Publications by authors named "Timothy Sheahan"

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Novel tricycle expanded purine nucleosides with pan-viral activity.
Céline Martin-Ghoteimi, Kyle A Davis, Rayane Ghoteimi, Meareg Amare, Meghan V Diefenbacher, Timothy P Sheahan

Bioorg Med Chem· December 2025

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Mouse-adapted SARS-CoV-2 Omicron BA.5 infection induces post-acute lung fibrosis in BALB/c mice.
John M Powers, Sarah R Leist, Naveenchandra Suryadevara, Seth J Zost, Elad Binshtein, Timothy P Sheahan

J Virol· November 2025

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Exploration of 4'-fluoro fleximer nucleoside analogues as potential broad-spectrum antiviral agents.
Kyle A Davis, Jason K Smith, Jessica L Smith, Meareg Amare, Meghan V Diefenbacher, Timothy P Sheahan

Bioorg Med Chem· October 2025

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Human Coronavirus HKU1 Neutralizing Monoclonal Antibodies Target Diverse Epitopes Within and Around the TMPRSS2 Receptor Binding Site.
Lingshu Wang, Jeswin Joseph, Sheena Vasquez, Daniel Wrapp, Timothy P Sheahan

bioRxiv· October 2025

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Meeting report: 38th international conference on antiviral research in Las Vegas, United States of America, March 17-21, 2025.
Robert Jordan, Nancie M Archin, Valeria Cagno, Joy Y Feng, Haitao Guo, Timothy P Sheahan

Antiviral Res· September 2025

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Research protocol design and implementation of a hybrid no-touch and low-touch prospective observational study during the COVID-19 public health emergency: the VISION study.
Becky Straub, Katie R Mollan, Jessica R Keys, Chanhwa Lee, Ronald Swanstrom, Timothy P Sheahan

BMJ Public Health· September 2025

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Disparate SARS-CoV-2 Infection Outcomes Abound, but What Makes SARS-CoV-2 Bound for Rebound?
Timothy P Sheahan

J Infect Dis· July 2025

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Mouse Adapted Omicron BA.5 Induces A Fibrotic Lung Disease Phenotype in BALB/c Mice.
John M Powers, Sarah R Leist, Naveenchandra Suryadevara, Seth J Zost, Elad Binshtein, Timothy P Sheahan

bioRxiv· July 2025

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Varying Malaria Rapid Diagnostic Test Accuracy by Regional Transmission Level and Demographics in Tanzania.
Danielle Wiener, Misago D Seth, Celine I Mandara, Rashid A Madebe, Zachary R Popkin-Hall, Timothy P Sheahan

medRxiv· July 2025

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Mechanism and spectrum of inhibition of viral polymerases by 2'-deoxy-2'-β-fluoro-4'-azidocytidine or azvudine.
Hery W Lee, Egor P Tchesnokov, Laura J Stevens, Tia M Hughes, Meghan V Diefenbacher, Timothy P Sheahan

NAR Mol Med· July 2025

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A neutralizing human antibody induces movement of the HCoV-229E receptor binding domain.
Mera F Liccione, Trevor Scobey, Heather M Froggatt, Camryn Pajon, Boyd L Yount, Timothy P Sheahan

bioRxiv· May 2025

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Dysregulation of lung epithelial cell homeostasis and immunity contributes to Middle East respiratory syndrome coronavirus disease severity.
Amy C Sims, Alexandra Schäfer, Kenichi Okuda, Sarah R Leist, Jacob F Kocher, Timothy P Sheahan

mSphere· February 2025

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Meeting report of the 37th International Conference on Antiviral Research in Gold Coast, Australia, May 20-24, 2024, organized by the International Society for Antiviral Research.
Stephen R Welch, John P Bilello, Kara Carter, Leen Delang, Larissa Dirr, Timothy P Sheahan

Antiviral Res· December 2024

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An oral non-covalent non-peptidic inhibitor of SARS-CoV-2 Mpro ameliorates viral replication and pathogenesis in vivo.
Nian E Zhou, Su Tang, Xuelin Bian, Maloy K Parai, Inna V Krieger, Timothy P Sheahan

Cell Rep· November 2024

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The oral nucleoside prodrug GS-5245 is efficacious against SARS-CoV-2 and other endemic, epidemic, and enzootic coronaviruses.
David R Martinez, Fernando R Moreira, Nicholas J Catanzaro, Meghan V Diefenbacher, Mark R Zweigart, Timothy P Sheahan

Sci Transl Med· May 2024

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A compendium of multi-omics data illuminating host responses to lethal human virus infections.
Amie J Eisfeld, Lindsey N Anderson, Shufang Fan, Kevin B Walters, Peter J Halfmann, Timothy P Sheahan

Sci Data· April 2024

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Divergent pathogenetic outcomes in BALB/c mice following Omicron subvariant infection.
John M Powers, Sarah R Leist, Michael L Mallory, Boyd L Yount, Kendra L Gully, Timothy P Sheahan

Virus Res· March 2024

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Host genetic variation guides hepacivirus clearance, chronicity, and liver fibrosis in mice.
Ariane J Brown, John J Won, Raphael Wolfisberg, Ulrik Fahnøe, Nicholas Catanzaro, Timothy P Sheahan

Hepatology· January 2024

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A nano-luciferase expressing human coronavirus OC43 for countermeasure development.
Meghan V Diefenbacher, Thomas J Baric, David R Martinez, Ralph S Baric, Nicholas J Catanzaro, Timothy P Sheahan

Virus Res· January 2024

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Hepatoviruses promote very-long-chain fatty acid and sphingolipid synthesis for viral RNA replication and quasi-enveloped virus release.
Tomoyuki Shiota, Zhucui Li, Guan-Yuan Chen, Kevin L McKnight, Takayoshi Shirasaki, Timothy P Sheahan

Sci Adv· October 2023

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Advancement in Cellular Topographic and Nanoparticle Capture Imaging by High Resolution Microscopy Incorporating a Freeze-Drying and Gaseous Nitrogen-based Approach.
Kunihiro Uryu, Nadine Soplop, Timothy P Sheahan, Maria-Teresa Catanese, Chuong Huynh

bioRxiv· September 2023

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Efficacy of the oral nucleoside prodrug GS-5245 (Obeldesivir) against SARS-CoV-2 and coronaviruses with pandemic potential.
David R Martinez, Fernando R Moreira, Mark R Zweigart, Kendra L Gully, Gabriela De la Cruz, Timothy P Sheahan

bioRxiv· June 2023

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Vaccines and therapeutics for immunocompromised patients with COVID-19.
Shmuel Shoham, Carolina Batista, Yanis Ben Amor, Onder Ergonul, Mazen Hassanain, Timothy Sheahan

EClinicalMedicine· May 2023

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Respiratory viruses: New frontiers-a Keystone Symposia report.
Jennifer Cable, Jie Sun, In Su Cheon, Andrew E Vaughan, Italo A Castro, Timothy P Sheahan

Ann N Y Acad Sci· April 2023

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Programmable antivirals targeting critical conserved viral RNA secondary structures from influenza A virus and SARS-CoV-2.
Rachel J Hagey, Menashe Elazar, Edward A Pham, Siqi Tian, Lily Ben-Avi, Timothy P Sheahan

Nat Med· September 2022

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