22 two chain immunotoxin.
Thomas Linke, Matthew T Aspelund, Christopher Thompson, Guoling Xi, Andrew Fulton, Timothy M Pabst

Biotechnol Prog· August 2015

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Adsorption equilibrium and kinetics of monomer-dimer monoclonal antibody mixtures on a cation exchange resin.
Jason M Reck, Timothy M Pabst, Alan K Hunter, Xiangyang Wang, Giorgio Carta

J Chromatogr A· July 2015

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Engineering of novel Staphylococcal Protein A ligands to enable milder elution pH and high dynamic binding capacity.
Timothy M Pabst, Ronnie Palmgren, Annika Forss, Jelena Vasic, Mariko Fonseca

J Chromatogr A· October 2014

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Process-scale purification and analytical characterization of highly gamma-carboxylated recombinant human prothrombin.
Michaela Wendeler, Timothy M Pabst, Jihong Wang, Robert J Strouse, Xiangyang Wang

J Chromatogr A· January 2014

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Binding and elution behavior of proteins on strong cation exchangers.
Timothy M Pabst, Eric J Suda, Kristin E Thomas, Paul Mensah, Natraj Ramasubramanyan

J Chromatogr A· November 2009

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Comparison of agarose and dextran-grafted agarose strong ion exchangers for the separation of protein aggregates.
Eric J Suda, Kristin E Thomas, Timothy M Pabst, Paul Mensah, Natraj Ramasubramanyan

J Chromatogr A· July 2009

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Separation of protein charge variants with induced pH gradients using anion exchange chromatographic columns.
Timothy M Pabst, Giorgio Carta, Natrajan Ramasubramanyan, Alan K Hunter, Paul Mensah

Biotechnol Prog· April 2009

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Protein separations with induced pH gradients using cation-exchange chromatographic columns containing weak acid groups.
Timothy M Pabst, Dorota Antos, Giorgio Carta, Natarajan Ramasubramanyan, Alan K Hunter

J Chromatogr A· February 2008

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Comparison of strong anion-exchangers for the purification of a PEGylated protein.
Timothy M Pabst, John J Buckley, Natraj Ramasubramanyan, Alan K Hunter

J Chromatogr A· April 2007

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pH transitions in cation exchange chromatographic columns containing weak acid groups.
Timothy M Pabst, Giorgio Carta

J Chromatogr A· February 2007

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