Publications by authors named "Ting-Jen Cheng"

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Streamlined Synthesis and Immunomodulatory Effects of Ulvan Oligosaccharides from Marine Green Algae.
Junpei Shimabukuro, Ci-Hua Shen, Tsung-Kai Hsueh, Ting-Wen Chen, Yin-Chen Tseng, Cheng-Hsiu Chang, Ting-Jen Rachel Cheng, Shang-Cheng Hung

J Am Chem Soc· September 2025

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Identification of PTGR2 inhibitors as a new therapeutic strategy for diabetes and obesity.
Yi-Cheng Chang, Meng-Lun Hsieh, Hsiao-Lin Lee, Siow-Wey Hee, Chi-Fon Chang, Ting-Jen Rachel Cheng

EMBO Mol Med· May 2025

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Author Correction: Identification of PTGR2 inhibitors as a new therapeutic strategy for diabetes and obesity.
Yi-Cheng Chang, Meng-Lun Hsieh, Hsiao-Lin Lee, Siow-Wey Hee, Chi-Fon Chang, Ting-Jen Rachel Cheng

EMBO Mol Med· May 2025

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Structure-Based Mechanism and Specificity of Human Galactosyltransferase β3GalT5.
Jennifer M Lo, Chih-Chuan Kung, Ting-Jen Rachel Cheng, Chi-Huey Wong, Che Ma

J Am Chem Soc· April 2025

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Synthesis of a dendritic cell-targeted self-assembled polymeric nanoparticle for selective delivery of mRNA vaccines to elicit enhanced immune responses.
Chen-Yo Fan, Szu-Wen Wang, Cinya Chung, Jia-Yan Chen, Chia-Yen Chang, Ting-Jen R Cheng

Chem Sci· July 2024

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Dual-targeting compounds possessing enhanced anticancer activity via microtubule disruption and histone deacetylase inhibition.
Yu-Wei Tseng, Tsung-Jung Yang, Yuan-Ling Hsu, Jyung-Hurng Liu, Yin-Chen Tseng, Ting-Jen Rachel Cheng

Eur J Med Chem· February 2024

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Degradation of neurodegenerative disease-associated TDP-43 aggregates and oligomers via a proteolysis-targeting chimera.
Yu-Ling Tseng, Po-Chao Lu, Chi-Chang Lee, Ruei-Yu He, Yung-An Huang, Ting-Jen Rachel Cheng

J Biomed Sci· April 2023

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Structural compositions and biological activities of cell wall polysaccharides in the rhizome, stem, and leaf of Polygonatum odoratum (Mill.) Druce.
Jing Li, Shih-Yi Hsiung, Mu-Rong Kao, Xiaohui Xing, Shu-Chieh Chang, Ting-Jen Rachel Cheng

Carbohydr Res· November 2022

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Photoaffinity labeling of benzophenone-containing salicylanilide compounds to give an insight into the mechanism in disrupting peptidoglycan formation.
Hao-Chun Chuang, Ming-Fang Liu, Hsin-Yi Wu, Ying-Ta Wu, Ting-Jen Rachel Cheng

Bioorg Med Chem· August 2022

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Design and Synthesis of 1-- and 6'--Modified Heparan Sulfate Trisaccharides as Human Endo-6--Sulfatase 1 Inhibitors.
Kuei-Yao Tseng, Zheng-Hao Tzeng, Ting-Jen Rachel Cheng, Pi-Hui Liang, Shang-Cheng Hung

Front Chem· July 2022

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Harnessing natural-product-inspired combinatorial chemistry and computation-guided synthesis to develop -glycan modulators as anticancer agents.
Wei-An Chen, Yu-Hsin Chen, Chiao-Yun Hsieh, Pi-Fang Hung, Chiao-Wen Chen, Ting-Jen R Cheng, Wei-Chieh Cheng

Chem Sci· June 2022

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Vaccination with SARS-CoV-2 spike protein lacking glycan shields elicits enhanced protective responses in animal models.
Han-Yi Huang, Hsin-Yu Liao, Xiaorui Chen, Szu-Wen Wang, Cheng-Wei Cheng, Ting-Jen Rachel Cheng

Sci Transl Med· April 2022

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Immunogenicity Evaluation of N-Glycans Recognized by HIV Broadly Neutralizing Antibodies.
Sachin S Shivatare, Ting-Jen Rachel Cheng, Yang-Yu Cheng, Vidya S Shivatare, Tsung-I Tsai

ACS Chem Biol· October 2021

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A non-neutralizing antibody broadly protects against influenza virus infection by engaging effector cells.
Yi-An Ko, Yueh-Hsiang Yu, Yen-Fei Wu, Yung-Chieh Tseng, Chia-Lin Chen, Ting-Jen Rachel Cheng

PLoS Pathog· August 2021

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Nanoparticle composite TPNT1 is effective against SARS-CoV-2 and influenza viruses.
Sui-Yuan Chang, Kuo-Yen Huang, Tai-Ling Chao, Han-Chieh Kao, Yu-Hao Pang, Ting-Jen Rachel Cheng

Sci Rep· April 2021

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Identification of existing pharmaceuticals and herbal medicines as inhibitors of SARS-CoV-2 infection.
Jia-Tsrong Jan, Ting-Jen Rachel Cheng, Yu-Pu Juang, Hsiu-Hua Ma, Ying-Ta Wu, Cheng-Wei Cheng, Wei-Chieh Cheng, Shang-Cheng Hung

Proc Natl Acad Sci U S A· February 2021

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Chimeric hemagglutinin vaccine elicits broadly protective CD4 and CD8 T cell responses against multiple influenza strains and subtypes.
Hsin-Yu Liao, Shih-Chi Wang, Yi-An Ko, Kuo-I Lin, Che Ma, Ting-Jen Rachel Cheng

Proc Natl Acad Sci U S A· July 2020

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Trisaccharide Sulfate and Its Sulfonamide as an Effective Substrate and Inhibitor of Human Endo--sulfatase-1.
Li-Ting Chiu, Narayana Murthy Sabbavarapu, Wei-Chen Lin, Chiao-Yuan Fan, Chih-Chung Wu, Ting-Jen Rachel Cheng, Shang-Cheng Hung

J Am Chem Soc· March 2020

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Suppression of Drug-Resistant Non-Small-Cell Lung Cancer with Inhibitors Targeting Minichromosomal Maintenance Protein.
Chia-Yi Lin, Hsin-Yi Wu, Yuan-Ling Hsu, Ting-Jen Rachel Cheng, Jyung-Hurng Liu

J Med Chem· March 2020

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Genomic Analysis of Mycobacterium tuberculosis Isolates and Construction of a Beijing Lineage Reference Genome.
Woei-Fuh Wang, Mei-Yeh Jade Lu, Ting-Jen Rachel Cheng, Yi-Ching Tang, Yu-Chuan Teng

Genome Biol Evol· February 2020

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Disrupting the Conserved Salt Bridge in the Trimerization of Influenza A Nucleoprotein.
Jennifer L Woodring, Shao-Hung Lu, Larissa Krasnova, Shih-Chi Wang, Jhih-Bin Chen, Ting-Jen Rachel Cheng

J Med Chem· January 2020

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Antibody blockade of Dectin-2 suppresses house dust mite-induced Th2 cytokine production in dendritic cell- and monocyte-depleted peripheral blood mononuclear cell co-cultures from asthma patients.
Ming-Han Chen, Ming-Ting Huang, Wen-Kuang Yu, Shinn-Shing Lee, Jia-Horng Wang, Ting-Jen R Cheng

J Biomed Sci· December 2019

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Structure-guided development of purine amide, hydroxamate, and amidoxime for the inhibition of non-small cell lung cancer.
Meng-Ruo Huang, Yuan-Ling Hsu, Tzu-Chen Lin, Ting-Jen Cheng, Ling-Wei Li

Eur J Med Chem· November 2019

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4(1H)-quinolone derivatives overcome acquired resistance to anti-microtubule agents by targeting the colchicine site of β-tubulin.
Ming-Shiu Lin, Tse-Ming Hong, Ting-Hung Chou, Shuenn-Chen Yang, Wei-Chia Chung, Ting-Jen Rachel Cheng

Eur J Med Chem· November 2019

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Structural analysis and biological activity of cell wall polysaccharides extracted from Panax ginseng marc.
Jing Li, Damao Wang, Xiaohui Xing, Ting-Jen Rachel Cheng, Pi-Hui Liang

Int J Biol Macromol· August 2019

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