Publications by authors named "Timothy W Robison"

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Assessing carcinogenic outcomes following short-term exposure to potentially DNA-reactive drugs: Are available data sufficient to inform risk assessment?
Dayton M Petibone, Jennifer M Shemansky, Timothy W Robison, Aisar H Atrakchi, Robert H Heflich

Regul Toxicol Pharmacol· November 2025

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Germline mutagenicity of molnupiravir and its active form, β-d-N4-hydroxycytidine, in Caenorhabditis elegans evaluated using whole-genome sequencing.
Li Xia, Jian Yan, Ying Chen, Timothy W Robison, Tao Chen

Toxicol Lett· June 2025

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Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations.
Yiying Wang, Yuan Le, Kelly L Harris, Ying Chen, Xilin Li, Timothy W Robison

Mutat Res Genet Toxicol Environ Mutagen· July 2024

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Erythrocyte PIG-A mutant frequencies in cancer patients receiving cisplatin.
Vasily N Dobrovolsky, Omar T Atiq, Robert H Heflich, Mackean Maisha, Page B McKinzie, Timothy W Robison

Cancer Med· February 2024

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Evaluation of mutagenic susceptibility of different stages in germ cell development of Caenorhabditis elegans using whole genome sequencing.
Hua Du, Bohu Pan, Alexander W Alund, Jian Yan, Ying Chen, Timothy W Robison

Arch Toxicol· August 2023

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Appropriate in vivo follow-up assays to an in vitro bacterial reverse mutation (Ames) test positive investigational drug candidate (active pharmaceutical ingredient), drug-related metabolite, or drug-related impurity.
Timothy W Robison, Robert H Heflich, Mugimane G Manjanatha, Rosalie Elespuru, Aisar Atrakchi

Mutat Res Genet Toxicol Environ Mutagen· September 2021

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Mutational signatures in T-lymphocytes of rats treated with N-propyl-N-nitrosourea and procarbazine.
Javier R Revollo, Page B McKinzie, Timothy W Robison, Vasily N Dobrovolsky

Environ Mol Mutagen· July 2021

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Genetic toxicity testing using human in vitro organotypic airway cultures: Assessing DNA damage with the CometChip and mutagenesis by Duplex Sequencing.
Yiying Wang, Roberta A Mittelstaedt, Rebecca Wynne, Ying Chen, Xuefei Cao, Timothy W Robison

Environ Mol Mutagen· June 2021

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Mutagenicity of silver nanoparticles evaluated using whole-genome sequencing in mouse lymphoma cells.
Bohu Pan, Pravin R Kaldhone, Alexander W Alund, Hua Du, Xiaoqing Guo, Timothy W Robison

Nanotoxicology· April 2021

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Performance of HepaRG and HepG2 cells in the high-throughput micronucleus assay for in vitro genotoxicity assessment.
Xiaoqing Guo, Ji-Eun Seo, Dayton Petibone, Volodymyr Tryndyak, Un Jung Lee, Timothy W Robison

J Toxicol Environ Health A· November 2020

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CD59-deficient bone marrow erythroid cells from rats treated with procarbazine and propyl-nitrosourea have mutations in the Pig-a gene.
Javier R Revollo, Azra Dad, Mason G Pearce, Roberta A Mittelstaedt, Andrea Casildo, Timothy W Robison

Environ Mol Mutagen· October 2020

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Performance of high-throughput CometChip assay using primary human hepatocytes: a comparison of DNA damage responses with in vitro human hepatoma cell lines.
Ji-Eun Seo, Qiangen Wu, Matthew Bryant, Lijun Ren, Qiang Shi, Timothy W Robison

Arch Toxicol· June 2020

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Pig-a mutations in bone marrow erythroblasts of rats treated with 7,12-dimethyl-benz[a]anthracene.
Javier R Revollo, Azra Dad, Mason G Pearce, Roberta A Mittelstaedt, Timothy W Robison

Mutat Res Genet Toxicol Environ Mutagen· December 2019

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Quantitative comparison of in vitro genotoxicity between metabolically competent HepaRG cells and HepG2 cells using the high-throughput high-content CometChip assay.
Ji-Eun Seo, Volodymyr Tryndyak, Qiangen Wu, Kostiantyn Dreval, Igor Pogribny, Timothy W Robison

Arch Toxicol· May 2019

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Analysis of mutation in the rat Pig-a assay: I) studies with bone marrow erythroid cells.
Javier R Revollo, Mason G Pearce, Azra Dad, Dayton M Petibone, Timothy W Robison

Environ Mol Mutagen· October 2018

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Monitoring humans for somatic mutation in the endogenous PIG-a gene using red blood cells.
Vasily N Dobrovolsky, Rosalie K Elespuru, C Anita H Bigger, Timothy W Robison, Robert H Heflich

Environ Mol Mutagen· December 2011

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Voluntary exploratory data submissions to the US FDA and the EMA: experience and impact.
Federico M Goodsaid, Shashi Amur, Jiri Aubrecht, Michael E Burczynski, Kevin Carl, Timothy W Robison

Nat Rev Drug Discov· June 2010

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Metabolites in safety testing.
Timothy W Robison, Abigail Jacobs

Bioanalysis· October 2009

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Current and future application of genetic toxicity assays: the role and value of in vitro mammalian assays.
Rosalie K Elespuru, Rajiv Agarwal, Aisar H Atrakchi, C Anita H Bigger, Robert H Heflich, Timothy W Robison

Toxicol Sci· June 2009

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